2018
DOI: 10.1136/oemed-2018-105058
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Occupational exposure to benzene, toluene, xylene and styrene and risk of prostate cancer in a population-based study

Abstract: Exposure to any BTX was associated with higher risks of overall PCa. Prolonged exposures at the substantial level to benzene and styrene increased risks of low-grade tumours. These novel findings were independent from PCa screening.

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Cited by 43 publications
(41 citation statements)
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“…While our analysis took into account a number of health behaviors, residual confounding or lack of adjustment for factors not yet recognized in PCa development cannot be ruled out. Disadvantageous SEP during adulthood may be linked to occupational features associated with PCa such as shift work ( 59 ) and exposure to chemical agents ( 33 , 60 ). Further adjustment for these factors did not alter findings (data not shown).…”
Section: Discussionmentioning
confidence: 99%
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“…While our analysis took into account a number of health behaviors, residual confounding or lack of adjustment for factors not yet recognized in PCa development cannot be ruled out. Disadvantageous SEP during adulthood may be linked to occupational features associated with PCa such as shift work ( 59 ) and exposure to chemical agents ( 33 , 60 ). Further adjustment for these factors did not alter findings (data not shown).…”
Section: Discussionmentioning
confidence: 99%
“…We conducted a sensitivity analysis excluding proxy respondents, who might be less cognizant of subjects' exposures, and observed no difference in results. Nevertheless, occupational circumstances are a specific focus of the PROtEuS study and our team has considerable experience in eliciting detailed work histories and in assigning occupational titles ( 33 , 61 ). Moreover, reports of work histories have been shown to be valid ( 62 ).…”
Section: Discussionmentioning
confidence: 99%
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“…The PROtEuS population has been described in detail previously [19, 20]. Briefly, eligible subjects were men aged ≤ 75 years at diagnosis or recruitment, Canadian citizens and residing in the greater Montreal area.…”
Section: Methodsmentioning
confidence: 99%
“…Besides the occupational cohort studies, there are other studies that evaluated styrene and cancer, including cohort and nested case-control studies of workers in various industries in which styrene was not a main exposure of interest (Budroni et al 2010;Guénel et al 2002;Marsh et al 2001;Radican et al 2008); population-and hospitalbased case-control studies that evaluated the relation between occupational exposure to styrene and other agents and various cancers (Blanc-Lapierre, Sauve, and Parent 2018;Cantor et al 1995;Gérin et al 1998;Cocco et al 2010;Costantini et al 2008;Dumas et al 2000;Flodin et al 1986;Karami et al 2011;Miligi et al 2006;Scélo et al 2004;Seidler et al 2007;Siemiatycki 1991); a prospective cohort study of environmental exposure to styrene and other hazardous outdoor air pollutants and the risk of invasive breast cancer (Garcia et al 2015); and ecologic studies that investigated environmental exposure to styrene and cancer (Bulka et al 2016;Coyle et al 2005). These study types are less informative than the occupational cohort studies given generally lower number of subjects and imprecise exposure information.…”
Section: Strainmentioning
confidence: 99%