Occupational Exposures and Chronic Obstructive Pulmonary Disease. Causality Established, Time to Focus on Effect and Phenotypes

Martínez, Carlos H.; Delclos, George L.

doi:10.1164/rccm.201501-0106ed

Cited by 4 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In summary, in this multicenter study of current and former smokers in the United States, VGDF exposure in the longest job was associated with impairments in three distinct CT phenotypes of emphysema, large airways, and small airways, even when accounting for smoking status. These results suggest that quantitative CT imaging is an important tool in the identification of sub phenotypes and may inform further investigation into subgroups of patients with COPD who may be more susceptible to the deleterious effects of occupational exposures (45,46). The observed impairments may perhaps serve as an explanation for the myriad of adverse clinical outcomes seen in individuals with a history of occupational exposures.…”

Section: Original Researchmentioning

confidence: 90%

Occupational Exposures and Computed Tomographic Imaging Characteristics in the SPIROMICS Cohort

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Original Researchmentioning

confidence: 90%

Occupational Exposures and Computed Tomographic Imaging Characteristics in the SPIROMICS Cohort

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Although occupation is currently considered an established risk factor for COPD,13 few studies have specifically examined the association between CB and certain occupational exposures,14 particularly dusts and fumes, and most such studies have been cross sectional 5. The European Community Respiratory Health Survey (ECRHS) is a large multicentre population-based longitudinal study that includes detailed information on occupation and respiratory outcomes, and can therefore provide strong prospective evidence.…”

Section: Introductionmentioning

confidence: 99%

Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey

et al. 2019

View full text Add to dashboard Cite

ObjectivesChronic bronchitis (CB) is an important chronic obstructive pulmonary disease (COPD)-related phenotype, with distinct clinical features and prognostic implications. Occupational exposures have been previously associated with increased risk of CB but few studies have examined this association prospectively using objective exposure assessment. We examined the effect of occupational exposures on CB incidence in the European Community Respiratory Health Survey.MethodsPopulation samples aged 20–44 were randomly selected in 1991–1993, and followed up twice over 20 years. Participants without chronic cough or phlegm at baseline were analysed. Coded job histories during follow-up were linked to the ALOHA Job Exposure Matrix, generating occupational exposure estimates to 12 categories of chemical agents. Their association with CB incidence over both follow-ups was examined with Poisson models using generalised estimating equations.Results8794 participants fulfilled the inclusion criteria, contributing 13 185 observations. Only participants exposed to metals had a higher incidence of CB (relative risk (RR) 1.70, 95% CI 1.16 to 2.50) compared with non-exposed to metals. Mineral dust exposure increased the incidence of chronic phlegm (RR 1.72, 95% CI 1.43 to 2.06). Incidence of chronic phlegm was increased in men exposed to gases/fumes and to solvents and in women exposed to pesticides.ConclusionsOccupational exposures are associated with chronic phlegm and CB, and the evidence is strongest for metals and mineral dust exposure. The observed differences between men and women warrant further investigation.

show abstract

“…Exposure to gas, dust and fumes is known to be associated with the severity of COPD and the risk of work disability 24. Furthermore, researchers have found that occupational exposure is associated with elevated morbidity and lower quality of life in people with COPD 25 26. It has also been reported that static hyperinflation (quantified as RV/TLC) was an independent risk factor for all-cause mortality in COPD16 17 and was associated with an elevated risk of COPD exacerbation 17 18.…”

Section: Discussionmentioning

confidence: 99%

Assessment of lung hyperinflation in occupational chronic obstructive pulmonary disease: a multicentric cross-sectional study

de Broucker,

Andujar,

Wardyn

et al. 2023

BMJ Open Resp Res

View full text Add to dashboard Cite

Occupational exposure is associated with elevated morbidity and lower quality of life in patients with chronic obstructive pulmonary disease (COPD). Static hyperinflation is an independent risk factor for all-cause mortality in COPD and for COPD exacerbation. In a multicentre, cross-sectional study (BPROFETIO), we sought to analyse the relationship between static hyperinflation and occupational exposure in patients with COPD with or without occupational exposure.Material and methodsAn overall ‘whole working life’ cumulative exposure index was calculated for occupational patients with COPD. Spirometry indices and lung volumes were measured according to the 2005 American Thoracic Society/European Respiratory Society guidelines.ResultsAfter adjustment for age, sex, height, body mass index, smoking and coexposure, the analysis for each occupational hazard showed a higher risk for hyperinflation and FEV1decline or progression of COPD or GOLD stage for patients with COPD exposed to non-metallic inorganic dusts.ConclusionOccupational exposures should be more investigated in clinical practice and studies as they contribute to the COPD heterogeneity and are associated for some with the development of a static hyperinflation; a condition that is known to have a negative impact on quality of life and survival.

show abstract

Occupational Exposures and Chronic Obstructive Pulmonary Disease. Causality Established, Time to Focus on Effect and Phenotypes

Cited by 4 publications

References 21 publications

Occupational Exposures and Computed Tomographic Imaging Characteristics in the SPIROMICS Cohort

Occupational Exposures and Computed Tomographic Imaging Characteristics in the SPIROMICS Cohort

Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey

Assessment of lung hyperinflation in occupational chronic obstructive pulmonary disease: a multicentric cross-sectional study

Contact Info

Product

Resources

About