Occupational Exposure to Paints Causes Impairment of Kidney Functions

Al‐Ghamdi, Saeed S.

doi:10.4236/jep.2011.25061

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…An occupational disease is any chronic ailment that occurs as a result of work or occupational activity. It is an aspect of occupational safety and health, typically identified when the disease is more prevalent in a given group of workers compared with the general population or with other groups of workers [1] [2]. The assessment of occupational diseases therefore provides models for understanding environmental diseases.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Renal Biomarkers of Renal Function in Commercial Automobile Workers in Benin City, Edo State, Nigeria

Adejumo¹,

Awelogun²,

Uchuno³

et al. 2018

OJNeph

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Background: Blood-urea nitrogen, creatinine, uric acid and electrolytes are important biomarkers of renal function which could be considered as suitable prognostic indicators of renal dysfunction. Aim: The aim of this work was to assess renal biomarkers of renal function in commercial automobile workers in Benin City, Edo State, Nigeria. Methodology: A total of 158 males within the ages of 18-60 years participated in this study, 50 of which are control subjects. They were recruited for this study from various workshops in Benin City, while controls are unexposed volunteers. Results: It was observed that serum uric acid, urea, creatinine, chloride and bicarbonate levels in all the exposed groups were significantly higher (p < 0.05 or p < 0.01 or p < 0.001) compared with the non-exposed group. Apart from blood urea, the values of all the other biomarkers of renal function fell within normal reference range. However, there were no significant differences in all the renal biomarkers when compared among all the exposed groups. Conclusion: This study indicated greater levels of some renal biomarkers in automobile workers compared with the controls. In addition, blood urea levels were elevated above normal range of values. These findings suggest that the occupationally exposed automobile workers may be at risk of renal diseases. This calls for urgent need for policy formulation that will prevent the vulnerable groups from kidney damage.

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Section: Introductionmentioning

confidence: 99%

Assessment of Renal Biomarkers of Renal Function in Commercial Automobile Workers in Benin City, Edo State, Nigeria

Adejumo¹,

Awelogun²,

Uchuno³

et al. 2018

OJNeph

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“…Patients with renal impairments may have increased oxidant activity and a reduced antioxidant capacity, and this is increased in a graded manner with increasing renal dysfunction [25]. A study on painters who had worked for more than ten years supported the hypothesized association between solvent exposure and the development of chronic renal failure [26]. However, another study of a small group of male metal degreasers in Sweden observed no increase in NAG excretion into the urine, concluding that TCE was not nephrotoxic at low exposure levels [27].…”

Section: Discussionmentioning

confidence: 97%

Urinary Malondialdehyde (MDA) and N-Acetyl-β-D-Glucosaminidase (NAG) Associated with Exposure to Trichloroethylene (TCE) in Underground Water

Lin

Kuo

et al. 2022

Toxics

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Trichloroethylene (TCE) is commonly used in various industries. If wastewater in factories is not effectively treated, the inflow into and subsequent contamination of underground water is likely. Our study assessed the association of exposure to TCE in underground water with oxidative stress and renal tubule damage. We selected 579 residents from areas with underground water contaminated with TCE. Each participant was interviewed via a questionnaire. We also assessed their urinary trichloroacetic acid (TCA) levels by gas chromatography (GC)-FID. Urinary malondialdehyde (MDA) and N-acetyl-β-D-glucosaminidase (NAG) were taken as indicators of oxidative stress and renal tubule damage. We found about 73% of the residents to have consumed underground water. The average duration of consumption was 26 years, with an average of 1.6 L per day. Currently, only 1.5% of the residents still continuously consume underground water. The consumption of underground water positively correlated with heightened urinary TCA levels (r = 0.554). Heightened urinary TCA levels, in turn, were positively associated with NAG levels (r = 0.180) but negatively associated with MDA levels (r = −0.193). The results held even after we had segmented urinary TCA levels into three groups of different levels. The elimination of the source of heightened TCE levels from various industrial effluents is essential. Residents exposed to TCE-laden underground water should periodically undergo health inspections.

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“…These substances have been shown to have demonstrable nephrotoxic, 4 hepatotoxic 5 and hematotoxic 6 effects similar to the results of the present study. Accordingly, Al-Ghamdi, 7 studied the kidney function of car painters who had prolonged exposure to paint fumes and found a significant higher mean serum value of Cr, Ur and UA than levels in the unexposed groups.…”

Section: Discussionmentioning

confidence: 99%

“…Reactive metabolites from paints and other solvents can also cause physiochemical damage to the glomerular membrane and tubules due to their high lipophilicity. 7 Such damage has been shown to alter the functional integrity of the membrane, impairs Na + /K + /ATPase activity and several other enzymes involved in ionic and acid-base balance. Also, associated tubular damage can cause tubular dysfunction, impairs renal excretory function, macula densa cell signaling mechanisms, renal hemo-dynamics/autoregulation and poor handling of metabolic waste products with a resultant increase in serum Cr, Ur and UA as observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Changes in Estimated Glomerular Filtration Rate, Biochemical and Hematological Profile of Workers in Spray Painting Industry: A Cross-Sectional Study

Ekpenyong¹,

Nkereuwem²

2019

Nephrol Open J

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There is a global increase in occupational exposure to solvents, some of which are suspected to cause acute or chronic toxic nephropathies in humans. However, limited studies have been done to evaluate the systemic effects of exposure to some of the commonly used solvents such as paints. Aim The aim of the present study was to assess the effect of chronic exposure to paint fumes on renal and hepatic functions of industrial spray painters. Methodology In this cross-sectional study, 49 occupationally exposed male industrial spray painters who had served for greater than 5 years were evaluated for changes in renal, hepatic and hematological indices using standard instruments and results were compared with levels in the unexposed (sex and age-matched) participants. Results Significant changes in markers of renal, hepatic and hematological functions were observed in the exposed compared with unexposed participants including significant decrease in estimated glomerular filtration rate (eGFR) and serum levels of potassium (K +) and chloride (Cl-), and significant increases in serum levels of creatinine (Cr), sodium (Na +), urea (Ur) and uric acid (UA) in the exposed compared to levels in the unexposed group. Abnormal serum levels of hepatic enzymes (AST, ALT and ALP) and hematological indices (PCV, total-RBC, nuetrophils, basophils, monocytes and lymphocytes) were also observed in the exposed compared to levels in the unexposed participants. Conclusion Prolonged exposure to paint fumes may be associated with a significant risk for hepato-renal dysfunction and hematotoxicity. Preventive measures should include limiting exposure and using antioxidant medications.

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Occupational Exposure to Paints Causes Impairment of Kidney Functions

Abstract: ABSTRACT

Cited by 7 publications

References 22 publications

Assessment of Renal Biomarkers of Renal Function in Commercial Automobile Workers in Benin City, Edo State, Nigeria

Assessment of Renal Biomarkers of Renal Function in Commercial Automobile Workers in Benin City, Edo State, Nigeria

Urinary Malondialdehyde (MDA) and N-Acetyl-β-D-Glucosaminidase (NAG) Associated with Exposure to Trichloroethylene (TCE) in Underground Water

Changes in Estimated Glomerular Filtration Rate, Biochemical and Hematological Profile of Workers in Spray Painting Industry: A Cross-Sectional Study

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