Occupational exposure to pesticides, reproductive hormone levels and sperm quality in young Brazilian men

Cremonese, Cleber; Piccoli, Camila; Pasqualotto, Fábio Firmbach; Clapauch, Ruth; Koifman, Rosalina Jorge; Koifman, Sérgio; Freire, Carmen

doi:10.1016/j.reprotox.2017.01.001

Cited by 85 publications

(34 citation statements)

References 43 publications

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“…Agricultural populations in developing countries are exposed to increasing amounts of pesticides mixtures, at high concentrations and frequency, including pesticides severely restricted and banned in industrialized countries 21 . We have previously reported associations of cumulative exposure to pesticides, especially herbicides and dithiocarbamate fungicides, with hypothyroidism-like effects and poorer sperm quality in male farm workers in Serra Gaúcha, a family-based agricultural region in the South of Brazil 22,23 . Based on the hypothesis that both persistent and non-persistent pesticides may have the ability to cause hematological disorders in humans, we sought to assess the relationship of agricultural work practices, use of non-persistent pesticides, and serum levels of OC pesticides with hematological parameters in farm residents in this region.…”

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confidence: 99%

Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil

Piccoli

Cremonese

Koifman

et al. 2019

Ciênc. saúde coletiva

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This study sought to investigate the association of exposure to organochlorine (OC) and non-persistent pesticides with hematological parameters in an agricultural population in Southern Brazil. A cross-sectional study was conducted with a random sample of 275 farm workers and their families in Farroupilha-RS. A questionnaire was used to collect information on sociodemographic and lifestyle factors, duration, frequency and type of pesticide used, among others. Blood samples were collected and analyzed for serum concentration of 24 OC pesticides and hematological parameters. Associations were explored through linear regression, controlling for confounders. Lifetime use of chemical classes other than organophosphates and dithiocarbamates were associated with decreased number of lymphocytes, while subjects sampled in the high pesticide use season showed higher number of erythrocytes and hemoglobin level. Detectable serum levels of many OC pesticides were associated with lower counts of white blood cells, particularly eosinophils. Although mostly null associations were observed between pesticide use and hematological parameters, findings may suggest that OC pesticides could lead to hematological alterations among agricultural workers.

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confidence: 99%

Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil

Piccoli

Cremonese

Koifman

et al. 2019

Ciênc. saúde coletiva

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“…The association of occupational exposure to current-use pesticides with reproductive hormones, semen quality, and genital measures was investigated among young men. It supposed that chronic occupational exposure to modern pesticides might affect reproductive outcomes in this group [32].…”

Section: Resultsmentioning

confidence: 99%

Reproductive Toxic Chemicals at Work and Efforts to Protect Workers' Health: A Literature Review

Rim

2017

Safety and Health at Work

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A huge number of chemicals are produced and used in the world, and some of them can have negative effects on the reproductive health of workers. To date, most chemicals and work environments have not been studied for their potential to have damaging effects on the workers' reproductive system. Because of the lack of information, many workers may not be aware that such problems can be related to occupational exposures. Newly industrialized countries such as Republic of Korea have rapidly amassed chemicals and other toxicants that pose health hazards, especially to the reproductive systems of workers. This literature review provides an overview of peer-reviewed literature regarding the teratogenic impact and need for safe handling of chemicals. Literature searches were performed using PubMed, Google Scholar, and ScienceDirect. Search strategies were narrowed based on author expertise and 100 articles were chosen for detailed analysis. A total of 47 articles met prespecified inclusion criteria. The majority of papers contained studies that were descriptive in nature with respect to the Medical Subject Headings (MeSH) terms and keywords: “reproductive and heath or hazard and/or workplace or workers or occupations.” In the absence of complete information about the safe occupational handling of chemicals in Republic of Korea (other than a material safety data sheet), this review serves as a valuable reference for identifying and remedying potential gaps in relevant regulations. The review also proposes other public health actions including hazard surveillance and primary prevention activities such as reduction, substitution, ventilation, as well as protective equipment.

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“…In recent years, the deleterious effect of environmental toxins on mitochondrial function has been studied extensively in humans (Eldakroory et al, 2016, Cremonese et al, 2017, Hongsibsong et al, 2017, Sittitoon et al, 2017) and model organisms such as rodents (O’Brien and Wallace, 2004, Suzuki et al, 2008, Butenhoff et al, 2009, Butenhoff et al, 2012), fish (Ge et al, 2017), zebrafish (Bestman et al, 2015, Liu et al, 2015, Jia et al, 2016, Chen et al, 2016, Raftery et al, 2017), Caenorhabditis elegans ( C. elegans ) (Zhou et al, 2013, Liu et al, 2015, Wyatt et al, 2017), and cellular models (Zieminska et al, 2016, D’Mello et al, 2017, Yang et al, 2017). A large number of environmental factors including l-methyl-4phenyl-l, 2, 3, 6-tetra-hydropyridine (MPTP), and pesticides such as rotenone and paraquat are now widely-recognized mitochondrial toxins (Backer and Weinstein, 1980, Harmon and Sanborn, 1982, Nicklas et al, 1987, Youngster et al, 1987) and specifically, neurotoxins.…”

Section: Environmental Toxins and Deleterious Effect On Mitochondriamentioning

confidence: 99%

Clinical effects of chemical exposures on mitochondrial function

Zolkipli‐Cunningham

Falk

2017

Toxicology

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Mitochondria are critical for the provision of ATP for cellular energy requirements. Tissue and organ functions are dependent on adequate ATP production, especially when energy demand is high. Mitochondria also play a role in a vast array of important biochemical pathways including apoptosis, generation and detoxification of reactive oxygen species, intracellular calcium regulation, steroid hormone and heme synthesis, and lipid metabolism. The complexity of mitochondrial structure and function facilitates its diverse roles but also enhances its vulnerability. Primary disorders of mitochondrial bioenergetics, or Primary Mitochondrial Diseases (PMD) are due to inherited genetic defects in the nuclear or mitochondrial genomes that result in defective oxidative phosphorylation capacity and cellular energy production. Secondary mitochondrial dysfunction is observed in a wide range of diseases such as Alzheimer’s and Parkinson’s disease. Several lines of evidence suggest that environmental exposures cause substantial mitochondrial dysfunction. Whereby literature from experimental and human studies on exposures associated with Alzheimer’s and Parkinson’s diseases exist, the significance of exposures as potential triggers in Primary Mitochondrial Disease (PMD) is an emerging clinical question that has not been systematically studied.

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Occupational exposure to pesticides, reproductive hormone levels and sperm quality in young Brazilian men

Cited by 85 publications

References 43 publications

Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil

Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil

Reproductive Toxic Chemicals at Work and Efforts to Protect Workers' Health: A Literature Review

Clinical effects of chemical exposures on mitochondrial function

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