Occupational contact allergy to tetrazepam

Occupational airborne contact allergy to tetrazepam

“…The usefulness of patch tests was shown in all previous reports, not only in the case of orally induced tetrazepam allergy but also when contact allergy was suspected (1–4). In our case, we again describe an occupational airborne contact allergy in a geriatric nurse who had to work with crushed tablets.…”

“…In our case, we again describe an occupational airborne contact allergy in a geriatric nurse who had to work with crushed tablets. 2 cases of contact allergy in a pharmaceutical factory working with tetrazepam powder (2) and 1 case of a woman crushing tablets with her fingers (3) have previously been reported. Thus, not only repeated handling of the drug but more particularly contact with powders and crushed tablets seems to be a risk factor for the development of a contact allergy to tetrazepam.…”

Occupational airborne contact allergy to tetrazepam in a geriatric nurse

“…In the literature predominantly exanthemas after use of tetrazepam are reported [4, 5]. To date five cases of airborne allergic contact dermatitis due to tetrazepam have been reported, among others in the pharmaceutical industry [5, 6]. The case of a geriatric nurse who developed cutaneous lesions on exposed skin after pulverizing tetrazepam tablets has been reported [7].…”

“…In other cases of allergic exanthemas or allergic contact dermatitis patch testing or provocation testing with further benzodiazepines revealed no test reactions [4–6, 10]. Oral provocation testing with alternative benzodiazepines was only performed in one patient with allergic contact dermatitis [7]; provocation with midazolam was well‐tolerated here; after exposition with flunitrazepam conjunctival symptoms developed which were attributed to the grass pollen release.…”

Occupational allergic contact dermatitis from tetrazepam in nurses

“…Both allergic contact dermatitis and drug eruptions following ingestion of tetrazepam have been described in the literature. In our search (PubMed) we found seven cases of occupational allergic contact dermatitis from tetrazepam: one occurred in a mother crushing Myolastan ® tablets for her daughter (1), three in nurses (2–4), and three in pharmaceutical manufacturing workers (5, 6). All patients suffered from airborne contact dermatitis with lesions on the face and neck, and three of them also had erythema or eczema on the fingers and dorsum of the hands.…”