Occupational exposure to anesthetics leads to genomic instability, cytotoxicity and proliferative changes

Souza, Kátina M.; Braz, Leandro Gobbo; Nogueira, Flávia R.; Souza, Maria Aparecida Miranda de; Bincoleto, Lahis Fernandes; Aun, Aline G.; Corrente, José Eduardo; Carvalho, Lídia Raquel de; Bráz, José Reinaldo Cerqueira; Braz, Mariana Gobbo

doi:10.1016/j.mrfmmm.2016.09.002

Cited by 60 publications

(55 citation statements)

References 40 publications

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“…Consistent with these results, we also previously observed that anesthesiologists working in the same studied hospital who were chronically exposed (average of 16 years) to waste anesthetic gases had a significantly higher buccal MN frequency (2.3-fold) compared to unexposed physicians. 35 Another study 36 also reported elevated buccal MN frequency (2.6-fold) in operating room personnel after chronic exposure to older (enflurane and halothane) and modern (isoflurane, sevoflurane, and desflurane) halogenated anesthetics together with nitrous oxide. Therefore, the slightly increased MN frequency observed in the studied medical residents might result in genomic instability over time.…”

Section: F I G U R Ementioning

confidence: 96%

High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross‐sectional study

et al. 2020

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This cross-sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency.Concentrations of waste anesthetic gases were measured in the operating rooms to assess anesthetic pollution. The exposed group comprised individuals occupationally exposed to inhalational anesthetics, while the control group comprised individuals without anesthetic exposure. We quantified DNA damage; genetic instability (micronucleus-MN); protein, lipid, and DNA oxidation; antioxidant activities; and proinflammatory cytokine levels. Trace concentrations of anesthetics (isoflurane: 5.3 ± 2.5 ppm, sevoflurane: 9.7 ± 5.9 ppm, and nitrous oxide: 180 ± 150 ppm) were above international recommended thresholds. Basal DNA damage and IL-17A were significantly higher in the exposed group [27 ± 20 a.u. and 20.7(19.1;31.8) pg/mL, respectively] compared to the control group [17 ± 11 a.u. and 19.0(18.9;19.5) pg/mL, respectively], and MN frequency was slightly increased in the exposed physicians (2.3-fold). No significant difference was observed regarding oxidative stress biomarkers. The findings highlight the genetic and inflammatory risks in young physicians exposed to inhalational agents in operating rooms lacking adequate scavenging systems. This potential health hazard can accompany these subjects throughout their professional lives and reinforces the need to reduce ambient air pollution and consequently, occupational exposure. K E Y W O R D S genomic instability, indoor air pollution, inflammation, inhalation anesthetics, oxidative stress, work environment | 513 BRAZ et Al.

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Section: F I G U R Ementioning

confidence: 96%

High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross‐sectional study

et al. 2020

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“…As far as we know, to date, only one study has evaluated genomic instability, cell death and proliferative index in exfoliated buccal cells of anaesthesiologists who had chronic exposure and those of non-anaesthesiologist physicians who were not exposed to anaesthetics (21). The authors concluded that exposure to modern waste anaesthetic gases did not induce systemic DNA damage, but it did result in genomic instability, cytotoxicity and proliferative changes, which were detected in exfoliated buccal cells of anaesthesiologists.…”

Section: Discussionmentioning

confidence: 99%

Can Sevoflurane Induce Micronuclei Formation in Nasal Epithelial Cells of Adult Patients?

Kesimci¹,

Coşkun²,

Uğur³

et al. 2017

Turk J Anaesth Reanim

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“…Although several studies proved patient safety of VA application, occupational exposure to anaesthetic agents has been a cause for concern among ICU staff . Inconsistent threshold limit concentrations for ISO, SEVO, and DES between countries and poor air‐conditioning in ICUs compared to operating rooms amplify the problem.…”

Section: Introductionmentioning

confidence: 99%

Environmental safety: Air pollution while using MIRUS™ for short‐term sedation in the ICU

Herzog-Niescery

Vogelsang

Gude

et al. 2018

Acta Anaesthesiol Scand

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Occupational exposure to anesthetics leads to genomic instability, cytotoxicity and proliferative changes

Cited by 60 publications

References 40 publications

High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross‐sectional study

High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross‐sectional study

Can Sevoflurane Induce Micronuclei Formation in Nasal Epithelial Cells of Adult Patients?

Environmental safety: Air pollution while using MIRUS™ for short‐term sedation in the ICU

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