Occupational Exposure to Ionizing Radiation and Risk of Breast Cancer in Western Australia

Buitenhuis, Wenny; Fritschi, Lin; Thomson, Allyson; Glass, Deborah Catherine; Heyworth, Jane; Peters, Susan

doi:10.1097/jom.0b013e3182a7e692

Cited by 14 publications

(11 citation statements)

References 34 publications

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“…IR can cause DNA damage, both directly by causing breaks in the DNA strands and indirectly by interacting with water molecules and generating reactive oxygen species that damage DNA (Buitenhuis et al, 2013; Nations and Scientific Committee, 2008; World Cancer Research Fund/American Institute for Cancer Research, 2007). DNA damage with loss of cellular senescence checkpoints and immortalization allows a cell to grow indefinitely and to go through further oncogenic steps, which can result in carcinoma (Buitenhuis et al, 2013; Dimri et al, 2005; World Cancer Research Fund/American Institute for Cancer Research, 2007). Moreover, IR induces the formation of acentric chromosome fragments and, to a small extent, malsegregation of whole chromosomes (International Atomic Energy Agency, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, IR induces the formation of acentric chromosome fragments and, to a small extent, malsegregation of whole chromosomes (International Atomic Energy Agency, 2011). Acentric chromosome fragments and whole chromosomes that are unable to connect with the spindle lag behind at anaphase and are not included in the main daughter nuclei (Buitenhuis et al, 2013; Fenech et al, 2011; International Atomic Energy Agency, 2011). A lagging chromosome fragment, or whole chromosome, forms into a small separate nucleus called a micronucleus (MN) (International Atomic Energy Agency, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Genotoxic risk in health-care professionals occupationally exposed to low doses of ionizing radiation

et al. 2020

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The purpose of this study was to evaluate the potential influence of occupational ionizing radiation (IR) exposure on health professionals, assessing DNA damage using the comet and micronucleus (MN) assays and analyzing relative risks, correlations, and associated factors between outcomes and socioeconomic and lifestyle factors. Blood and buccal samples were collected from 36 workers, who actively participated in an imaging sector of a hospital, who were either exposed to IR directly or indirectly (9 internal control and 27 exposed), and 27 individuals living in the same city but with no occupational exposure (external control, unexposed/healthy). All radiation dosages performed on the 36 workers were less than 20 mSv/y, not exceeding the effective dose limit for occupational exposure. A questionnaire identified socioeconomic and lifestyle factors associated with the outcomes. The results of the MN assay showed a significant difference between both internal control and the exposed group when compared to the external control. For the comet assay, there were significant differences between the percent of tail DNA of the exposed group and external controls, but no difference was found between the exposed group and internal controls. Relative risk associations were found in time of exposure, hours worked per week, and perceived stress. Correlations were found between the outcomes and age, consumption of alcohol, and frequencies of X-rays during life. Variables that showed to be significant in the adjusted analysis were skin color and recent exposure to radiation. Albeit limited, the findings of this study suggest genotoxicity in both blood and buccal mucosa cells of workers exposed directly or indirectly to IR and that lifestyle and socioeconomic factors are associated and correlated with the risk of developing these outcomes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genotoxic risk in health-care professionals occupationally exposed to low doses of ionizing radiation

et al. 2020

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“…The standing X-ray, which spinal surgeons use to plan surgery, is considered the gold standard for measuring spinal alignment [9]. However, repeated doses of ionizing radiation increases the risk of health problems, such as an altered immune response and increased cancer risk [5,10]. Although improvements in radiographic technology have minimized radiation exposure, long-term health complications remain problematic [11,12].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Sagittal Spinal Alignment on Standing Plain X-Rays and Supine MRI in Degenerative Lumbar Disease

Wang¹,

Bai²,

Pan³

et al. 2020

Preprint

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Background:The purpose of present study is to examine the possible correlation between standing plain X-rays and supine MRI for evaluating spinal sagittal alignment in degenerative lumbar disease.Methods: The characteristics and images of 64 patients with degenerative lumbar diseases were reviewed retrospectively. The thoracolumbar junction kyphosis (TJK), lumbar lordosis (LL), and sacral slope (SS) were measured on lateral plain X-rays and by magnetic resonance imaging (MRI). Inter- and intra-observer reliability were tested using intra-class correlation coefficients. Results: The results suggested that TJK measurements obtained from MRI tended to underestimate the radiographic measures by 2°, whereas SS measurements obtained from MRI tended to overestimate the radiographic measures by 2°. The LL measurements obtained from MRI were approximately equal to the radiographic measures. The X-ray and MRI measurements were linearly related. Conclusions:In conclusion, supine MRI can be directly translated into sagittal alignment angle measurements obtained from standing X-rays with an acceptable degree of accuracy. This can avoid the impaired view caused by the overlapping ilium, while reducing the patient’s exposure to radiation.

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“…In Western Australia at current levels of occupational exposure to ionizing radiation the risk of breast cancer was found to be low (OR = 1.16; 95% CI 0.86-1.57), although the risk of human epidermal growth factor receptor 2-positive cancer may be a concern (OR = 2.57; 95% CI 1.09-6.03) [263]. The female orthopaedic surgeons had a statistically significant 2.9-fold higher prevalence of breast cancer compared to the general U.S. female population (standardized prevalence ratio: 2.9; 95% CI 1.66-4.71) [264].…”

Section: Ionizing Radiationmentioning

confidence: 95%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

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Breast cancer is the most frequent cancer in women. It is believed that among the causes of breast cancer, hereditary factors account for only 5-10% of risk and the environmental exposures to environmental contaminants account for an additional 30-50% of risk. This paper summarizes findings related to the risk of breast cancer due to exposure to following environmental contaminants: polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins, organochlorine pesticides, organophosphorous pesticides, bisphenol A, phthalates, parabens, organic solvents, atmospheric pollutants, alkylphenols, metals, ionizing radiation, electromagnetic field and light pollution. Results obtained in in vitro experiments with breast cancer cell lines and in vivo with model rodents as well as in population based case-control studies are presented and the mode of action of individual environmental contaminants on mammary gland is discussed. Attention is also devoted to the effects of the timing of exposure to environmental contaminants (mainly exposition during development of the mammary gland) on breast cancer risk. Outcomes of professional exposure to some environmental contaminants on breast cancer risk are analysed as well.

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Occupational Exposure to Ionizing Radiation and Risk of Breast Cancer in Western Australia

Abstract: This study suggests that the risk of breast cancer is low at current levels of occupational exposure to ionizing radiation, although the risk of human epidermal growth factor receptor 2-positive cancer may be a concern.

Cited by 14 publications

References 34 publications

Genotoxic risk in health-care professionals occupationally exposed to low doses of ionizing radiation

Genotoxic risk in health-care professionals occupationally exposed to low doses of ionizing radiation

Comparison of Sagittal Spinal Alignment on Standing Plain X-Rays and Supine MRI in Degenerative Lumbar Disease

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

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