Occupational Asthma Caused by Nickel and Zinc

Hong, Chein Soo; Oh, Seung Heon; Huh, Kap Bum; Lee, Sang Yong

doi:10.3904/kjim.1986.1.2.259

Cited by 10 publications

(4 citation statements)

References 3 publications

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“…Various metals such as chromium, nickel, cobalt, iron, zinc can induce OA in metal-plating workers and welders of stainless steel, but the most frequent cause is the sensitization to platinum salts in metal refinery industry, manufacture of catalysts or cytotoxic drugs [31][32][33][34][35]. IgE-mediated mechanism has been suggested for most of these metals only for platinum salts sIgE could be detected [32][33][34]. The SIC is usually necessary for the confirmation of OA [35].…”

Section: Oa-induced By Lmw Sensitizing Agentsmentioning

confidence: 99%

Progress in Occupational Asthma

Tiotiu

Novakova²,

Labor

et al. 2020

IJERPH

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Occupational asthma (OA) represents one of the major public health problems due to its high prevalence, important social and economic burden. The aim of this review is to summarize current data about clinical phenotypes, biomarkers, diagnosis and management of OA, a subtype of work-related asthma. Most studies have identified two phenotypes of OA. One is sensitizer-induced asthma, occuring after a latency period and caused by hypersensitivity to high- or low-molecular weight agents. The other is irritant-induced asthma, which can occur after one or more exposures to high concentrations of irritants without latency period. More than 400 agents causing OA have been identified and its list is growing fast. The best diagnostic approach for OA is a combination of clinical history and objective tests. An important tool is a specific inhalation challenge. Additional tests include assessments of bronchial hyperresponsiveness to methacholine/histamine in patients without airflow limitations, monitoring peak expiratory flow at- and off-work, sputum eosinophil count, exhaled nitric oxide measurement, skin prick tests with occupational allergens and serum specific IgE. Treatment of OA implies avoidance of exposure, pharmacotherapy and education. OA is a heterogeneous disease. Mechanisms of its different phenotypes, their diagnosis, role of new biomarkers and treatment require further investigation.

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Section: Oa-induced By Lmw Sensitizing Agentsmentioning

confidence: 99%

Progress in Occupational Asthma

Tiotiu

Novakova²,

Labor

et al. 2020

IJERPH

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“…Cases tend to be isolated to individuals working in occupations involving metalwork where metal fumes, dust, or vapors are generated and inhaled (Wyman and Hines 2018). Nickel, chromium, cobalt, vanadium, zinc, platinum and aluminum have all been associated with cases of occupational asthma (Musk and Tees 1982; Hong et al 1986; Malo et al 2013). However, metal-specific IgE has only been implicated in cases caused by nickel, platinum, chromium, and cobalt (Malo et al 1982; Murdoch et al 1986; Shirakawa et al 1988, 1990, 1992; Kusaka et al 1996).…”

Section: Metals and Allergic Diseasementioning

confidence: 99%

Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease

Roach

Stefaniak

Roberts

2019

Journal of Immunotoxicology

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The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings have raised concerns over the potential for metals to induce size-specific adverse toxicological effects. Although nano-metals have been shown to induce greater lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are historically recognized as common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy. The investigation into the potential for adverse immune effects following exposure to metal nanomaterials is becoming an area of scientific interest since these characteristically lightweight materials are easily aerosolized and inhaled, and their small size may allow for penetration of the skin, which may promote unique size-specific immune effects with implications for allergic disease. Additionally, alterations in physicochemical properties of metals in the nano-scale greatly influence their interactions with components of biological systems, potentially leading to implications for inducing or exacerbating allergic disease. Although some research has been directed toward addressing these concerns, many aspects of metal nanomaterial-induced immune effects remain unclear. Overall, more scientific knowledge exists in regards to the potential for metal nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Current knowledge regarding metal nanomaterials and their potential to induce/ exacerbate dermal and respiratory allergy are summarized in this review. In addition, an examination of several remaining knowledge gaps and considerations for future studies is provided.

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“…Nickel salt exposure can cause asthmatic symptoms. Most of the cases were observed in workers in the electroplating industry, where exposure is primarily to soluble nickel salts (McConnell et al, 1973;Malo et al, 1982;Novey et al, 1983;Malo et al, 1985;Hong et al, 1986). The significance of this apparent specificity is unclear.…”

Section: Human Noncancer Datamentioning

confidence: 99%