Occupational Exposures and Esophageal Cancer: Prog Study

Gressier, Annabelle; Gourier, Greta; Metges, Jean-Philippe; Dewitte, J.-D.; Loddé, Brice; Lucas, David

doi:10.3390/ijerph19169782

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Additionally, it has been proposed that exposure to polycyclic aromatic hydrocarbons (PAHs) is a risk factor for developing esophageal cancer [ 30 ]. Other common chemicals such as asbestos, hydrocarbons and their derivatives, chlorinated solvents, and pesticides might be associated with esophageal cancer [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Esophageal and Head and Neck Cancer Patients Attending Ocean Road Cancer Institute in Tanzania from 2019 to 2021: An Observational Study

Mwelange

Mamuya

Mwaiselage

et al. 2023

IJERPH

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Background: Cancer in Africa is an emerging public health problem that needs urgent preventive measures, particularly in workplaces where exposure to carcinogens may occur. In Tanzania, the incidence rate of cancer and mortality rates due to cancers are increasing, with approximately 50,000 new cases each year. This is estimated to double by 2030. Methods: Our hospital-based cross-sectional study describes the characteristics of newly diagnosed patients with head and neck or esophageal cancer from the Ocean Road Cancer Institute (ORCI), Tanzania. We used an ORCI electronic system to extract secondary data for these patients. Results: According to the cancer registration, there were 611 head and neck and 975 esophageal cancers recorded in 2019–2021. Two-thirds of these cancer patients were male. About 25% of the cancer patients used tobacco and alcohol, and over 50% were involved in agriculture. Conclusion: Descriptions of 1586 head and neck cancer patients and esophageal cancer patients enrolled in a cancer hospital in Tanzania are given. The information may be important for designing future studies of these cancers and may be of value in the development of cancer prevention measures.

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Section: Introductionmentioning

confidence: 99%

Esophageal and Head and Neck Cancer Patients Attending Ocean Road Cancer Institute in Tanzania from 2019 to 2021: An Observational Study

Mwelange

Mamuya

Mwaiselage

et al. 2023

IJERPH

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“…and esophageal cancer. [15] Excess incidence of cancers of the digestive tract are observed within the firefighter population, namely esophageal and colorectal malignancies. [16][17] As such, firefighters have the potential to significantly benefit from an easily accessible, minimally invasive, non-endoscopic screening test for BE.…”

Section: Introductionmentioning

confidence: 99%

Clinical Utility of EsoGuard® as an Efficient Triage Test for Diagnosing Barrett’s Esophagus in On-Duty Firefighters

Hamblin,

Lee,

deGuzman

et al. 2023

Preprint

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BackgroundFirefighters have frequent exposure to smoke and compounds that have been shown to increase the risk of developing esophageal neoplasia. EsoGuard® is a DNA biomarker assay that can be utilized with efficiency and high tolerability as a triage test in the diagnosis of patients with Barrett’s Esophagus (BE) and/or esophageal adenocarcinoma (EAC) in this population.MethodsThis is a retrospective analysis of prospectively collected clinical utility data on use of EsoGuard® DNA testing on samples collected with the nonendoscopic esophageal cell collection device, EsoCheck®, during two large cancer screening events for firefighters in San Antonio, TX, in January 2023.ResultsA total of 388 firefighters volunteered for screening of Barrett’s Esophagus and esophageal adenocarcinoma, of which 385 (>99%) successfully provided cell samples for EsoGuard analysis. There was a 7.27% (28/385) positivity rate, which was similar among males and females (7.26% and 7.41%, respectively). Only 13/385 (3.37%) tests failed analysis due to insufficient DNA sampling. Among those who tested positive with EsoGuard, 100% (28/28) were referred by the ordering physician for gastroenterology and upper endoscopy evaluation. Among those who tested negative, none were referred for upper endoscopy evaluation. This resulted in a 100% concordance between EsoGuard results and physician management decisions.ConclusionsThis study capturing real-world data on the use of EsoGuard for early detection of BE/EAC in firefighters demonstrates the ability of this diagnostic tool to efficiently screen high-risk populations in a manner that is well tolerated, has high result yield, and effectively drives physician management decisions.

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Occupational Exposures and Esophageal Cancer: Prog Study

Cited by 2 publications

References 20 publications

Esophageal and Head and Neck Cancer Patients Attending Ocean Road Cancer Institute in Tanzania from 2019 to 2021: An Observational Study

Esophageal and Head and Neck Cancer Patients Attending Ocean Road Cancer Institute in Tanzania from 2019 to 2021: An Observational Study

Clinical Utility of EsoGuard® as an Efficient Triage Test for Diagnosing Barrett’s Esophagus in On-Duty Firefighters

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