Occupational exposure to anaesthetics in 20 hospitals

Davenport, Harold T.; Halsey, Michael J.; Wardley‐Smith, Bridget; Bateman, P. E.

doi:10.1111/j.1365-2044.1980.tb05116.x

Cited by 66 publications

(14 citation statements)

References 7 publications

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“…The frequencies of chromosomal aberrations encountered in control populations from the literature indicates that exchange-type aberrations vary between 7 and 12 in 10 000 metaphases, with an average of 7.6 exchange events in lo4 cells. The frequency of breaks is much higher and varies from 14 to 100 x cells.z3 Our analysis of chromosome aberrations represents data obtained from 100 metaphases/ individual, so this is probably why it was not possible to detect the reported low baseline frequency of other types of aberrations in the control population.…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic damage in operation theatre personnel

Natarajan

Santhiya

1990

Anaesthesia

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The study in a group of 24 (11 anaesthetists and 13 support staff) was planned to ascertain the cytogenetic risk in a group of theatre personnel who worked in various city hospitals. Their exposure in terms of duration of service vary from 3-30 years. The control group (n = 24) consisted of people with different occupations matched for possible confounding variables. Cytogenetic risk was assessed in terms of chromosome aberration and sister chromatid exchange in 72-hour lymphocyte cultures. A significant increase in the percentage of chromosome aberration was observed. The sister chromatid exchange was double that of the baseline value in 20% of the exposed individuals. These findings indicate the possible risk of cytogenetic damage for staff working in unscavenged rooms.

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Section: Discussionmentioning

confidence: 99%

Cytogenetic damage in operation theatre personnel

Natarajan

Santhiya

1990

Anaesthesia

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“…Studies have shown that a reduction of anaesthetic gas exposure of the operating personnel during mask induction would be absolutely essential to reduce MAK-values (Maximale Arbeitsplatzkonzentration, tolerated critical limits for inhalational anaesthetics in the operating room) to established recommended limits (NIOSH 1977). According to Davenport there is little correlation between room air turnover rate in the operating room and the occupational exposure to inhalational anaesthetics (Davenport et al 1980). Perthes first described a funnel-shaped scavenging system placed near the head of the patient with a flow of 1600 m3.h-' (Perthes 1925).…”

Section: Discussionmentioning

confidence: 99%

Exposure of operating personnel to inhalational anaesthetics in paediatric surgery

Weber¹

1994

Pediatric Anesthesia

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High flows of halothane and N20 are commonly used in children during induction of anaesthesia. We prospectively evaluated the efficiency of a double mask system in children, during inhalational induction with photoacoustic infrared spectroscopy. Thirtytwo children 5 days to 8.5 years of age were studied. Anaesthesia was induced with inspired halothane concentrations of 2-3% and N20 50-70% in 6-8 litres of freshgas flow via a Jackson-Rees breathing system. Children were randomly assigned into two groups. Anaesthesia was induced in group 1 using a Rendell-Baker mask with a regular scavenging device (25 l.min-'). In group 11 a double-mask system was connected to an active scavenging system (580 1 min-'). Halothane and N20 were measured at 10 cm below the chin of the anaesthesiologist. We could demonstrate that the use of double-mask system with a regular scavenging device substantially reduced the exposure of the anaesthesiologist to halothane by 89% and to N20 80% respectively during inhalational induction.

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“…This anaesthetic may cause mild liver damage in human patients but around 1 in 30 000 develops severe liver damage due to reactive metabolites combining with liver proteins which then elicit an autoimmune response (Neuberger & Williams, 1988;Bird & Williams, 1992). In human medical practice, occupational exposure to halothane and other medical gases has long been recognised as a health issue and efforts have been made to monitor and reduce this (Linde & Bruce, 1969;Cohen et al, 1975;Hunter, 1976;Whitcher & Piziali, 1977;Korttila et al, 1978;Davenport et al, 1980;Kole, 1990;Henderson & Matthews, 2000;Sitarek et al, 2000;Byhahn et al, 2001). There have been reports of adverse effects including neurotoxicity, hepatotoxicity and spontaneous abortion among anaesthetists and other exposed medical workers (Belfrage et al, 1966;Klatskin & Kimberg, 1969;Grimmeisen, 1973;Corbett et al, 1974;Popova et al, 1980;Duvaldestin et al, 1981;Neuberger et al, 1981;Keiding et al, 1984;Lings, 1988;Franco, 1989;Luchini et al, 1996).…”

Section: Anaestheticsmentioning

confidence: 99%

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Woodward¹

2005

Vet Pharm & Therapeutics

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Although seemingly rare, adverse reactions to veterinary products do occur. These may arise from inadvertent exposure during use or as a result of occupational accidents. They are often mild in nature and include adverse effects such as minor skin reactions. However, more serious reactions may occur, and they are not restricted to the effects of the veterinary medicines themselves. For example, high-pressure injection injuries may occur as a result of accidents occurring during animal vaccination operations. This paper reviews some of these events, mentions where appropriate the regulatory actions taken, and describes some of the measures used to minimise such effects in the future, and serves to bring the issues discussed here to the attention of pharmacologists, pharmacoepidemiologists and others who train those who use veterinary medicinal products.

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Occupational exposure to anaesthetics in 20 hospitals

Cited by 66 publications

References 7 publications

Cytogenetic damage in operation theatre personnel

Cytogenetic damage in operation theatre personnel

Exposure of operating personnel to inhalational anaesthetics in paediatric surgery

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

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