Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study

Too, Chun Lai; Muhamad, Nor Asiah; Ilar, Anna; Padyukov, Leonid; Alfredsson, Lars; Klareskog, Lars; Murad, Shahnaz; Bengtsson, Camilla

doi:10.1136/annrheumdis-2015-208278

Cited by 87 publications

(62 citation statements)

References 42 publications

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“…Finally, other inhaled irritants such as silica, air pollution, and textile dust may also increase the risk for RA, particularly seropositive RA [42–46]. While the epidemiology of these environmental factors is less developed compared to smoking, the associations of these other environmental factors emphasize that the lung, and potentially other mucosal sites, may provide the common link and micro-environment important for a variety of biologic processes that ultimately present clinically as RA.…”

Section: Cigarette Smoking and Transitions Between Preclinical Phasesmentioning

confidence: 99%

The Roles of Cigarette Smoking and the Lung in the Transitions Between Phases of Preclinical Rheumatoid Arthritis

Sparks

Karlson

2016

Curr Rheumatol Rep

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While the etiology of rheumatoid arthritis (RA) remains to be fully elucidated, recent research has advanced the understanding of RA pathogenesis to the point where clinical trials for RA prevention are underway. The current paradigm for RA pathogenesis is that individuals progress through distinct preclinical stages prior to the onset of clinically apparent RA. These preclinical RA phases consist of genetic risk, local inflammation, presence of RA-related autoantibodies, asymptomatic systemic inflammation, and early non-specific symptoms prior to clinical seropositive RA. Epidemiologic studies have been important in forming hypotheses related to the biology occurring in preclinical RA. Specifically, studies associating cigarette smoking with overall RA risk as well as transitions between phases of preclinical RA were vital in helping to establish the lung as a potential important initiating site in the pathogenesis of seropositive RA. Herein, we review the epidemiology associating smoking with transitions in preclinical phases of RA as well as the recent literature supporting the lung as a critical site in RA pathogenesis.

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Section: Cigarette Smoking and Transitions Between Preclinical Phasesmentioning

confidence: 99%

The Roles of Cigarette Smoking and the Lung in the Transitions Between Phases of Preclinical Rheumatoid Arthritis

Sparks

Karlson

2016

Curr Rheumatol Rep

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“…Occupational inhalant exposures have been increasingly associated with the risk of disease development, particularly among males . Elevated risks of RA have been mainly observed among men who are farmers, mechanics, construction workers, and warehouse workers, in addition to those with occupational exposure to silica . Among women, the link between occupational exposures and RA risk has been less clear .…”

Section: Introductionmentioning

confidence: 99%

“…(17) Elevated risks of RA have been mainly observed among men who are farmers, mechanics, construction workers, and warehouse workers, in addition to those with occupational exposure to silica. (17)(18)(19) Among women, the link between occupational exposures and RA risk has been less clear. (17) These observations support the hypothesis that repetitive inhalation exposure to an inflammatory environmental insult could precipitate and/or potentiate arthritis, particularly in men.…”

Section: Introductionmentioning

confidence: 99%

Combined Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation to Model Inflammatory Lung Disease in Rheumatoid Arthritis

