Occupational asthma due to an emulsified oil mist.

Hendy, Moataz S.; Beattie, Benjamin; Burge, P. S.

doi:10.1136/oem.42.1.51

Cited by 45 publications

(36 citation statements)

References 5 publications

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“…A survey of TRPA1 tissue distribution was done using the mouse gene expression database (GXD) (http://www.informatics.jax.org) (18,19).…”

Section: Resultsmentioning

confidence: 99%

Detection of Murine TRPA1 Transcripts in Keratinocytes

Kwan

2016

J Skin Stem Cell

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Background: Transient receptor potential ankyrin 1 (TRPA1) is expressed by nociceptive neurons of the dorsal root ganglia (DRGs) and trigeminal ganglia, but its expression in other cell types is largely unexplored. TRPA1 contributes to chemical, mechanical and cold nociception and expression of TRPA1 in keratinocytes may extend the detection of chemical and physical stimuli from the nerve endings to the surface of the skin. Results: Comparison of TRPA1 genes from multiple inbred mouse lines revealed a large number of genetic variations in the TRPA1 locus. These genetic variations may affect annealing of primers to detect TRPA1 transcript when using nucleic acid-based methods. To consistently detect TRPA1 in genetically diverse mouse strains and in different tissue types, an optimized qPCR protocol for TRPA1 detection was created. Conclusions: TRPA1 transcripts are consistently detected in murine keratinocytes.

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“…A survey of TRPA1 tissue distribution was done using the mouse gene expression database (GXD) (http://www.informatics.jax.org) (18,19).…”

Section: Resultsmentioning

confidence: 99%

Detection of Murine TRPA1 Transcripts in Keratinocytes

Kwan

2016

J Skin Stem Cell

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“…Once used, metalworking fluids may be contaminated with bacterial and fungal microbes, hydraulic fluid, added biocides, dissolved metals and other manufacturing by-products, all of which are potential sensitisers for occupational asthma, as well as causes of extrinsic allergic alveolitis, humidifier fever and occupational bronchitis [13,14]. SIC testing to metalworking fluids has been undertaken safely, though positive tests are much more common to used metalworking fluids than to clean metalworking fluids [15,16]. 4,4-methylene-bismorpholine has a high asthma hazard index (maximum 1.0) using the Manchester Occupational Asthma Hazard Programme, which has a high sensitivity in identifying novel asthmagens [17].…”

Section: T W T F S S M T W T F S S M T W T F S S M T W M T W T F S Smentioning

confidence: 99%

Occupational asthma from sensitisation to 4,4-methylene-bismorpholine in clean metalworking fluid

Walters¹,

Moore²,

Robertson³

et al. 2013

Eur Respir J

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“…presented a case report of a tool setter occupationally exposed to different oils, including pine oil, who developed asthmatic reaction due to pine oil [6].…”

Section: Introductionmentioning

confidence: 99%

Occupational asthma due to turpentine in art painter — case report

Dudek

Wittczak²,

Świerczyńska-Machura³

et al. 2009

International Journal of Occupational Medicine and Environmental Health

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Turpentine is a fluid obtained by distillation of wood resins containing mixture of terpens. It can act as an irritant and sensitiser. Most common health problem among workers exposed to turpentine is contact dermatitis. Little is know about turpentine to cause type I hypersensitivity reaction. We present a case of a 27-year old art painter using turpentine as a thinner for oil-based paints. She developed asthmatic reactions after 5 years of working with turpentine. A number of clinical procedures were performed, including clinical examination, routine laboratory tests, total serum IgE, skin prick tests to common aeroallergens, metal salts, oil-based paints and balsamic turpentine, resting spirometry test, histamine challenge, and a single-blind, placebo-controlled specific inhalation challenge with balsamic turpentine. Clinical findings and laboratory test results were normal but a significant bronchial hyperreactivity was found. During the specific challenge, dyspnoea and decreased forced expiratory volume (FEV 1 ) were observed in late phase of asthmatic reaction. An increased proportion of eosinophils in induced sputum could also be noted 24 h after the challenge. Positive clinical response to the specific challenge as well as the morphological changes found in induced sputum served as the basis for diagnosing occupational asthma. To our knowledge, this is the first well-documented case of turpentine-induced occupational asthma.

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Occupational asthma due to an emulsified oil mist.

Cited by 45 publications

References 5 publications

Detection of Murine TRPA1 Transcripts in Keratinocytes

Detection of Murine TRPA1 Transcripts in Keratinocytes

Occupational asthma from sensitisation to 4,4-methylene-bismorpholine in clean metalworking fluid

Occupational asthma due to turpentine in art painter — case report

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