Occupational Asbestos Exposure and Risk of Pleural Mesothelioma, Lung Cancer, and Laryngeal Cancer in the Prospective Netherlands Cohort Study

Offermans, Nadine S M; Vermeulen, Roel; Burdorf, Alex; Goldbohm, R. Alexandra; Kauppinen, Timo; Kromhout, Hans; Brandt, Piet A. van den

doi:10.1097/jom.0000000000000060

Cited by 52 publications

(53 citation statements)

References 35 publications

(23 reference statements)

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“…A previous study in the NLCS using DOMJEM was, however, able to corroborate the well-known association between asbestos and pleural mesothelioma. 7 Finally, several associations with overall gastric cancer and GNCA were reduced and became non-significant after adjusting for smoking status. Therefore, the assumption that potential confounders are only weakly correlated with asbestos exposure seems not totally justified.…”

Section: Colorectal Cancermentioning

confidence: 96%

“…6,7 Several exposure variables were defined: ever versus never exposed to asbestos (yes/no), duration of exposure (years), cumulative exposure (CE; unit-years), ever versus never highly exposed to asbestos (yes/no) and duration of high exposure (years).…”

Section: Occupational Exposure Assessmentmentioning

confidence: 99%

“…6,7 Results are presented in the Supporting Information Tables S4-S6, as well as a brief comparison of results of both JEMs.…”

Section: Sensitivity Analysismentioning

confidence: 99%

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Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

et al. 2014

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The evidence for an association between occupational asbestos exposure and esophageal, gastric and colorectal cancer is limited. We studied this association specifically addressing risk differences between relatively low and high exposure, risk associated with cancer subtypes, the influence of potential confounders and the interaction between asbestos and smoking in relation to cancer risk. Using the Netherlands Cohort Study (n 5 58,279 men, aged 55-69 years at baseline), asbestos exposure was estimated by linkage to a job-exposure matrix. After 17.3 years of follow-up, 187 esophageal, 486 gastric and 1,724 colorectal cancer cases were available for analysis. The models adjusted for age and family history of cancer showed that mainly (prolonged) exposure to high levels of asbestos was statistically significantly associated with risk of esophageal adenocarcinoma (EAC), total and distal colon cancer and rectal cancer. For overall gastric cancer and gastric non-cardia adenocarcinoma (GNCA), also exposure to lower levels of asbestos was associated. Additional adjustment for lifestyle confounders, especially smoking status, yielded non-significant associations with overall gastric cancer and GNCA in the multivariableadjusted model, except for the prolonged highly exposed subjects (tertile 3 vs. never: HR 2.67, 95% CI: 1.11-6.44 and HR 3.35, 95% CI: 1.33-8.44, respectively). No statistically significant additive or multiplicative interaction between asbestos and smoking was observed for any of the studied cancers. This prospective population-based study showed that (prolonged) high asbestos exposure was associated with overall gastric cancer, EAC, GNCA, total and distal colon cancer and rectal cancer.The International Agency for Research on Cancer evaluated the evidence for an association between asbestos exposure and gastric and colorectal cancer as limited, though for colorectal cancer they were evenly divided as to whether the evidence was strong enough to justify classification as sufficient. 1 For esophageal cancer, a relatively rare cancer, results of epidemiological studies on associations with asbestos are mixed and together with the fact that animal experiments do not support biological activity of asbestos at this site, the evidence was considered to be inadequate. 2 Therefore, the question remains whether asbestos entails an increased risk of developing gastrointestinal tumors, and if so, whether risk differs for relatively low and high exposure levels. As there are numerous other risk factors for gastrointestinal cancers, an additional question relates to the influence of potential confounders. Furthermore, cancer subtypes may have different etiologies and should be studied separately if possible. Finally, as for lung cancer, the question arises if interaction between asbestos and smoking is present in relation to gastrointestinal cancers. 1,2

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Section: Colorectal Cancermentioning

confidence: 96%

Section: Occupational Exposure Assessmentmentioning

confidence: 99%

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Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

et al. 2014

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“…Since HR of PhC and OCPC increased after adjustment for especially alcohol consumption and socioeconomic status, taking lifestyle factors into account may be important when studying these cancers. Furthermore, while our JEM-based exposure assessment possibly entailed non-differential exposure misclassification resulting most likely in bias towards the null value, a previous study in the NLCS using both DOMJEM and FINJEM was able to demonstrate the well-known associations between asbestos and cancers of the pleura and lungs (16). In addition, as study subjects were between 55-69 years of age at the start of the study in 1986, the amount of exposure misclassification resulting from the fact that we had no information on occupational history from 1986-2003 will probably be limited.…”

