Occupational cancer genetics: infrequent <i>ras</i> oncogenes point mutations in lung cancer samples from chromate workers

Ewis, Ashraf A.; Kondo, Kazuya; Lee, Juwon; Tsuyuguchi, Masaru; Hashimoto, Masato; Yokose, Tomoyuki; Mukai, Kiyoshi; Kodama, T; Shinka, Toshikatsu; Monden, Yasumasa; Nakahori, Yutaka

doi:10.1002/ajim.1075

Cited by 31 publications

(17 citation statements)

References 29 publications

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“…In some cases, for example, in chromate-related lung cancer, no mutations in RAS genes were found. The reason that no mutations were detected in these chromate-related lung cancer samples is that almost all chromate lung cancers were proved pathologically to be of the small cell cancer type, in which RAS genes rarely mutate [57]. This is consistent with previous studies that reported infrequent RAS-genes mutations in the small cell cancer pathological type of lung cancer samples, while adenocarcinoma was the pathological type that showed a high percentage of mutated RAS genes [58].…”

Section: Ras Mutationssupporting

confidence: 91%

Molecular Fingerprints of Environmental Carcinogens in Human Cancer

Ceccaroli

Pulliero

Geretto

et al. 2015

Journal of Environmental Science and Health, Part C

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Identification of specific molecular changes (fingerprints) is important to identify cancer etiology. Exploitable biomarkers are related to DNA, epigenetics, and proteins. DNA adducts are the turning point between environmental exposures and biological damage. DNA mutational fingerprints are induced by carcinogens in tumor suppressor and oncogenes. In an epigenetic domain, methylation changes occurs in specific genes for arsenic, benzene, chromium, and cigarette smoke. Alteration of specific microRNA has been reported for environmental carcinogens. Benzo(a)pyrene, cadmium, coal, and wood dust hits specific heat-shock proteins and metalloproteases. The multiple analysis of these biomarkers provides information on the carcinogenic mechanisms activated by exposure to environmental carcinogens.

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Section: Ras Mutationssupporting

confidence: 91%

Molecular Fingerprints of Environmental Carcinogens in Human Cancer

Ceccaroli

Pulliero

Geretto

et al. 2015

Journal of Environmental Science and Health, Part C

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“…Our previous studies have investigated the alterations of oncogenes, tumor suppressor genes, and DNA mismatch repair genes in lung cancer from chromate-exposed workers [6][7][8][9]. Our study demonstrated that LOH at the p16 locus (D9S161) was common not only in non-chromate lung cancer, but also chromate lung cancers (54% versus 78%) [8].…”

Section: Discussionmentioning

confidence: 54%

“…However, its genetic effects in humans are only partially understood. On the other hand, our previous study examined p53 and ras mutations, genetic instability, and the inactivation of hMLH1 expression in human chromate lung cancer [6][7][8][9]. Our previous study demonstrated that the loss of heterozygosity (LOH) at the 9p21 region (D9S161 marker) was more common in lung cancer patients with chromate exposure than in lung cancer patients without (78% versus 54%) [8].…”

Section: Introductionmentioning

confidence: 94%

The reduced expression and aberrant methylation of p16INK4a in chromate workers with lung cancer

et al. 2006

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“…27,28 There was no significant difference in loss of heterozygosity (LOH) at 3p between chromate-induced lung carcinomas and non-chromate-induced lung carcinomas. 13 In contrast, the frequency of RER in chromate-induced lung carcinomas (78.9%) was significantly higher than in non-chromate-induced lung carcinoma (15.4%).…”

Section: Discussionmentioning

confidence: 99%

Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers

Kondo

Takahashi

Ishikawa

et al. 2003

Cancer

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BACKGROUNDIt is known that chromium is an inhaled carcinogen and an important risk factor in the development of lung carcinoma.METHODSThe authors used a microscopic X‐ray fluorescence analyzer with transmitted X‐ray mapping imaging (Horiba, Kyoto, Japan) to measure the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers.RESULTSThe maximum chromium accumulation (mean ± standard deviation) in 10 resected lung tissue specimens was 197 ± 238 counts per second (cps)/mili ampere (mA) (range, 4–649 cps/mA). Chromium accumulation was scattered in six tissue specimens and diffuse in one specimen. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. Chromium accumulation was detectable in 63 (70%) of 90 biopsy specimens, and the mean accumulation was 6.5 ± 9.2 cps/mA (range, 0–46.5 cps/mA). Chromium detected in bronchial tissue specimens was deposited in the bronchial stroma but not in the epithelium. The maximum chromium accumulations in dysplasic (n = 3), squamous metaplastic (n = 10), and normal bronchial epithelia (n = 9) in chromate workers and in normal bronchial epithelia (n = 3) in non‐chromate workers were 20.2 ± 5.4, 18.3 ± 12.2, 13.2 ± 13.4, and 3.0 ± 1.8 cps/mA, respectively. The amount of chromium accumulation significantly increased according to the progression of malignant change of the bronchial epithelium (P = 0.003).CONCLUSIONSPrevious studies found that lung carcinoma with chromate exposure exhibited a variety of genetic abnormalities. Considering genetic aberrations and chromium accumulation in these premalignant lesions is useful for elucidating the process of carcinogenesis in chromium‐induced lung carcinoma. Cancer 2003. © 2003 American Cancer Society.

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Occupational cancer genetics: infrequent ras oncogenes point mutations in lung cancer samples from chromate workers

Abstract: Ras oncogenes activated by point mutations do not have a major role in the process of tumorigenesis of chromate-related lung cancer.

Cited by 31 publications

References 29 publications

Molecular Fingerprints of Environmental Carcinogens in Human Cancer

Molecular Fingerprints of Environmental Carcinogens in Human Cancer

The reduced expression and aberrant methylation of p16INK4a in chromate workers with lung cancer

Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers

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