Occupational exposure to trichloroethylene and cancer risk for workers at the Paducah Gaseous Diffusion Plant

Bahr, Debra E; Aldrich, Tim E.; Seidu, Dazar; Brion, Gail M.; Tollerud, David J.; Muldoon, Susan B.; Reinhart, Nancy; Youseefagha, Ahmed; McKinney, Paul; Hughes, Therese; Chan, Caroline; Rice, Carol; Brewer, David E.; Freyberg, R.W.; Mohlenkamp, Adriane Moser; Hahn, Kristen; Hornung, Richard; Ho, Mona; Dastidar, Aniruddha; Freitas, Samantha; Saman, Daniel M.; Ravdal, Hege; Scutchfield, F. Douglas

doi:10.2478/s13382-011-0007-1

Cited by 18 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar null results were found in our MM review, now including results from six additional studies not previously evaluated 31 32 36 39 52 58. Our study also found similar results to those of two previous reviews that reported no association between TCE exposure and risk of leukaemia,10 21 but with the inclusion of findings from five additional cohorts 31 36 39 50 52. To our knowledge, our study is the only review to assess CLL/SLL risk in relation to occupational TCE exposure; no significant findings were found.…”

Section: Discussionsupporting

confidence: 90%

“…Our updated meta-analysis, evaluating NHL risk and occupational TCE exposure incorporated three recently published cohort analyses39 50 52 and four case–control studies 59–61 63. Significantly increased risk estimates were seen for cohort studies overall, for those that specifically assessed TCE-exposed workers and for combined cohort and case–control ‘TCE-exposure’ studies.…”

Section: Discussionmentioning

confidence: 99%

“…Our study also included results from two recently published occupational cohort studies not previously assessed in previous reviews 50 52. One of these cohorts, which was categorised as a ‘chlorinated solvent-exposure’ study, did not observe an increase in NHL risk 52.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Occupational trichloroethylene exposure and risk of lymphatic and haematopoietic cancers: a meta-analysis

et al. 2013

View full text Add to dashboard Cite

The carcinogenic potential of trichloroethylene (TCE) continues to generate much controversy, even after the US Environmental Protection Agency raised its classification to 'carcinogenic to humans'. We conducted a meta-analysis of published cohort and case-control studies exploring occupational TCE exposure in relation to five different lymphatic and haematopoietic cancers: non-Hodgkin's lymphoma (NHL, N=24), Hodgkin's lymphoma (HL, N=13), multiple myeloma (MM, N=11), leukaemia (N=12) and chronic/small lymphocytic leukaemia (CLL/SLL, N=7). Studies published between 1950 and 2011 were identified through a PubMed Medline search. All studies included in analyses were classified as those that assessed either occupational TCE exposure specifically ('TCE-exposure' studies) or a broader classification of all chlorinated solvents ('chlorinated solvent-exposure' studies). A significantly raised summary estimate for NHL was seen for all cohort and case-control 'TCE-exposure' studies combined (N=19; relative risk (RR)=1.32, 95% CI 1.14 to 1.54; I(2)=25.20; p-heterogeneity=0.12) and for cohort 'TCE-exposure' studies (N=10; RR=1.52, 95% CI 1.29 to 1.79; I(2)=7.09; p-heterogeneity=0.63). A non-significant but raised summary estimate was seen for NHL case-control 'TCE-exposure' studies. No significant association with NHL risk was detected overall for any 'chlorinated solvent-exposure' studies. Summary estimates for occupational TCE exposure were not associated with risk of HL, MM, leukaemia or CLL/SLL. Our updated meta-analysis of NHL, which incorporates new analytical results from three cohort and four case-control studies, supports an association between occupational TCE exposure and NHL.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Occupational trichloroethylene exposure and risk of lymphatic and haematopoietic cancers: a meta-analysis

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Where these volatile organic compounds (VOCs) were accidentally spilled on the soil during transport or leaked from their storage places, large DNAPL vapour plumes and long-term solute plumes in the groundwater developed. Many recent studies have shown the high toxicity of TCE (Bahr et al 2011;Rusyn et al 2014). Solute plumes may have a serious direct impact on the quality of groundwater and soils.…”

mentioning

confidence: 99%

Evaluation of VOC fluxes at the soil-air interface using different flux chambers and a quasi-analytical approach

