Occupational Asthma Caused by Inhalation of Bovine Serum Albumin Powder

Choi, Gil-Soon; Kim, Joohee; Lee, Haet-Nim; Sung, Jun-Mo; Lee, Jin Woo; Park, Hae‐Sim

doi:10.4168/aair.2009.1.1.45

Cited by 27 publications

(15 citation statements)

References 9 publications

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“…It is generally assumed that they are of low relevance. However, two cases of occupational asthma triggered by inhalation of Bos d 6 have been reported in a laboratory worker . High levels of IgE antibodies to Fel d 2 have been associated with atopic dermatitis in cat‐allergic children .…”

Section: Clinical Relevancementioning

confidence: 99%

EAACI Molecular Allergology User's Guide

Matricardi

Kleine-Tebbe²,

Hoffmann

et al. 2016

Pediatric Allergy Immunology

740

870

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The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

show abstract

Section: Clinical Relevancementioning

confidence: 99%

EAACI Molecular Allergology User's Guide

Matricardi

Kleine-Tebbe²,

Hoffmann

et al. 2016

Pediatric Allergy Immunology

740

870

View full text Add to dashboard Cite

show abstract

“…A specific IgE level >0.35 KU/l was considered positive. BSA‐specific IgE levels were measured by ELISA using a previously described method (3). The positive cut‐off value for a high serum BSA‐specific IgE antibody level was defined as the mean ± 3 standard deviations of the absorbance value for nonatopic healthy controls.…”

Section: Clinical Features and Immunological Findings Of The Study Smentioning

confidence: 99%

Food allergy to meat and milk in adults

Choi¹,

Kim²,

Shin³

et al. 2010

Allergy

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“…Choi et al [5] reported a case of occupational asthma and rhinitis caused by inhalation of BSA powder in which an IgE-mediated response was suggested as the pathogenetic mechanism by inhalation challenge and immunologic studies. Interestingly, it was demonstrated that the individual experienced milk-induced food allergy symptoms only after the onset of bronchospasm, so the primary route of sensitization likely was via BSA inhalation, not via BSA ingestion.…”

Section: Characteristics Of Allergic Sensitization To Serum Albumins mentioning

confidence: 98%

Role of Sensitization to Mammalian Serum Albumin in Allergic Disease

Liccardi

Asero

D’Amato

et al. 2011

Curr Allergy Asthma Rep

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Serum albumin (SA) constitutes an intriguing puzzle that is involved in allergic sensitizations from different sources and induces different clinical manifestations. In this article, we describe the role of sensitization to SAs in inducing allergic diseases and the complex interactions and cross-reactivity between SA resulting from its presence in various mammalian tissues and fluids. SAs alone are an uncommon cause of allergic sensitization in airways, but these allergenic proteins likely play a significant role as cross-reacting allergens in individuals sensitized to several types of animal dander. SAs are a minor allergen in milk but a major allergen in meats. Recently, bovine SA has been added to the culture medium of spermatozoids used for artificial insemination. As a consequence, some case reports have shown that bovine SA may be a causative agent in severe anaphylaxis after standard intrauterine insemination or in vitro fertilization.

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Occupational Asthma Caused by Inhalation of Bovine Serum Albumin Powder

Cited by 27 publications

References 9 publications

EAACI Molecular Allergology User's Guide

EAACI Molecular Allergology User's Guide

Food allergy to meat and milk in adults

Role of Sensitization to Mammalian Serum Albumin in Allergic Disease

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