Poole

Thiele

Janike

et al. 2019

Journal of Bone and Mineral Research

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Rheumatoid arthritis (RA) is characterized by extra‐articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. The collagen‐induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone/joint–lung inflammatory outcomes. DBA/1J mice were intranasally treated with saline or ODE daily for 5 weeks. CIA was induced on days 1 and 21. Treatment groups included sham (saline injection/saline inhalation), CIA (CIA/saline), ODE (saline/ODE), and CIA + ODE (CIA/ODE). Arthritis inflammatory scores, bones, bronchoalveolar lavage fluid, lung tissues, and serum were assessed. In DBA/1J male mice, arthritis was increased in CIA + ODE > CIA > ODE versus sham. Micro‐computed tomography (µCT) demonstrated that loss of BMD and volume and deterioration of bone microarchitecture was greatest in CIA + ODE. However, ODE‐induced airway neutrophil influx and inflammatory cytokine/chemokine levels in lavage fluids were increased in ODE > CIA + ODE versus sham. Activated lung CD11c+CD11b+ macrophages were increased in ODE > CIA + ODE > CIA pattern, whereas lung hyaluronan, fibronectin, and amphiregulin levels were greatest in CIA + ODE. Serum autoantibody and inflammatory marker concentrations varied among experimental groups. Compared with male mice, female mice showed less articular and pulmonary disease. The interaction of inhalation‐induced airway inflammation and arthritis induction resulted in compartmentalized responses with the greatest degree of arthritis and bone loss in male mice with combined exposures. Data also support suppression of the lung inflammatory response, but increases in extracellular matrix protein deposition/interstitial disease in the setting of arthritis. This coexposure model could be exploited to better understand and treat RA–lung disease. © 2019 American Society for Bone and Mineral Research.

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“…We have no epidemiological data about dukhan habits in our cohort or in Sudan in general, but it is practiced by almost all married Sudanese women. Thus, we hypothesize that dukhan might be another environmental RA risk factor acting through the lungs in a similar manner to cigarette smoking 38 , silica exposure 44,45 , traffic pollution 46 , or most recently, occupational exposure to textile dust 47 . The low prevalence of autoantibody-positive RA in our Sudanese cohort is, however, an argument against this hypothesis, because the strong association between smoking and RA has been reported to be confined to the ACPA-positive RA subset, at least among whites 38 .…”

Section: Rheumatologymentioning

confidence: 99%

Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden

Elshafie

Elkhalifa²,

Elbagir³

et al. 2016

J Rheumatol

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Objective.To compare clinical characteristics and treatment between simultaneously investigated Sudanese and Swedish outpatients with rheumatoid arthritis (RA).Methods.Outpatients with RA from Sudan (n = 281) and Sweden (n = 542) diagnosed according to the 1987 American College of Rheumatology criteria were recruited between December 2008 and September 2010 and compared concerning clinical presentation, treatment, and laboratory findings, including immunoglobulin M with rheumatoid factor (IgM-RF).Results.Sudanese patients had lower inclusion age (median 49 vs 68 yrs), disease duration (48 vs 107 mos), and disease onset age (43 vs 56 yrs) as compared with Swedish patients (p < 0.0001 for all). When stratified concerning the age of inclusion, Swedish patients between 41–50 years had, however, a significantly lower age of onset, with a similar trend for all age groups above 30 years. The female preponderance was higher among Sudanese patients (89.3% vs 72.5%, p < 0.0001), and smoking was nonexistent among Sudanese female patients (p < 0.0001). Erythrocyte sedimentation rate levels and number of tender joints were significantly higher among Sudanese patients. The proportion of IgM-RF positivity was lower among Sudanese patients with RA (52.4% vs 75.5%, p < 0.0001). Higher proportions of Sudanese patients with RA were treated with methotrexate (MTX) and disease-modifying antirheumatic drug combinations, but none of them used biologics. Sudanese patients used lower doses of MTX and sulfasalazine (p < 0.0001) and higher doses of prednisolone (p < 0.0001) than Swedish patients.Conclusion.Sudanese patients with RA have significantly higher disease activity and are often IgM-RF–seronegative. Together with reports from Uganda and Cameroon, our data indicate a cluster of highly active and often seronegative RA in central Africa.

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Occupational exposure to textile dust increases the risk of rheumatoid arthritis: results from a Malaysian population-based case–control study

Cited by 87 publications

References 42 publications

The Roles of Cigarette Smoking and the Lung in the Transitions Between Phases of Preclinical Rheumatoid Arthritis

The Roles of Cigarette Smoking and the Lung in the Transitions Between Phases of Preclinical Rheumatoid Arthritis

Combined Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation to Model Inflammatory Lung Disease in Rheumatoid Arthritis

Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden

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