Cotel

Schäfer

Traverse³

et al. 2015

Water Air Soil Pollut

View full text Add to dashboard Cite

Dense nonaqueous-phase liquids (DNAPLs) spilled on the soil migrate vertically depending upon gravity and capillary forces through the unsaturated zone of the porous aquifer, forming a vapour plume. These volatile organic compounds (VOCs) can be transferred by advection-diffusion to the groundwater or to the atmosphere. Evaluating DNAPL vapour fluxes at the soil-air interface is one of the key challenges in the remediation of contaminated sites. This work discusses the results of a large-scale vapour plume experiment with a well-defined trichloroethylene (TCE) spill, including a sequential raising and lowering of the water table, where the TCE vapour fluxes at the soil surface were experimentally quantified in two ways: (i) directly, with measurements at the soil-air interface using different flux chambers at various operational modes under both transient and steady-state conditions of the vapour plume, and (ii) indirectly, using a quasi-analytical approach based on soil gas measurements. It was shown that upward displacement of the water-air front during the controlled raising of the water table (approximately 10 cm h −1 ) increased the TCE vapour flux measured at the soil surface by factors of 4 to 10. Under steady-state transport conditions, TCE vapour fluxes measured using five types of flux chambers and three operational modes were similar. The effects of the flux chamber geometry, the accumulation of TCE vapours in the chamber headspace or the air recirculation at a low flow rate on the measured TCE vapour fluxes were low. At steady-state transport conditions, TCE vapour fluxes measured with the flux chambers and estimated using the quasianalytical approach were of the same order of magnitude. However, under transient conditions of the vapour plume, the TCE vapour flux predicted by the quasi-analytical approach greatly underestimated or overestimated the real TCE vapour flux at the soil-air interface.

show abstract

“…The effect on health care workers was a source of bias in occupational epidemiological studies and was recorded (17)(18)(19). The risk was not statistically significant in terms of excess relative risk (ERR) and/or standard mortality ratio (SMR), but there was evidence of increasing cancer mortality risk from exposure to IR (20,21). A number Low-dose ionizing radiation increases the mortality risk of solid cancers in nuclear industry workers: A meta-analysis of complex factors affect the health of nuclear industry workers, their external exposure to radiation and death of the residents (20,22).…”

Section: Introductionmentioning

confidence: 99%

Low-dose ionizing radiation increases the mortality risk of solid cancers in nuclear industry workers: A meta-analysis

Gao

Tang

et al. 2018

mol clin onc

View full text Add to dashboard Cite

Abstract. Low-dose ionizing radiation (LDIR) may increase the mortality of solid cancers in nuclear industry workers, but only few individual cohort studies exist, and the available reports have low statistical power. The aim of the present study was to focus on solid cancer mortality risk from LDIR in the nuclear industry using standard mortality ratios (SMRs) and 95% confidence intervals. A systematic literature search through the PubMed and Embase databases identified 27 studies relevant to this meta-analysis. There was statistical significance for total, solid and lung cancers, with meta-SMR values of 0.88, 0.80, and 0.89, respectively. There was evidence of stochastic effects by IR, but more definitive conclusions require additional analyses using standardized protocols to determine whether LDIR increases the risk of solid cancer-related mortality.

show abstract

Occupational exposure to trichloroethylene and cancer risk for workers at the Paducah Gaseous Diffusion Plant

Cited by 18 publications

References 16 publications

Occupational trichloroethylene exposure and risk of lymphatic and haematopoietic cancers: a meta-analysis

Occupational trichloroethylene exposure and risk of lymphatic and haematopoietic cancers: a meta-analysis

Evaluation of VOC fluxes at the soil-air interface using different flux chambers and a quasi-analytical approach

Low-dose ionizing radiation increases the mortality risk of solid cancers in nuclear industry workers: A meta-analysis

Contact Info

Product

Resources

About