Occupational asthma after exposure to<i>ortho</i>-phthalaldehyde (OPA)

Robitaille, Catherine; Boulet, Louis‐Philippe

doi:10.1136/oemed-2015-102847

Cited by 14 publications

(13 citation statements)

References 5 publications

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“…Although the effect of chronic exposure to chemicals cannot be investigated experimentally, it is interesting to note that at least the adjuvant effect of formaldehyde was observed at low concentrations 59,60 . A similar, dual role with both adjuvant and irritant effects could be hypothesized for other asthmagenic chemicals (eg, ortho-phthalaldehyde or quaternary ammonium compounds) for which specific-IgE response has not been evidenced or is rarely observed, but an adjuvant role has been suggested 33,58,[61][62][63][64] . Hypotheses regarding the mechanisms underlying the adjuvant effect involve injury of the airway epithelium and increased permeability, facilitating the crossing of the epithelial barrier by allergens 46,60,65 .…”

Section: Biological Plausibility Of Iia Caused By Chronic Exposure Tomentioning

confidence: 73%

Do chronic workplace irritant exposures cause asthma?

Dumas

Moual

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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Evidence of a causal effect of chronic workplace irritant exposure in new-onset asthma remains limited, mainly because of a lack of longitudinal studies and the difficulty to evaluate irritant exposures. However, recent epidemiological studies strengthen the evidence of an effect of chronic exposure to irritants in work-related asthma. The underlying mechanism remains unknown but may be related to oxidative stress, neurogenic inflammation and dual irritant and adjuvant effects. However, disentangling chronic irritant effects from either acute irritant-induced asthma or immunological low molecular weight agent-induced asthma is difficult for some agents. Further research is needed to improve assessment of irritant exposures and identify biomarkers.

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Section: Biological Plausibility Of Iia Caused By Chronic Exposure Tomentioning

confidence: 73%

Do chronic workplace irritant exposures cause asthma?

Dumas

Moual

2016

Current Opinion in Allergy &Amp; Clinical Immunology

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“…Among biocides, ortho-phthalaldehyde (OPA) is an aromatic dialdehyde that has largely replaced glutaraldehyde as a new high-level disinfectant for heat-sensitive medical devices, including endoscopes. OA-induced by OPA was documented by a positive SIC with a delayed asthmatic response (43% fall in FEV1 4 h after exposure) in a worker employed in endoscopic unit [45]. A few cases of OA were also reported with peracetic acid-hydrogen peroxide mixture, an alternative of aldehydes used as disinfectants for endoscopes in hospitals [46,47].…”

Section: Oa-induced By Lmw Sensitizing Agentsmentioning

confidence: 99%

Progress in Occupational Asthma

Tiotiu

Novakova²,

Labor

et al. 2020

IJERPH

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Occupational asthma (OA) represents one of the major public health problems due to its high prevalence, important social and economic burden. The aim of this review is to summarize current data about clinical phenotypes, biomarkers, diagnosis and management of OA, a subtype of work-related asthma. Most studies have identified two phenotypes of OA. One is sensitizer-induced asthma, occuring after a latency period and caused by hypersensitivity to high- or low-molecular weight agents. The other is irritant-induced asthma, which can occur after one or more exposures to high concentrations of irritants without latency period. More than 400 agents causing OA have been identified and its list is growing fast. The best diagnostic approach for OA is a combination of clinical history and objective tests. An important tool is a specific inhalation challenge. Additional tests include assessments of bronchial hyperresponsiveness to methacholine/histamine in patients without airflow limitations, monitoring peak expiratory flow at- and off-work, sputum eosinophil count, exhaled nitric oxide measurement, skin prick tests with occupational allergens and serum specific IgE. Treatment of OA implies avoidance of exposure, pharmacotherapy and education. OA is a heterogeneous disease. Mechanisms of its different phenotypes, their diagnosis, role of new biomarkers and treatment require further investigation.

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“…Some cleaning agents can induce sensitization by an immunologic mechanism and cause allergic rhinitis or asthma. Positive bronchial and nasal provocation tests have been reported for chloramine-T 29,30 , quaternary ammonium salts 31,32 , triclosan 33 , amines 34 , glutaraldehyde 6 , ortho-phthalaldehyde 35 , fragrances 36 and enzymes 37,38 . An IgE-mediated mechanism has been suggested for very few compounds, such as chloramine-T 39 , ortho-phthalaldehyde 40 and enzymes 37 .…”

Section: Sensitizer-induced (Allergic) Rhinitis and Asthmamentioning

confidence: 99%

Respiratory Health Effects of Exposure to Cleaning Products

Matteis

Ronsmans

Nemery

2020

Clinics in Chest Medicine

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Cleaning-related respiratory health effects are an important occupational and public health issue • A wide variety of respiratory symptoms and conditions have been reported• Many cleaning agents have hazardous properties which may lead to health effects via several underlying mechanisms• Preventive measures to avoid the cleaning-related respiratory health burden are warranted SYNOPSISThere is consistent and growing evidence of an epidemic of 'asthma-like' symptoms among professional cleaners. Important questions remain unanswered: how big is this problem worldwide, which cleaning agents are dangerous, and how do they affect the lungs, is it really 'asthma'? This is an important public health issue because of the large and increasing number of professional cleaners (c.4 million in Europe only), many from 'vulnerable' categories, such as women, immigrants, and of low socio-economic status. In addition, there are potential implications for anybody exposed to cleaning products during routine domestic housekeeping, including children. In this chapter we will try to address these issues using the available evidence on this topic, from epidemiology to toxicology, to give a broad but concise overview on what we know so far and how we could prevent the cleaning-associated respiratory health public burden.

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Occupational asthma after exposure toortho-phthalaldehyde (OPA)

Cited by 14 publications

References 5 publications

Do chronic workplace irritant exposures cause asthma?

Do chronic workplace irritant exposures cause asthma?

Progress in Occupational Asthma

Respiratory Health Effects of Exposure to Cleaning Products

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