Occupational and Genetic Risk Factors Associated With Intervertebral Disc Disease

Virtanen, Iita M; Karppinen, Jaro; Taimela, Simo; Ott, Jürg; Barral, Sandra; Kaikkonen, Kaisu; Heikkilä, Olli; Mutanen, Pertti; Noponen, Noora; Männikkö, Minna; Tervonen, Osmo; Natri, Antero; Ala‐Kokko, Leena

doi:10.1097/01.brs.0000261473.03274.5c

Cited by 89 publications

(52 citation statements)

References 38 publications

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“…The prevalence rate of back-leg pain from disc degeneration was as high as 60% to 80% (Diwan et al, 2000). The studies on the cause of disc degeneration found that mechanical factors (Hansson and Holm, 1991), gene profiling (Annunen et al, 1999;Ala-Kokko, 2002;Virtanen et al, 2007), and smoking (Kaila-Kangas et al, 2003) were considered; especially, aging was a close correlation (Miller et al, 1988;Boos et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Features of intervertebral disc degeneration in rat’s aging process

Zhang

Sun

Liu

et al. 2009

J. Zhejiang Univ. Sci. B

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Abstract:Objective: The age-related change is important part of degenerative disc disease. However, no appropriate animal model or objective evaluation index is available. This study aimed to investigate the features of intervertebral disc degeneration in aging process of rats. Methods: 22-month-old Sprague-Dawley (SD) rats were used as spontaneously occurring intervertebral disc degeneration models and 6-month-old rats as young controls. Expression of collagen types II and X was measured by immunohistochemistry. Degenerations of intervertebral discs were scored according to Miyamoto's method. Numbers and areas of afferent vascular buds were measured. The thicknesses of non-calcified and calcified layers were measured and statistically analyzed. Results: There were less collagen type II expression and more collagen type X expression in the calcified layer of the cartilage endplates and nucleus pulposus in the rats of the aged group than in the young control. There were fewer and smaller afferent vascular buds in the rats of the aged group than in the young control group. The ratio of the non-calcified to the calcified layers in the rats of the aged group significantly decreased, compared with that of the young control group (P<0.01). Conclusion: Rats can spontaneously establish intervertebral disc age-related degeneration. The expression of collagen types II and X, numbers and areas of afferent vascular buds, the ratio of the non-calcified to the calcified layers, and water and glycosaminoglycan contents in the nucleus pulposus are sensitive indexes of intervertebral disc degeneration.

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Section: Introductionmentioning

confidence: 99%

Features of intervertebral disc degeneration in rat’s aging process

Zhang

Sun

Liu

et al. 2009

J. Zhejiang Univ. Sci. B

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“…The aetiology of this disorder is unknown but may be due to the relative avascularity of the tissue, mineralization of or trauma to the cartilage endplate, mechanical factors, vertebral body microfracture and loss of notochordal cells. Whatever the exact pathway, disc degeneration is certainly associated with aging and has a strong genetic component [1,10,96,109,115,120]. The back pain that can develop either in association with or as a result of this disease has a lifetime prevalence of 80%.…”

Section: Introductionmentioning

confidence: 99%

Tissue engineering and the intervertebral disc: the challenges

2008

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Disc degeneration is a common disorder. Although the back pain that can develop in association with this is rarely life-threatening, the annual cost in terms of morbidity, lost productivity, medical expenses and workers' compensation benefits is significant. Surgical intervention as practised currently is directed towards removing the damaged or altered tissue. Development of new treatment modalities is critical as there is a growing consensus that the strategies used currently for symptomatic degenerative disc disease may not be effective. Accordingly, there is a need to develop an entirely new way to treat this disorder; regenerative medicine and tissue engineering approaches appear particularly promising in this regard. This paper reviews some of the challenges that currently are limiting the clinical application of this approach to the treatment of disc degeneration.

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“…To date, several studies have tested the association between the COL9A2 gene and development of intervertebral disc disease in various populations (Annunen et al, 1999;Kales et al, 2004;Virtanen et al, 2007;Rathod et al, 2012;Janeczko et al, 2014). Annunen et al (1999) carried out an investigation involving 157 patients and 174 controls, identifying a COL9A2 genetic mutation that cosegregates with the disease phenotype.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study incorporating 86 monozygotic and binovular twins, the heritability of this condition was found to be 74% (Sambrook et al, 1999). To date, many investigations have indicated that vitamin D receptor, matrix metalloproteinases, and interleukins contribute to the development of intervertebral disc disease (Noponen-Hietala et al, 2005;Virtanen et al, 2007;Karli et al, 2014;Aras et al, 2016;Shi et al, 2016). However, its molecular pathogenesis is not fully understood, and the identification of novel drug targets is essential.…”

Section: Introductionmentioning

confidence: 99%

Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population

et al. 2016

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ABSTRACT.Intervertebral disc disease is a multifactorial condition, yet disease pathogenesis that can be promoted by a single dominant mutation affecting the expression of susceptibility genes. We performed a case-control study to assess the influence of the COL9A2 Gln326Arg polymorphism on risk of intervertebral disc disease in a Chinese population. Between March 2014 and March 2015, a total of 215 patients and 230 healthy controls were recruited from Binzhou Medical University Hospital. Genotyping of COL9A2 Gln326Arg was carried out using polymerase chain reaction-restriction fragment length polymorphism. Univariate and multivariate logistic regression analyses revealed that the Arg/Arg genotype of COL9A2 Gln326Arg was associated with increased risk of intervertebral disc disease in comparison to the Gln/Gln genotype [crude odds ratio (OR) = 2.25, 2 T. Meng et al. Genetics and Molecular Research 15 (4): gmr1504895895% confidence interval (CI) = 1.12-4.62; adjusted OR = 2.46, 95%CI = 1.20-5.29]. Moreover, the Arg/Arg genotype correlated with an elevated risk of this disease compared to the Gln/Gln + Gln/ Arg genotypes (crude OR = 2.21, 95%CI = 1.17-4.30; adjusted OR = 2.42, 95%CI = 1.28-5.51). In conclusion, our results suggest that the COL9A2 Gln326Arg polymorphism contributes to the development of intervertebral disc disease in the Chinese population.

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Occupational and Genetic Risk Factors Associated With Intervertebral Disc Disease

Cited by 89 publications

References 38 publications

Features of intervertebral disc degeneration in rat’s aging process

Features of intervertebral disc degeneration in rat’s aging process

Tissue engineering and the intervertebral disc: the challenges

Association between COL9A2 Gln326Arg mutations and the development of intervertebral disc disease in a Chinese population

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