Occupational exposure and DNA strand breakage of workers in bottom ash recovery and fly ash treatment plants

Chen, Hsiu-Ling; Chen, I-Ju; Chia, Tai-Pao

doi:10.1016/j.jhazmat.2009.09.010

Cited by 17 publications

(10 citation statements)

References 26 publications

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“…Many studies have reported an increase of DNA damage is related to hazardous exposure of municipal waste incinerators. Higher tail moment value was found in workers at fly ash treatment plants (7.55) than in the workers in bottom ash plants (2.64), as well as those in blue collar was higher than in white collar workers (5.72 vs. 3.95) [39]. The lead (Pb) exposure associated oxidative stress was also studied.…”

Section: Field Studies With Workersmentioning

confidence: 98%

Oxidative DNA damages by chemical exposures at work

Rim¹

2012

ABB

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ABSTRACTdiseases. These include cancer, Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, Schizophrenia, bipolar disorder, fragile X syndrome, sickle cell disease and chronic fatigue syndrome. Oxidative stress is likely to be involved in agerelated development of cancer. The reactive species produced in oxidative stress can cause direct damage to the DNA and are therefore mutagenic, and it may also suppress apoptosis and promote proliferation, invasiveness and metastasis [1].Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Of the molecules subject to oxidative modification, DNA has received the greatest attention, with biomarkers of exposure and effect closest to validation. There are many chemicals in workplaces that could cause oxidative DNA damages such as carcinogens. This review concentrated on studies published between the years 2000 and 2012 that used to detect 8-oxodG in humans (workers), laboratory animals and in cell lines. Given the recent toxicological results from oxidative stress, it is important to review these studies to improve the current understanding of the oxidative DNA damages by chemical exposures at work. It also suggests that biomarkers may be responsible for understanding the role of oxidative DNA damage in disease, highlighting the need for further studies.

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Section: Field Studies With Workersmentioning

confidence: 98%

Oxidative DNA damages by chemical exposures at work

Rim¹

2012

ABB

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“…One researcher found that when compared to bottom ash workers, workers in the fly ash treatment plant had significantly higher plasma malondialdehyde [20]. Another researcher found that fly ash treatment plant workers had more DNA damage when compared to their bottom ash counterparts [21]. Although a few occupational health studies have been conducted, epidemiologic studies investigating the impact coal ash has on the surrounding community are limited [22,23].…”

Section: Introductionmentioning

confidence: 99%

Respiratory Health in Adults Residing Near a Coal-Burning Power Plant with Coal Ash Storage Facilities: A Cross-Sectional Epidemiological Study

Hagemeyer

Sears

Zierold

2019

IJERPH

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Coal ash, the byproduct of burning coal made up of small particles, including heavy metals and radioactive elements, is discarded in open-air landfills where it can be emitted into the air, contributing to air pollution in the surrounding community. Few regulations exist regarding the storage, disposal, and transport of coal ash. There is limited research on the health impacts of coal ash exposure on communities. The purpose of this study was to examine the prevalence of respiratory symptoms among adults exposed to coal ash and non-exposed adults. A cross-sectional epidemiological study was conducted among two populations: one exposed to coal ash and one not exposed to coal ash. Perception of health (p-Value < 0.0001), cough (Adjusted Odds Ratio (AOR) = 5.30, 95% Confidence Intervals (CI) = 2.60–11), shortness of breath (AOR = 2.59, 95% CI = 1.56–4.31), hoarseness (AOR = 4.02, 95% CI = 2.45–6.60), respiratory infections (AOR = 1.82, 95% CI = 1.14–2.89), and mean overall respiratory health score (p-Value < 0.0001) were all statistically significantly greater in exposed adults (N = 231) when compared to non-exposed adults (N = 170). Adults residing near the coal ash facility were more likely to report respiratory symptoms than the non-exposed population. More research on the health impact of coal ash and storage regulations needs to be conducted.

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“…Workers handling fly ash were also found to have increased markers of oxidative stress and DNA damage compared to workers in bottom ash plants (Liu, Shih, Chen, & Chen, 2008;Chen, Chen, & Chia, 2010). Animal studies have shown that coal ash particles can affect lung epithelial cells, neutrophils, and macrophages (Goldsmith et al, 1999;Smith, Veranth, Kodavanti, Aust, & Pinkerton, 2006), and immune effects were found after exposing human lymphocytes to 16 trace elements commonly found in fly ash (Shifrine, Fisher, & Taylor, 1984).…”

Section: Coal Ash and Human Healthmentioning

confidence: 99%

Memory and fine motor skill test performance among children living near coal ash storage sites.

Tompkins¹

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Occupational exposure and DNA strand breakage of workers in bottom ash recovery and fly ash treatment plants

Cited by 17 publications

References 26 publications

Oxidative DNA damages by chemical exposures at work

Oxidative DNA damages by chemical exposures at work

Respiratory Health in Adults Residing Near a Coal-Burning Power Plant with Coal Ash Storage Facilities: A Cross-Sectional Epidemiological Study

Memory and fine motor skill test performance among children living near coal ash storage sites.

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