Occupational exposure to chemical substances and time to pregnancy: a systematic review

Snijder, Claudia A.; Velde, Egbert te; Roeleveld, Nel; Burdorf, Alex

doi:10.1093/humupd/dms005

Cited by 76 publications

(58 citation statements)

References 90 publications

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“…Duration and intensity of solvent exposure, which are determining for their impact on reproductive function, were not assessed in our study. Moreover, despite the large number of studies focusing on solvent exposure, there is a lack of evidence about their specific effects on male fertility (39). This is mainly due to substantial heterogeneity between these studies with regard to exposure characterization, the study population, and the choice of the measurement of fertility.…”

Section: Discussionmentioning

confidence: 99%

Routine assessment of occupational exposure and its relation to semen quality in infertile men: a cross-sectional study

et al. 2017

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Background/aim: Concerns about the detrimental effects of occupational and environmental exposure on male reproductive function have been raised by reports of declining sperm quality over the last decades. The aim of this study was to investigate the association between altered semen parameters and exposure to occupational risk factors as assessed by questionnaire. Materials and methods:We conducted a cross-sectional questionnaire-based study among a population of 2122 men who underwent andrological investigation for couple infertility. All participants were interviewed and their semen samples were analyzed. Information about medical history and occupational exposure was used to classify participants into exposed and unexposed groups.Results: Exposure to pesticides was associated with a significantly higher risk of asthenozoospermia (adjusted odds ratio [OR] = 1.6; 95% CI, 1.0-2.4) and necrozoospermia (OR = 2.6; 95% CI, 1.4-4.7). Exposure to cement was found to be correlated with a higher risk of oligozoospermia (OR = 1.1; 95% CI, 0.9-1.4). There was no association between semen impairment and exposure to solvents, excess heat, or mechanical vibrations. Conclusion:We found an association between self-reported occupational exposure and altered semen parameters. These results support the usefulness of questionnaires for routine assessment and management of occupational exposures in infertile men.

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Section: Discussionmentioning

confidence: 99%

Routine assessment of occupational exposure and its relation to semen quality in infertile men: a cross-sectional study

et al. 2017

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“…Although there are yet no conclusive certainties about this phenomenon during the years, different factors have been proposed to be involved in the accumulation of risk factors for infertility and for male infertility. These factors could be either related to social changes as well as to lifestyle [47,48], such as smoke of tobacco [49][50][51] and marijuana [52][53][54], alcohol [55,56], medications [57] and caffeine [58], but also to the environmental pollution, such as pesticides, solvents [59,60], electromagnetic fields (EMFs) [61][62][63] and compounds able to interfere with the endocrine control of biological functions.…”

Section: Gscs Spermatozoa and Endocrine Disruptorsmentioning

confidence: 99%

Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling

Bernabò¹,

Ramal-Sanchez²,

Valbonetti³

et al. 2018

Germ Cell

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The study of germline stem cells and of germline cells has deep implications for the understanding of fertility, development and cancer. Nowadays, we are experiencing the very fascinating challenge of application of -OMICS technologies to this issue, which is opening new and unexpected horizons in virtually all the branches of biology. Here, we carried out a review of signalling systems involved in maturation of male germ cells and in the process that leads them to become fully fertile. In particular, we discuss the control mechanisms involved in capacitation and acrosome reaction that act at membrane level. Indeed, spermatozoa membranes play key roles in determining the achievement of fertility: they are the interface with the surrounding environment, they locate the signal transduction systems and they are active in recognizing and binding the oocyte. In addition, we discuss the effect of several compounds that could exert a negative effect on reproductive activity, by interfering with the endocrine axis, the so-called endocrine disruptors.

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“…Пестицидтердің репродуктивті жүйеге әсеріне қатысты көптеген зерттеулер, көбінесе ересек кезеңде жағымсыз әсерін зерттеу бойынша, сонымен қатар антенаталды кезеңде, балалық шақ кезеңінде, азырақ жеткіншектік кезеңде жүргізілген [42][43][44][45][46].…”

Section: кіріспеunclassified

Effect of pesticides on human health

2017

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Occupational exposure to chemical substances and time to pregnancy: a systematic review

Abstract: Despite some uncertainties in the evidence base, it may still be prudent to advise against lead and pesticide exposure at the workplace for couples trying to conceive. This review also identifies several priorities for future studies in the field of occupational epidemiology.

Cited by 76 publications

References 90 publications

Routine assessment of occupational exposure and its relation to semen quality in infertile men: a cross-sectional study

Routine assessment of occupational exposure and its relation to semen quality in infertile men: a cross-sectional study

Membrane Dynamics of Spermatozoa during Capacitation: New Insight in Germ Cells Signalling

Effect of pesticides on human health

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