Occupational Contact Dermatitis

Coman, Garrett; Zinsmeister, Chris; Norris, Patricia

doi:10.1097/der.0000000000000142

Cited by 16 publications

(5 citation statements)

References 17 publications

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“…The prevalence of sensitization in the total population was calculated to be 2.02% [ 23 ], while male WhC prevalence was 0.71%, much lower than that reported from other studies and in particular 4.8% [ 24 ]. Also, thiuram mix 1% was uniquely positive in BlC males and BlC females which is in agreement with previous studies for workers (BlC) [ 7 , 25 , 26 ]. Finally, paraphenylenediamine 1% was uniquely positive in BlC females, BlC males, and WhC females.…”

Section: Discussionsupporting

confidence: 93%

Analysis of Prevalence and Risk Factors of Contact Sensitization with respect to the Occupational Profiles in a Greek Patient Cohort: A Retrospective Analysis of a Greek Referral Centre and Future Perspectives

Tagka

Lambrou

Matsopoulos

et al. 2021

BioMed Research International

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Contact dermatitis is a frequent skin disorder related to environmental and occupational etiological factors, which could potentially affect all age groups, as well as both genders. The current study is aimed at exploring the patterns of contact sensitization with respect to the population’s occupational patterns in Greece. A retrospective analysis was performed in a cohort of 1978 patients from 2014 to 2016. Patients were divided into two categories; blue collars (BlC) and white collars (WhC), as well as detailed occupation was considered. Separation was performed on the basis of their profession, i.e., labor workers and handicraftsmen were sorted to the BlC group, while office employees were sorted to the WhC group. The common allergen in all occupational subgroups was nickel sulphate. The three most prevalent allergens in both BlC and WhC were nickel sulphate 5%, fragrance mix (I) 8%, and Balsam of Peru 25%. WhC males were uniquely sensitized to colophony 20% and formaldehyde 2%, and WhC females were uniquely sensitized to 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and neomycin sulphate 20%. Sensitization to allergens manifested occupation-specific patterns. Allergic contact dermatitis surveillance is of great importance towards the clinical and systematic understanding of the disease, especially with respect to the patient’s occupational profile.

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Section: Discussionsupporting

confidence: 93%

Analysis of Prevalence and Risk Factors of Contact Sensitization with respect to the Occupational Profiles in a Greek Patient Cohort: A Retrospective Analysis of a Greek Referral Centre and Future Perspectives

Tagka

Lambrou

Matsopoulos

et al. 2021

BioMed Research International

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“…On the other hand, members who revealed less regular hand cleanliness rehearses were likewise at a higher gamble of creating OCD, showing a requirement for adjusted hand cleanliness proposals considering contamination control and skin health (Coman et al, 2015). The seriousness of OCD fluctuated among members, with gentle cases being the most pervasive.…”

Section: Discussionmentioning

confidence: 99%

The Risk of Occupational Contact Dermatitis in Covid-19 Isolation Ward Setting

MUSHTAQ,

JAMIL,

AWAN

et al. 2023

Biol Clin Sci Res J

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Occupational contact dermatitis (OCD) is a prevalent skin condition affecting healthcare workers, particularly those in high-risk environments such as COVID-19 isolation wards. This study aims to summarize the findings of a study conducted on patients to explore the risk factors associated with OCD development among healthcare professionals in COVID-19 isolation ward settings. This prospective observational study aimed to assess the risk of occupational contact dermatitis (OCD) among healthcare professionals working in the COVID-19 isolation ward setting. The study was conducted at Chaudhary Mohammad Akram Hospital for six months, from November 2021 to April 2022. Data was collected from 150 participants of both genders. The participants ranged from 22 to 55 years, with a mean age of 32.5 ± 6.8 years. The study population consisted of 55% females and 45% males. The occupation distribution included doctors (40%), nurses (50%), and support staff (10%). Clinical evaluations revealed that 38 healthcare professionals (25.3%) exhibited signs consistent with occupational contact dermatitis. Among them, 18 participants (47.4%) were diagnosed with irritant contact dermatitis (ICD), while 20 participants (52.6%) showed signs indicative of allergic contact dermatitis (ACD). It is concluded that this study highlights the significant prevalence of occupational contact dermatitis among healthcare professionals in COVID-19 isolation wards. Prolonged PPE usage and frequent hand hygiene practices contribute to skin irritation.