Section: Oral Cavity and Pharyngeal Cancer Combinedmentioning

confidence: 99%

“…were defined, which we have described in more detail elsewhere: ever versus never occupationally exposed to asbestos (yes/no), cumulative exposure [CE; a combined measure of the probability (P), intensity (I), and duration (years) of exposure, measured in fiber-years/ml (f-y/ ml) (FINJEM) or unit-years (DOMJEM)], ever versus never highly exposed to asbestos (yes/no), and duration of high exposure (years) (16).…”

Section: Asbestos Exposure Variables Several Exposure Variablesmentioning

confidence: 99%

Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study

Offermans¹,

Vermeulen²,

Burdorf³

et al. 2014

Scand J Work Environ Health

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Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study by Offermans NSM, Vermeulen R, Burdorf A, Goldbohm RA, Keszei AP, Peters S, Kauppinen T, Kromhout H, van den Brandt PA Within a population-based study, we estimate the association between occupational asbestos exposure and risk of oral cavity and pharyngeal cancer. There was no convincing evidence of an association between asbestos and risk of both cancers, as an exposure-response relation was lacking. However, the potentially increased hazard ratios of pharyngeal cancer observed in this and previous studies warrant further research. Original article Scand J Work Environ Health. 2014;40(4):420-427. doi:10.5271/sjweh.3434 Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study Objectives The evidence for an association between occupational asbestos exposure and pharyngeal cancer (PhC) is limited, while for oral cavity cancer (OCC) the literature is even sparser. We studied OCC and PhC risk both separately and combined (OCPC) in relation to occupational asbestos exposure, specifically addressing the influence of potential confounders, the existence of an exposure-response relation, and the presence of interaction between asbestos and smoking. AffiliationMethods Using the prospective Netherlands Cohort Study (N=58 279 men, aged 55-69 years), we estimated asbestos exposure by linkage to a general population job-exposure matrix (DOMJEM) and a Finnish job-exposure matrix (FINJEM). After 17.3 years of follow-up, 58 OCC and 53 PhC cases were available for analysis. ResultsNo association between asbestos and risk of OCC was observed for either JEM. Hazard ratios (HR) of PhC and OCPC increased after adjusting for confounders, particularly alcohol consumption and socioeconomic status. For PhC, a multivariable-adjusted increased HR was observed for "ever" versus "never" exposed to asbestos [HR 2.20, 95% confidence interval (95% CI) 1.08-4.49] when using FINJEM, but a trend of increased risks with higher cumulative exposure could not be demonstrated for either JEM. Results for OCPC showed patterns similar to those observed for PhC. None of the cancers showed a significant interaction between asbestos and smoking.Conclusions This prospective population-based study showed no convincing evidence of an association between asbestos and risk of OCC, PhC, and OCPC as an exposure-response relation was lacking, and results were not robust against the use of different JEM. However, the potentially increased HR of PhC and OCPC observed in this and previous studies warrant further research.

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Association Between Laryngeal Cancer and Asbestos Exposure

Ferster

Schubart

Kim

et al. 2017

JAMA Otolaryngol Head Neck Surg

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Although asbestos is considered hazardous and carcinogenic, current evidence is lacking to support a correlation between asbestos exposure and laryngeal cancer. Few studies have been able to definitively conclude a causal association between asbestos exposure and laryngeal cancer, and those that found an association often did not account for the confounding factors of tobacco and alcohol exposure.

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Occupational Asbestos Exposure and Risk of Pleural Mesothelioma, Lung Cancer, and Laryngeal Cancer in the Prospective Netherlands Cohort Study

Abstract: Asbestos levels encountered at the lower end of the exposure distribution may be associated with an increased risk of pleural mesothelioma, lung cancer, and laryngeal cancer.

Cited by 52 publications

References 35 publications

Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

Occupational asbestos exposure and risk of esophageal, gastric and colorectal cancer in the prospective Netherlands Cohort Study

Occupational asbestos exposure and risk of oral cavity and pharyngeal cancer in the prospective Netherlands Cohort Study

Association Between Laryngeal Cancer and Asbestos Exposure

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