Occupational Bladder Tumour Cases Identified During Ten Years' Interviewing of Patients

Davies, J M; Somerville, Sheena M.; Wallace, David

doi:10.1111/j.1464-410x.1976.tb06702.x

Cited by 11 publications

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“…The role of occupational exposure to chemicals in the aetiology of bladder cancer has been studied extensively [ 1]. Reviews of this literature have provided estimates of the proportions of bladder tumours which might be attributed to such exposures [ 2–4] and an overview by Doll and Peto noted that ‘Figures of 10% in men and 5% in women ... are not likely to be far out’ [ 5]. The objectives of the present case‐control study were threefold: first, to determine whether occupational exposures remain an important cause of recently diagnosed cases of urothelial cancer; second, to identify occupations for which further assessment or control is necessary; and third, to identify occupations which present unrecognized risks of urothelial tumours.…”

Section: Introductionmentioning

confidence: 99%

Occupational urothelial tumours: a regional case study

Sorahan¹,

Hamilton²,

Wallace

et al. 1998

British Journal of Urology

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Objective To investigate the role of occupational exposures in the risk of developing urothelial cancer. Materials and methods Occupational histories, obtained using a self‐administered questionnaire, for 803 patients with urothelial cancer (first diagnosed 1991–93) were compared with similar information for 2135 matched controls. Relative risks (RRs) were estimated using conditional logistic regression. Comparisons were also made with historical regional employment information available from the 1971 census. Results There were many statistically significant positive associations for urothelial cancer risks and ever being employed in specified occupations (with or without statistical adjustment for smoking status in 1991). Smoking‐adjusted RRs of >2.0 were obtained for seven occupations; manufacture of fire lighters/ patent fuels (RR 4.30, 95% confidence interval 0.78–23.79), rodent extermination (3.71, 1.20–11.48), manufacture of dyestuffs (2.61, 0.98–7.00), leather work (2.51, 1.44–4.35), cable manufacturing industry (2.46, 1.20–5.04), textile printing and dyeing (2.32, 0.98–5.45), and sewage works (2.19, 1.16–4.11). Analyses of the occupations followed in 1971 (thus allowing for 20‐year latency) indicated an elevated RR for workers in the plastics industry (5.22, 1.57–17.36). Conclusions The historical legacy of exposure to aromatic amines in the rubber, cable‐making, dyestuffs and other industries remains. An important proportion of patients presenting with urothelial tumours are likely to have had occupational exposure to urothelial carcinogens. A review of occupational exposures in the contemporaneous plastic, textile and leather industries is warranted.

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Section: Introductionmentioning

confidence: 99%

Occupational urothelial tumours: a regional case study

Sorahan¹,

Hamilton²,

Wallace

et al. 1998

British Journal of Urology

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“…This is well under 1% of the incidence of urothelial cancer (Glashan, 1982). In a detailed study of the occupational histories of urothelial cancer patients at the Royal Marsden Hospital, Davies et al (1976) found that 10% had histories suggesting industrial exposure but only 4% justified claims for PD Benefit. Because of the special interests of this hospital and referral practice this series was inevitably highly selected.…”

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confidence: 99%

Occupational Urothelial Cancer

Wallace

1988

British Journal of Urology

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Case, R. A. M. (1983). The misbegotten camel: notes on the scheduling of neoplasm of the urothelium (as P D 39. "Papilloma of the Bladder") in 1953; on the withdrawal from the selling range of ICI Ltd of certain rubber additives suspected of possessing carcinogenic properties around 1949, and the relationship of this to claims for Prescribed Industrial Disease Benefit and for damages, and to problems raised in the Report on PD C23. (Unpublished report). Case, R. A. M. and Hosker, M. E. (1954). Tumour of the urinary bladder as an occupational disease in the rubber industry in England and Wales. Br. J. Prev. Med. Soc., 8,39-50. Case, R. A. M., Hosker, M. E., McDonald, D. B. er al. (1954).Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. Brit. J . Ind. Med.,

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“…Die Beobachtungen wurden in den folgenden Jahrzehnten auch auf andere Indu striezweige ausgeweitet, so daß bestimmte Berufsgruppen mit einem erhöhten Blasentumorrisiko festgestellt werden konn ten. Es handelte sich hierbei im wesentlichen um Arbeiter bestimmter chemischer Industriezweige der Kabel-, Reifen-, Gummi-, Gas-, Leder-und Farbstoffindustrie [20,32,33,42]. Etwa 18% der Harnblasenkarzinome dürften bei Männern durch diese industriellen Karzinogene verursacht werden; für Frauen liegen die Angaben mit 6 % deutlich niedriger [27].…”

Section: äTiologische Faktorenunclassified

Epidemiologie und Pathogenese des Harnblasenkarzinoms

Adolphs¹,

Thiele²,

Vahlensieck³

1980

Oncol Res Treat

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Zunächst werden alle bekannten und in der wissenschaftlichen Dis-kussion stehenden ätiologischen Faktoren für die Entstehung eines Harnblasenkarzinoms aufgeführt. Es handelt sich unter anderem um industrielle Karzinogene, Tryptophan-Abbauprodukte, Phenazetin, Nikotin, Kaffee, Süßstoffe und chronische Reizzustände des Blasen-urothels. Zusätzlich werden die aus der Literatur bekannten demo-graphischen Faktoren wie familiäre, geographische, geschlechtliche und rassische Dispositionen diskutiert. Ein weiterer Abschnitt be-handelt die frühen histologischen Veränderungen des Harnblasen-urothels bis hin zur Tumormanifestation, wobei speziell auf die Be-deutung des Carcinoma in situ hingewiesen wird.

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Occupational Bladder Tumour Cases Identified During Ten Years' Interviewing of Patients

Cited by 11 publications

References 1 publication

Occupational urothelial tumours: a regional case study

Occupational urothelial tumours: a regional case study

Occupational Urothelial Cancer

Epidemiologie und Pathogenese des Harnblasenkarzinoms

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