Occupational exposure to epoxy resins has no cytogenetic effect

Mitelman, Felix; Fregert, Sigfrid; Hedner, Karin; Hillbertz-Nilsson, Kerstin

doi:10.1016/0165-1218(80)90006-3

Cited by 26 publications

(6 citation statements)

References 5 publications

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“…In some cases, these studies have correlated well with the carcinogenicity of solvents, as assessed by epidemiologic methods [Purchase et al, 1978;Fredga et al, 1979Fredga et al, , 1982Sorsa et al, 1983;Maki-Paakkanen et al, 19841. Other studies have produced conflicting data, indicating that some of these exposures may not be genotoxic [Haglund et al, 1980;Mitelman et al, 1980;Suskov and Sazonova, 1982;Sazonova and Suskov, 19851. Therefore, the current study of IBPAT members was initiated to investigate further the genotoxicity of the complex solvent exposures encountered by members of this trade.…”

Section: Introductionmentioning

confidence: 95%

Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters

Kelsey

Wiencke

Little

et al. 1988

Environ and Mol Mutagen

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A cross-sectional study of sister chromatid exchange frequency (SCE) in peripheral blood lymphocytes from 117 members of the International Brotherhood of Painters and Allied Tradesman was conducted in union locals in two major U.S. cities. Chronic solvent exposure intensity and duration were estimated from interviewer-administered-questionnaire data. SCE for all of the workers in the study were scored by one reader. A second reader determined the SCE frequency from a random sample of 30 workers. No significant difference in SCE frequency was associated with reader or time of reading. Age, coffee and alcohol intake and chronic solvent exposure (both intensity and duration, estimated over the working lifetime and over the year prior to study for each worker) did not significantly elevate SCE. The effect of smoking on SCE frequency, assessed by analysis of variance controlling for other possible confounding factors, showed that smoking increased SCE frequency (P less than .0001). The SCE frequency in the smoking, solvent-exposed (estimated as lifetime exposure) painters was 6.75 SCE/cell; in the non-smoking, solvent-exposed workers the SCE frequency was 5.73 SCE/cell; the controls had SCE levels of 6.84 SCE/cell (smokers) and 5.90 SCE/cell (non-smokers), respectively. These observations are consistent with other work suggesting that chronic solvent exposure in the paint trade is not associated with an elevation in SCE in peripheral blood lymphocytes. However, further work is necessary to address adequately the question of the genotoxicity of acute solvent exposure in these workers.

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Section: Introductionmentioning

confidence: 95%

Effects of cigarette smoking and solvent exposure on sister chromatid exchange frequency in painters

Kelsey

Wiencke

Little

et al. 1988

Environ and Mol Mutagen

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“…The first is all0 isothiocyanate (oil of mustard), incorporated into the product only for its irritating effect on mucous membranes, without any known systemic carcinogenic effect. The second is polystyrene, a nonvolatile component that has never been shown to cause any cytogenetic abnormalities [3]. The third component is toluene, which is contaminated with less than 1% of benzene.…”

Section: Introductionmentioning

confidence: 99%

Acute nonlymphocytic leukemia in a glue sniffer

et al. 1985

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A 17-year-old white male with a past history of chronic inhalational abuse of plastic glue was referred to our institution for sore throat, cervical adenopathy, and an abnormal peripheral blood smear. A diagnosis of acute myelomonocytic leukemia was made and abnormalities in cytogenetic studies were demonstrated. Specific inquiry regarding this form of drug exposure should be pursued when searching for possible etiologies of malignant disease.

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“…for humans exposed to epoxy resins are inconclusive. Suskov & Sazonova (8) found a significant increase in chromosome aberrations in workers exposed to epoxy resins, while Mitelman et a1 (9) did not find any significant difference between exposed worlcers and referents.…”

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confidence: 98%