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“…This health disease is a global concern because it has no cure but can only be managed in affected individuals by preventing them from further exposure to these allergens. [1][2][3][4][5][6][7][8][9][10] Some of these xenobiotics are naturally occurring while others are synthetic substances which are present in the environment such as in air due to pollution, [11][12][13][14] plants, [2,11,[15][16][17][18][19] soil [19][20][21] and groundwater. [19] Naphtho-, phenanthrene-and anthraquinones are known to be present in the environment especially in some plants and they play an active role in the pigmentation of plants.…”

Section: Introductionmentioning

confidence: 99%

“…There are several xenobiotics in the environment and thousands of these xenobiotics have been identified as skin allergens that can induce allergic contact dermatitis (ACD), an occupational and environmental health disease. This health disease is a global concern because it has no cure but can only be managed in affected individuals by preventing them from further exposure to these allergens [1–10] . Some of these xenobiotics are naturally occurring while others are synthetic substances which are present in the environment such as in air due to pollution, [11–14] plants, [2,11, 15–19] soil [19–21] and groundwater [19] …”

Section: Introductionmentioning

confidence: 99%

Understanding the Role of pH in Protein‐Haptenation Reaction: Kinetics and Mechanisms of the Protein‐Haptenation Reactions of Selected Quinones Present in the Environment

Olusegun

Martincigh

2020

ChemistrySelect

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There are several xenobiotics (allergens) in the environment which may induce allergic contact dermatitis (ACD), an occupational and environmental health disease. This health disease is of global concern because it has no cure and can only be managed in affected individuals by preventing them from further exposure to these allergens. The following quinones (Q) are known to be air pollutants: 1,2‐naphthoquinone (1,2‐NQ), 1,4‐naphthoquinone (1,4‐NQ), 9,10‐phenanthraquinone (PQ), and 9,10‐anthraquinone (AQ). There have been studies on the cytotoxicity of these air pollutants, but no kinetic studies have been carried out on them to determine their chemical reactivity and, more especially, their interaction with model proteins so as to ascertain if they can react with skin proteins thereby causing allergic reactions. This article provides details on the kinetics studies carried out on the protein‐haptenation reactions of these quinones with 4‐nitrobenzenethiol (NBT), a model nucleophile, as well as the mechanisms of their reactions. The NBT−Q reactions were investigated under pseudo‐first‐order conditions at various concentration ratios at a temperature of 25 °C at three different pH values by either ultraviolet‐visible (UV‐Vis) or stopped‐flow spectrophotometry, as appropriate. The reaction rate constants obtained for the NBT−Q reactions were in the following order: at pH 7.42: 1,2‐NQ>1,4‐NQ>PQ>AQ while at pH 5.65, the order was observed to be 1,2‐NQ>1,4‐NQ>PQ>AQ and at pH 8.41, it was 1,4‐NQ>PQ>AQ>1,2‐NQ. These trends for the reaction rate constants of the Q at the three pH values can be attributed to inductive effects and the position of oxo‐groups on the phenyl rings. The NBT−Q reactions were further investigated by determining the effect of ionic strength on the reaction rate constants with potassium sulphate as the background electrolyte. Our findings showed that there are no charged species at the transition state of the NBT−Q reactions. The products of the NBT−Q reactions were isolated and characterized by means of UV‐Vis and FTIR spectrophotometry and NMR and TOF‐MS spectrometry. The deduced mechanisms for the NBT−Q reactions were validated by computer simulation with “Simkine3” software.

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Occupational Contact Dermatitis

Cited by 16 publications

References 17 publications

Analysis of Prevalence and Risk Factors of Contact Sensitization with respect to the Occupational Profiles in a Greek Patient Cohort: A Retrospective Analysis of a Greek Referral Centre and Future Perspectives

Analysis of Prevalence and Risk Factors of Contact Sensitization with respect to the Occupational Profiles in a Greek Patient Cohort: A Retrospective Analysis of a Greek Referral Centre and Future Perspectives

The Risk of Occupational Contact Dermatitis in Covid-19 Isolation Ward Setting

Understanding the Role of pH in Protein‐Haptenation Reaction: Kinetics and Mechanisms of the Protein‐Haptenation Reactions of Selected Quinones Present in the Environment

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