Occupational Asbestos Exposure and Lung Cancer—A Systematic Review of the Literature

Nielsen, Lene Kongsgaard; Bælum, Jesper; Rasmussen, Jesper; Dahl, S; Olsen, Karen Ege; Albin, María; Hansen, Nina Beck; Sherson, David

doi:10.1080/19338244.2013.863752

Cited by 105 publications

(82 citation statements)

References 92 publications

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“…In 1997, the Helsinski criteria for identifying individuals with a high risk of asbestos exposure at work were accepted (2). Older studies found inconsistent results regarding the lobe of origin and histology of asbestos-related lung cancer (ARLC) (3). Some studies showed an upper lobe location similar to tobacco-related lung cancer, whereas other investigators found a lower lobe location (4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Asbestos-related lung cancers: A retrospective clinical and pathological study

Uguen

Dewitte

Marcorelles

et al. 2017

Molecular and Clinical Oncology

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Abstract. Exposure to asbestos results in serious risks of developing mesothelioma and lung cancer. The link between asbestos exposure and lung carcinoma is well established. Nevertheless, precise histopathological data are poorly considered when investigating the asbestos-cancer link in a compensatory approach. In the present study, we aim to describe the features of individuals with compensated lung cancer who were referred to an occupational disease center, regarding occupational exposure to asbestos, smoking history and pathological data. We led a retrospective study of compensated ARLC cases seen in our occupational disease center between 2003 and 2013. A total of 146 men were included (mean age at diagnosis, 63.2 years) of whom approximately 90% were heavy current or former smokers (mean value, 30.4 packs/year). The major industries associated with the lung cancer cases were shipbuilding (69.9%), and building construction (7.5%) in this harbor region. The results of the present study showed that lung upper lobe was most prevalent (61.6%) and an excess of adenocarcinoma was found (45.9%), followed by squamous cell carcinoma (38.4%) as well as thoracic sarcomas (2.1%). Neoplasm was not histologically proven in 6.8% of the cases. Subsequent pathology examinations also reclassified 2 tumors as metastases from esophageal and laryngeal origins. In conclusion, smoking prevention should be encouraged in asbestos-exposed workers as reflected by the number of smokers with asbestos-related lung cancer. Thus, histological data should be considered further to evaluate the potent relationship between asbestos exposure and lung malignancy, especially in a compensatory approach.

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Section: Introductionmentioning

confidence: 99%

Asbestos-related lung cancers: A retrospective clinical and pathological study

Uguen

Dewitte

Marcorelles

et al. 2017

Molecular and Clinical Oncology

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“…Pleural plaques are widely referred to (Attanoos & Gibbs, 2009;Dalphin, 2011;Dweik & Mazzone, 2010;Edelman, 1988;Gevenois & De Vuyst, 2006;Fishwick & Barber, 2014;Hourihane et al, 1966;IIAC, 2008;Moolgavkar et al, 2014;Nielsen et al, 2014) as ''markers of asbestos exposure 9 '' or an index or ''signpost'' (Sargent et al, 1977) of exposure meaning that (other things being equal) an asbestos-exposed person that develops a pleural plaque is likely to have had greater asbestos exposure than someone without a plaque. 10 Thus, even if the development of pleural plaques is an entirely independent process from the development of malignant effects, such as lung cancer or mesothelioma, it is likely that there will be a correlation between pleural plaques and other serious endpoints, including lung cancer or mesothelioma.…”

Section: Pleural Plaques As Markers Of Exposurementioning

confidence: 99%

Are pleural plaques an appropriate endpoint for risk analyses?

Maxim¹,

Niebo²,

Utell

2015

Inhalation Toxicology

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This review summarizes the literature on the relation between the development of pleural plaques and non-malignant and malignant disease in cohorts exposed to asbestos and other fibers. The available evidence indicates that, absent any other pleural disease, the presence of pleural plaques does not result in respiratory symptoms or clinically significant impacts on lung function. For certain types of asbestos, the development of pleural plaques is statistically correlated with malignant disease, but the evidence is consistent with the hypothesis that pleural plaques without other pleural disease are a marker of exposure, rather than an independent risk factor. Pleural plaques have also developed in cohorts exposed to other fibers that have not proven to be carcinogenic. Risk analyses should be based on the avoidance of known adverse conditions, rather than pleural plaques per se.

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“…Ameille et al (41) in the French National Monitoring Program reported an estimated annual incidence of lung cancer in asbestos-exposed workers between 2,086 and 4,172 (1990) and an annual MPM incidence between 646 and 800 [1998][1999][2000][2001][2002][2003]. Moreover, it is known that the interaction between asbestos exposure and smoking habit has an additive or multiplicative effect for developing lung cancer (42).…”

Section: Discussionmentioning

confidence: 99%

Imaging of malignant pleural mesothelioma: it is possible a screening or early diagnosis program?—a systematic review about the use of screening programs in a population of asbestos exposed workers

Falaschi¹,

Romei²,

Fiorini

et al. 2018

J. Thorac. Dis.

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Malignant pleural mesothelioma (MPM) in an uncommon neoplasia with high mortality rate, mostly related to professional asbestos exposure. Clinical manifestations are not specific so that diagnosis is performed at advanced stage and screening protocols are not feasible now. On the other hand, asbestosexposed workers have a high incidence of developing lung cancer. Low-dose computed tomography (LDCT) is a volumetric acquisition technique with high spatial resolution and a low dose exposure; it is used in many trials to detect lung tumours at an early stage in screening protocols, reducing mortality rate in smoker subjects. In recent papers, the possibly role of lung cancer screening was evaluated and recommended also in subjects exposed to asbestos. This article summarizes previous and present clinical trials validated for lung cancer screening, to discuss the possibility of early diagnosis or screening programs in a population of asbestos exposed workers by LDCT.

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Occupational Asbestos Exposure and Lung Cancer—A Systematic Review of the Literature

Cited by 105 publications

References 92 publications

Asbestos-related lung cancers: A retrospective clinical and pathological study

Asbestos-related lung cancers: A retrospective clinical and pathological study

Are pleural plaques an appropriate endpoint for risk analyses?

Imaging of malignant pleural mesothelioma: it is possible a screening or early diagnosis program?—a systematic review about the use of screening programs in a population of asbestos exposed workers

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