Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case–control studies

Merhi, Maysaloun; Raynal, H; Cahuzac, Eric; Vinson, Florence; Cravedi, Jean Pierre; Gamet-Payrastre, Laurence

doi:10.1007/s10552-007-9061-1

Cited by 159 publications

(102 citation statements)

References 83 publications

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“…When observations were limited to those individuals with more than 10 years of exposure, the risk increased (OR, 1.65; 95% CI, 1.08-1.95). 125 While the meta-analysis supports the hypothesis that pesticides are associated with NHL, they lack sufficient detail about pesticide exposure and other information on risk factors for hematopoietic cancers to identify specific causes. 125 Since the publication of the meta-analysis by Merhi et al, 125 several new population-based studies have been published suggesting that specific pesticides play an important role in NHL etiology.…”

Section: Prostate Cancermentioning

confidence: 94%

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Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

296

213

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A growing number of well-designed epidemiological and molecular studies provide substantial evidence that the pesticides used in agricultural, commercial, and home and garden applications are associated with excess cancer risk. This risk is associated both with those applying the pesticide and, under some conditions, those who are simply bystanders to the application. In this article, the epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non-Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated. Although the review is not exhaustive in its scope or depth, the literature does strongly suggest that the public health problem is real. If we are to avoid the introduction of harmful chemicals into the environment in the future, the integrated efforts of molecular biology, pesticide toxicology, and epidemiology are needed to help identify the human carcinogens and thereby improve our understanding of human carcinogenicity and reduce cancer risk. CA Cancer J Clin 2013;63:120-142.

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Section: Prostate Cancermentioning

confidence: 94%

“…For working on a farm for more than 10 years, the OR was 1.87 (95% CI, 1.15-3.16). 125 None of these studies, however, was able to identify a specific exposure that was associated with multiple myeloma. In the AHS, an excess risk of multiple myeloma was observed in the cohort.…”

mentioning

confidence: 99%

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

296

213

View full text Add to dashboard Cite

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“…Chronic exposure to pesticides indicates the risk of hematopoietic malignancies (Dennis, 1993;Hoshizaki et al, 1969;Loge, 1965;Merhi et al, 2007;Parent-Massin & Thouvenot, 1993;Vial et al, 1996) and might lead to the onset of different pathologies. Possible risk of hematological disorders such as leukemia, multiple myeloma, Hodgkin lymphoma, and nonHodgkin lymphoma were explored (Merhi et al, 2007;Rudant et al, 2007) in agriculture workers, farmers, or employees in chemical industries. A cross-sectional study in cut-flower farmers indicated the hematotoxic effects due to pesticide exposure (Del Prado-Lu, 2007).…”

Section: Introductionmentioning

confidence: 99%

In vitromyelotoxic effects of cypermethrin and mancozeb on human hematopoietic progenitor cells

Mandarapu

Prakhya

2014

Journal of Immunotoxicology

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In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition to routine toxicity evaluation. Currently, the data available on effects of pesticides on hematopoiesis in humans is limited. In the study here, cypermethrin and mancozeb were evaluated for their possible effects on hematopoiesis in vitro. Hematopoietic stem or progenitor cells from human cord blood were isolated and then exposed for 14 days to cypermethrin or mancozeb at noncytotoxic doses (0.9-16 mM), and the effect on hematopoiesis screened via a methylcellulosebased clonogenic assay. Results indicated there were significant concentration-related decreases in clonogenic potentials of erythroid and granulocyte-macrophage colony formation. respectively. These data suggest that erythroid progenitors are perhaps more sensitive to these pesticides. Still, further studies are needed to understand the functional significance of these in vitro findings. For now, these data, albeit preliminary, emphasize the need to include an expanded battery of tests to understand effects on immune parameters in pre-clinical safety studies with pesticides. This study also emphasizes the utility of human cord blood in assessing potential effects on hematopoiesis in vitro.

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“…More recent systematic review studies or case-control studies reported positive association between exposure to pesticides and several cancers including prostate cancer (Van Maele-Fabry and Willems, 2004;Koutros et al, 2010;Doolan G et al, 2014), non-Hodgkin lymphoma (NHL) (Merhi et al, 2007;Balasubramaniam et al, 2013;Yildirim et al, 2013;Schinasi and Leon, 2014), leukemia (Merhi et al, 2007;Van Maele-Fabry et al, 2008), multiple myeloma (Merhi et al, 2007) and lung cancer (Ganesh et al, 2011;Luqman et al, 2014). In the case of esophageal or gastric cancer, no relationship with pesticide usage was reported in recent Turkey study (Yildirim et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Critical Review on the Carcinogenic Potential of Pesticides Used in Korea

Choi

2014

Asian Pacific Journal of Cancer Prevention

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Pesticides used in Korea are grouped by four classes of hazard (extremely, highly, moderately and slightly hazardous) based on acute oral and dermal toxicity in the rat. However, there is little information of carcinogenic effects. The aim of this study was to evaluate potential carcinogenicity for active ingredients of pesticides used in Korea. A total of 1,283 pesticide items were registered under the Pesticide Control Act of which 987 were commercially available. Of these 987 items, 360 active ingredients not duplicated were evaluated for carcinogenicity using the carcinogen list established by the US Environmental Protection Agency (EPA). Some 25 out of 360 ingredients were classified as likely to be carcinogenic (probable) to humans and 52 had suggestive evidence of carcinogenic potential (suspected) based on the US EPA classification. Some 31% of 987 items contained probable or suspected human carcinogenic ingredients. Carcinogenic pesticides accounted for 24% (5,856/24,795 tons) of the total volume of consumption in Korea. Interestingly, pesticides with lower acute toxicity were found to have higher carcinogenic potential. Based on these findings, the study suggests that it is important to provide information on long-term toxicity to farmers, in addition to acute toxicity data.

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Occupational exposure to pesticides and risk of hematopoietic cancers: meta-analysis of case–control studies

Cited by 159 publications

References 83 publications

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Increased cancer burden among pesticide applicators and others due to pesticide exposure

In vitromyelotoxic effects of cypermethrin and mancozeb on human hematopoietic progenitor cells

Critical Review on the Carcinogenic Potential of Pesticides Used in Korea

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