Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France

Barul, Christine; Fayossé, Aurore; Carton, Matthieu; Pilorget, Corinne; Woronoff, Anne‐Sophie; Stücker, Isabelle; Luce, Danièle

doi:10.1186/s12940-017-0286-5

Cited by 35 publications

(37 citation statements)

References 32 publications

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“…UADT cancers are an increasingly relevant public health issue, as they rank in the top six malignancies worldwide [ 6 ]. Epidemiological evidence indicates various factors being related to an increased risk of developing these cancers, including viral infections, poor oral hygiene, occupation (e.g., exposure to certain chemicals), diet, alcohol consumption, and tobacco smoking [ 1 , 6 , 7 , 8 ]. However, alcohol consumption and tobacco smoking are the factors that show the strongest association.…”

Section: Introductionmentioning

confidence: 99%

Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity

Stornetta

Guidolin

Balbo

2018

Cancers

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Alcohol is classified by the International Agency for Research on Cancer (IARC) as a human carcinogen and its consumption has been associated to an increased risk of liver, breast, colorectum, and upper aerodigestive tract (UADT) cancers. Its mechanisms of carcinogenicity remain unclear and various hypotheses have been formulated depending on the target organ considered. In the case of UADT cancers, alcohol’s major metabolite acetaldehyde seems to play a crucial role. Acetaldehyde reacts with DNA inducing modifications, which, if not repaired, can result in mutations and lead to cancer development. Despite alcohol being mainly metabolized in the liver, several studies performed in humans found higher levels of acetaldehyde in saliva compared to those found in blood immediately after alcohol consumption. These results suggest that alcohol-derived acetaldehyde exposure may occur in the oral cavity independently from liver metabolism. This hypothesis is supported by our recent results showing the presence of acetaldehyde-related DNA modifications in oral cells of monkeys and humans exposed to alcohol, overall suggesting that the alcohol metabolism in the oral cavity is an independent cancer risk factor. This review article will focus on illustrating the factors modulating alcohol-derived acetaldehyde exposure and effects in the oral cavity.

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Section: Introductionmentioning

confidence: 99%

Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity

Stornetta

Guidolin

Balbo

2018

Cancers

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“…In addition, in most studies, cancers of the oral cavity were grouped with oropharyngeal cancers, or even all pharyngeal cancers, and oropharyngeal cancers have never been studied separately, despite distinct etiological factors. We previously investigated the role of exposure to chlorinated solvents in head and neck cancer risk (4), and found no evidence of an association between these solvents and oral or oropharyngeal cancer. Here, we aimed to examine whether occupational exposure to petroleum-based and oxygenated solvents is associated with oral and oropharyngeal cancer risk in men.…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to petroleum-based and oxygenated solvents and oral and oropharyngeal cancer risk in men: A population-based case-control study in France

Barul

Carton

Radoï

et al. 2019

Cancer Epidemiology

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Objective: To examine the association between occupational exposure to petroleumbased and oxygenated solvents and the risk of oral and oropharyngeal cancer. Methods: The ICARE study is a large population-based case-control study conducted in France between 2001 and 2007. This present analysis was restricted to men and included 350 and 543 cases of squamous cell-carcinoma of the oral cavity and oropharynx, respectively, and 2,780 controls. Lifetime tobacco, alcohol consumption and complete occupational history were assessed through detailed questionnaires. Job-exposure matrices allowed us to assess occupational exposure to five petroleum-based solvents (white spirits; diesel/fuel oils/kerosene; gasoline; benzene; special petroleum products) and five oxygenated solvents (diethyl ether; tetrahydrofuran; ketones and esters; alcohols; ethylene glycol). Odds-ratios (ORs), adjusted for age, smoking, alcohol consumption and socioeconomic status, and 95% confidence intervals (CI) were estimated using unconditional logistic models. Results: Associations between oral cancer risk and exposure to white spirits and diesel/fuel oils/kerosene were suggested, but there was no exposure-response trend. Concerning exposure to oxygenated solvents, participants with the highest levels of cumulative exposure to diethyl ether had a significant excess risk of oropharyngeal cancer (OR=7.78, 95%CI 1.42; 42.59; p for trend=0.04). Ever exposure to tetrahydrofuran was associated with a borderline significant increased risk of oral cancer (OR=1.87, 95%CI 0.97; 3.61), but no exposure-response trend was observed. Additional adjustments for exposure to other solvents did not substantially change the results. 3 Conclusion: Our results do not provide evidence for a major role of petroleumbased and oxygenated solvents in the occurrence of oral and oropharyngeal cancers in men.

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“…Exposure indices were provided for different calendar periods to take into account variations due to changes in exposure over time. Specific JEMs were also used to assess exposure to asbestos [ 17 ] and perchloroethylene [ 10 ]. Exposure to strong inorganic acids was obtained for each job from specific questions in the questionnaire.…”

Section: Methodsmentioning

confidence: 99%

“…We previously examined the role of chlorinated solvents in head and neck cancer risk, and found an association between exposure to perchloroethylene and laryngeal cancer [ 10 ]. In our study population, increased risks of laryngeal and/or hypopharyngeal cancer were also observed among building caretakers, cleaners, farm workers, toolmakers, rubber and plastic workers, who may be exposed to other types of solvents [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

et al. 2018

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BackgroundTo examine associations between occupational exposure to petroleum-based and oxygenated solvents and the risk of hypopharyngeal and laryngeal cancer.MethodsICARE is a large, frequency-matched population-based case-control study conducted in France. Lifetime occupational history, tobacco smoking and alcohol consumption were collected. Analyses were restricted to men and included 383 cases of hypopharyngeal cancer, 454 cases of laryngeal cancer, and 2780 controls. Job–exposure matrices were used to assess exposure to five petroleum-based solvents (benzene; gasoline; white spirits; diesel, fuels and kerosene; special petroleum products) and to five oxygenated solvents (alcohols; ketones and esters; ethylene glycol; diethyl ether; tetrahydrofuran). Odds ratios (ORs) adjusted for smoking, alcohol drinking and other potential confounders and 95% confidence intervals (CI) were estimated with unconditional logistic models.ResultsNo significant association was found between hypopharyngeal or laryngeal cancer risk and exposure to the solvents under study. Non-significantly elevated risks of hypopharyngeal cancer were found in men exposed to high cumulative levels of white spirits (OR = 1.46; 95% CI: 0.88–2.43) and tetrahydrofuran (OR = 2.63; 95CI%: 0.55–12.65), with some indication of a dose-response relationship (p for trend: 0.09 and 0.07 respectively).ConclusionThis study provides weak evidence for an association between hypopharyngeal cancer and exposure to white spirits and tetrahydrofuran, and overall does not suggest a substantial role of exposure to petroleum-based or oxygenated solvents in hypopharyngeal or laryngeal cancer risk.Electronic supplementary materialThe online version of this article (10.1186/s12885-018-4324-7) contains supplementary material, which is available to authorized users.

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Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France

Cited by 35 publications

References 32 publications

Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity

Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity

Occupational exposure to petroleum-based and oxygenated solvents and oral and oropharyngeal cancer risk in men: A population-based case-control study in France

Occupational exposure to petroleum-based and oxygenated solvents and hypopharyngeal and laryngeal cancer in France: the ICARE study

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