Occupational asthma

Heat shock protein (hsp 70)-related epitopes are common allergenic determinants for barley and corn antigens

“…A comparison of the epitopes results in a clear correlation of cross reactivity between suspected antigens [5]. Prevalent studies of serological examination of allergens may exhibit the effect on health caused by bioaerosol exposure, as well as the common allergenic proteins from different sources [6]. Over 50% of the feeds used on pig farms is made of corn flour; therefore, it is reasonable to consider this a possible work-related allergic bioaerosol on pig farms.…”

A revised nomenclature for allergy: An EAACI position statement from the EAACI nomenclature task force

“…Some individuals that cannot be described as atopic escape sensitization to common allergens in childhood and adolescence, but develop IgE‐mediated allergy later in life when exposed to high doses of allergen, often together with some adjuvant, such as tobacco smoke (66). This situation is illustrated by many cases of occupational allergy (74), as to laboratory animals such as mice (90), enzymes such as α‐amylase (11, 101), Bacillus subtilis protease (95), and houseplants such as Ficus benjamina (7, 78). There are some indications that, in addition to the IgE trait, atopy includes some kind of target organ sensitivity, as shown, for example, by the adverse effect of exercise in some patients, the finding of nonallergen‐specific bronchial hyperreactivity in patients with allergic asthma, and the disturbed barrier function of atopic skin.…”

A prospective study of the relationship between exposure and specific antibodies in workers exposed to organic acid anhydrides

“…Many proteins and low‐molecular‐weight chemicals have the potency to induce allergic sensitization of the airways including the formation of specific IgE antibodies (1). However, very little is known about the relationship between the dose of allergen and sensitization (2, 3).…”