Occupational dermatoses in a metalworking plant

Gruvberger, Birgitta; Isaksson, Marléne; Frick, Malin; Pontén, Ann; Bruze, M.

doi:10.1034/j.1600-0536.2003.480205.x

Cited by 49 publications

(43 citation statements)

References 15 publications

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“…Chemicals used in tanneries alter the structure of animal hide and therefore may have a damaging effect on the function and the structure to the worker’s skin. We did not find large differences between the results of our cross-sectional survey on OSD with a high risk for OSD in Western countries (Gruvberger et al 2003; Flyvholm et al 2005; Attwa and el-Laithy 2009; Skudlik et al 2009). However, in the observed tanneries, many typical hazardous situations were seen.…”

Section: Discussioncontrasting

confidence: 52%

Inventory of the chemicals and the exposure of the workers’ skin to these at two leather factories in Indonesia

Febriana

Jungbauer

Soebono

et al. 2011

Int Arch Occup Environ Health

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PurposeTannery workers are exposed to hazardous chemicals. Tannery work is outsourced to newly industrialized countries (NICs) where attention into occupational health hazards is limited. In this study, we investigated the skin exposure to hazardous chemicals in tannery workers and determined the prevalence of occupational skin diseases (OSDs) at tanneries in a NIC.MethodsA cross-sectional study on the observation of the working process and an inventory and risk assessment of the chemicals used. Classification of chemicals as potential sensitizers/irritants and a qualitative assessment of exposure to these chemicals. Workers were examined and interviewed using Nordic Occupational Skin Questionnaire-2002/LONG.ResultsThe risk of OSDs at the investigated tanneries was mainly related to the exposure of the workers’ skin to chemicals in hot and humid environmental conditions. In 472 workers, 12% reported a current OSD and 9% reported a history of OSD. In 10% of all cases, an OSD was confirmed by a dermatologist and 7.4% had an occupational contact dermatitis (OCD). We observed that personal protective equipment (PPE) used was mainly because of skin problems in the past and not as a primary protection against OSD.ConclusionWe observed a high frequency and prolonged exposure to many skin hazardous factors in tannery work although PPE was relatively easily available and which was generally used as a secondary preventative measure. The observed point-prevalence in this study was at the same level as that reported for other high-risk OSDs in Western countries and other tanneries in NICs. However, the observed point-prevalence in this study was lower than that reported in India and Korea. The results of our study and those of other studies at tanneries from other NICs were probably influenced by Healthy Worker Survivor Effect (HWSE).

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Section: Discussioncontrasting

confidence: 52%

Inventory of the chemicals and the exposure of the workers’ skin to these at two leather factories in Indonesia

Febriana

Jungbauer

Soebono

et al. 2011

Int Arch Occup Environ Health

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“…Occupational dermatitis was diagnosed in 14% of metal workers in one industry in Sweden, and when considering skin manifestations in general, 55% showed signs [65]. Similar numbers are seen in Finland with 27% reporting skin disease [66].…”

Section: Occupational Exposure To Metalworking Fluidssupporting

confidence: 53%

Upper Airway Mucosal Inflammation : Proteomic Studies after Exposure to Irritants and Microbial Agents

Fornander¹

2015

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People are, in their daily lives, exposed to a number of airborne foreign compounds that do not normally affect the body. However, depending on the nature of these compounds, dose and duration of exposure, various airway symptoms may arise. Early symptoms are often manifested as upper airway mucosal inflammation which generates changes in protein composition in the airway lining fluid.This thesis aims at identifying, understanding mechanisms and characterizing protein alterations in the upper airway mucosa that can be used as potential new biomarkers for inflammation in the mucosa. The protein composition in the mucosa was studied by sampling of nasal lavage fluid that was further analyzed with a proteomic approach using two-dimensional gel electrophoresis and mass spectrometry. Additionally, by studying factors on site through environmental examination, health questionnaires and biological analyses, we have tried to understand the background to these protein alterations and their impact on health.Respiratory symptoms from the upper airways are common among people who are exposed to irritative and microbial agents. This thesis have focused on personnel in swimming pool facilities exposed to trichloramine, metal industry workers exposed to metalworking fluids, employees working in damp and moldy buildings and infants diagnosed with respiratory syncytial virus infection. The common denominator in these four studies is that the subjects experience upper airway mucosal inflammation, which is manifested as cough, rhinitis, phlegm etc. In the three occupational studies, the symptoms were work related. Notably, a high prevalence of perceived mucosal symptoms was shown despite the relatively low levels of airborne irritants revealed by the environmental examination. Protein profiling verified an ongoing inflammatory response by identification of several proteins that displayed altered levels. Interestingly, innate immune proteins dominated and four protein alterations occurred in most of the studies; SPLUNC1, protein S100A8 and S100A9 and alpha-1-antitrypsin. Similarly, these proteins were also found in nasal fluid from children with virus infection and in addition a truncated form of SPLUNC1 and two other S100 proteins (S100A7-like 2 and S100A16), not previously found in nasal secretion, were identified.Altogether, the results indicate the potential use of a proteomic approach for identifying new biomarkers for the upper respiratory tract at an early stage in the disease process after exposure to irritant and microbial agents. The results indicate an effect on the innate immunity system and the proteins; SPLUNC1, protein S100A8 and S100A9 and alpha-1-antitrypsin are especially promising new biomarkers. Moreover, further studies of these proteins may help us to understand the molecular mechanisms involved in irritant-induced airway inflammation. POPULÄRVETENSKAPLIG SAMMANFATTNING FÖRÄNDRAD PROTEINSAMMANSÄTTNING I DE ÖVRE LUFTVÄGARNA EFTER EXPONERING FÖR SLEMHINNEIRRITERANDE ÄMNENVarje dag utsätts vi för partikla...

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“…Occupational hand dermatitis is common in metal workers exposed to wb MWF (Berndt et al 2000;de Boer et al 1989a, b;Funke et al 2001;Grattan et al 1989;Gruvberger et al 2003;Pryce et al 1989a, b). In several studies, the prevalence or 3 year incidence of hand eczema in MWF exposed metal workers was found to be 20-25% (Berndt et al 2000, de Boer et al 1989aFunke et al 2001).…”

Section: Introductionmentioning

confidence: 96%

Contact sensitizations in metalworkers with occupational dermatitis exposed to water-based metalworking fluids: results of the research project ?FaSt?

Geier

Lessmann

Schnuch

et al. 2004

Int Arch Occup Environ Health

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Occupational dermatoses in a metalworking plant

Cited by 49 publications

References 15 publications

Inventory of the chemicals and the exposure of the workers’ skin to these at two leather factories in Indonesia

Inventory of the chemicals and the exposure of the workers’ skin to these at two leather factories in Indonesia

Upper Airway Mucosal Inflammation : Proteomic Studies after Exposure to Irritants and Microbial Agents

Contact sensitizations in metalworkers with occupational dermatitis exposed to water-based metalworking fluids: results of the research project ?FaSt?

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