Occupational Exposure to Lead and Induction of Genetic Damage

Abstract

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Elevated blood lead levels and cytogenetic markers in buccal epithelial cells of painters in India

“…They observed that frequency of chromosomal aberrations and sister chromatid exchanges increased significantly with the Table 1 Summary (mean±SD) of Pb-B (μg/dl) and frequencies (counts per 3,000 cells) of micronuclei and nuclear changes in buccal epithelial cells of control and exposed subjects rise of lead concentrations in urine, showing a linear correlation. (Vaglenov et al 2001) had found genotoxic effect of lead by the MNT. Investigations of lead exposure in outdoor painters revealed high level of CA and SCE in lymphocytes and elevated MN in buccal cells (Pinto et al 2000).…”

Individual susceptibility and genotoxicity in workers exposed to hazardous materials like lead

“…In this study, a significant increase in the frequency of chromosomal aberrations, satellite associations, DNA damage and micronuclei in the buccal epithelial cells was observed in exposed subjects as compared to control individuals. In earlier reports, an increased incidence of micronuclei in peripheral lymphocytes was observed in a group of 22 lead workers whose mean BLL was 61 g/dl relative to control groups with mean BLLs of 18-28 g/dl [31,32]. Battery plant workers (n = 37) had significantly elevated levels of DNA breaks in lymphocytes compared to unexposed subjects (n = 29) [30].…”

Increased Lipid Peroxidation and Ascorbic Acid Utilization in Testis and Epididymis of Rats Chronically Exposed to Lead

“…Lead is a toxic element for human and animal organisms (Adonaylo & Oteiza 1999;Ye et al 1999;Vaglenov et al 2001). Its negative impact on reproduction is well known (Thoreux-Manlay et al 1995;Alexander et al 1996;Gandley et al 1999).…”