Occupational contact allergens: Are they also associated with occupational asthma?

Abstract

Several common OCAs can also potentially cause OA. Inhalation and dermal exposures to these agents should be controlled and both OA and AOCD should be considered as possible health outcomes. Increased consistency in sensitizer notations is needed.

Recent Trends in Occupational Contact Dermatitis

“…Some common occupational contact allergens were determined to be established or possible causes of occupational asthma (epoxy resin, nickel sulate, cobalt chloride, potassium dichromate, PPD, formaldehyde, and glutaraldehyde), whereas for thiuram, carba mix, and glyceryl thioglycolate, no evidence of an association with occupational asthma was found [10]. It was reported that subjects with a history of eczema had significantly greater odds of reporting both work-related skin and respiratory symptoms.…”

Evaluation of skin and respiratory symptoms among employees with exposure to metals, metalworking fluids, and noise at an orthopedic implant manufacturer.

“…Some studies have shown that low levels of cobalt can lead to a decrease in lung function [Rehfisch et al 2015]. Other study findings indicate that skin exposure to cobalt and other sensitizing chemicals may lead to an asthma-like response [Sjogrens et al 1980;Arrandale et al 2012]. About 90% of absorbed cobalt is eliminated rapidly within a few days; about 10% is eliminated with a biological half-life of about 2 years [ACGIH 2001].…”

Review of Occupational Contact Dermatitis—Top Allergens, Best Avoidance Measures

“…-A recent (2012) study from Canada not only endorsed these allergens, but also reported additional occupational allergens: glyceryl thioglycolate, para-phenylenediamine, glutaraldehyde, cobalt chloride, and potassium dichromate [18]. …”