Occupational exposures and risk of dementia‐related mortality in the prospective Netherlands Cohort Study

Koeman, Tom; Schouten, Leo J.; Brandt, Piet A. van den; Slottje, Pauline; Huss, Anke; Peters, Susan; Kromhout, Hans; Vermeulen, Roel

doi:10.1002/ajim.22462

Cited by 21 publications

(17 citation statements)

References 46 publications

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“…Our findings are in line with those previously reported in occupational cohorts, mainly showing detrimental effect in the areas of processing speed and attention 9. Our results are also in agreement with those from the prospective cohort of French national gas and electricity (GAZEL) employees (n=2143 men)6 or from the prospective Netherlands cohort study (n=2411 men) 35. The consistent associations found for the DSST score are particularly interesting because this cognitive test is likely to be one of the most appropriate to examine cognitive performance in younger persons; it is a sensitive test36 requiring sustained attention, processing speed and visual spatial skills, and poor performance on this test has been linked to incident dementia 37…”

Section: Discussionsupporting

confidence: 93%

Association between occupational solvent exposure and cognitive performance in the French CONSTANCES study

et al. 2020

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ObjectiveThe objective of this study was to evaluate the association between occupational exposure to solvents and cognitive performance in middle-aged and early-ageing participants, taking into account the working environment.MethodsIn the French Cohorte des consultants des Centres d'examens de santé (CONSTANCES) cohort, 41 854 participants aged 45–69 years completed a self-reported, lifetime occupational exposure questionnaire. Exposure to solvents (gasoline for hand washing, trichloroethylene, white spirit, cellulosic thinner) was first considered as a binary variable (exposed/not exposed). We computed number of solvent types to which participants were exposed, solvent exposure time and delay since last exposure. Cognitive performance was assessed and analysed in reference to norms of neuropsychological battery previously established in CONSTANCES according to age, sex and education. Multiple linear and modified Poisson regression were used to estimate the associations between solvent exposure and cognitive performance adjusting for individual and environmental characteristics, and working conditions (night shift, repetitive and noisy work).ResultsMen had a greater risk of global cognitive impairment when they were exposed to gasoline (relative risk (RR)=1.12, 95% CI 1.03 to 1.22), white spirit (RR=1.14, 95% CI 1.05 to 1.25) or cellulosic thinner (RR=1.17, 95% CI 1.06 to 1.31) at the workplace, even after adjusting for confounders. Women exposed to white spirit or exposed for more than 20 years had poorer global cognitive performance.ConclusionThese findings strengthen our understanding of the detrimental effect of solvent exposure on cognitive health not only in men but also in women for the first time, in a large general population middle-aged and early-ageing sample from France, taking into account working conditions.

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Section: Discussionsupporting

confidence: 93%

Association between occupational solvent exposure and cognitive performance in the French CONSTANCES study

et al. 2020

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“… “For lead exposure there are no data supporting any association. All the studies are case–control studies, with a relatively low level of quality according to our classification.” (p. 730) - Koeman et al 2015 [ 63 ] Metals (occupational exposure) The Netherlands Cohort Study which consisted of 120,852 individuals aged 55–69 years in 1986. 682 men and 870 women who had died with non-VaD reported on their death certificates over 17 years follow up.…”

Section: Resultsmentioning

confidence: 99%

Environmental risk factors for dementia: a systematic review

et al. 2016

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BackgroundDementia risk reduction is a major and growing public health priority. While certain modifiable risk factors for dementia have been identified, there remains a substantial proportion of unexplained risk. There is evidence that environmental risk factors may explain some of this risk. Thus, we present the first comprehensive systematic review of environmental risk factors for dementia.MethodsWe searched the PubMed and Web of Science databases from their inception to January 2016, bibliographies of review articles, and articles related to publically available environmental data. Articles were included if they examined the association between an environmental risk factor and dementia. Studies with another outcome (for example, cognition), a physiological measure of the exposure, case studies, animal studies, and studies of nutrition were excluded. Data were extracted from individual studies which were, in turn, appraised for methodological quality. The strength and consistency of the overall evidence for each risk factor identified was assessed.ResultsWe screened 4784 studies and included 60 in the review. Risk factors were considered in six categories: air quality, toxic heavy metals, other metals, other trace elements, occupational-related exposures, and miscellaneous environmental factors. Few studies took a life course approach. There is at least moderate evidence implicating the following risk factors: air pollution; aluminium; silicon; selenium; pesticides; vitamin D deficiency; and electric and magnetic fields.ConclusionsStudies varied widely in size and quality and therefore we must be circumspect in our conclusions. Nevertheless, this extensive review suggests that future research could focus on a short list of environmental risk factors for dementia. Furthermore, further robust, longitudinal studies with repeated measures of environmental exposures are required to confirm these associations.

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“…Vergara et al (2013) found no indication of an association with dementia (RR 1.05, 95% CI 0.96-1.14) based on nine studies, but they did not distinguish between different levels of exposure. In a recent cohort study in the Netherlands, Koeman et al (2015) found an association between high occupational ELF-MF exposure and non-vascular dementia-related mortality in men (RR 1.40, 95% CI 0.92-2.14), however, not with cumulative exposure. Koeman et al (2015) concluded that the observed association was likely to be attributed to exposure to metals, with which the ELF-MF exposure was highly correlated.…”

Section: Comparison With Previous Follow-ups In the Cohort And Other mentioning

confidence: 92%

Occupational exposure to extremely low-frequency magnetic fields and risk for central nervous system disease: an update of a Danish cohort study among utility workers

Pedersen

Poulsen

Rod

et al. 2017

Int Arch Occup Environ Health

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Occupational exposures and risk of dementia‐related mortality in the prospective Netherlands Cohort Study

Abstract: Consistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature.

Cited by 21 publications

References 46 publications

Association between occupational solvent exposure and cognitive performance in the French CONSTANCES study

Association between occupational solvent exposure and cognitive performance in the French CONSTANCES study

Environmental risk factors for dementia: a systematic review

Occupational exposure to extremely low-frequency magnetic fields and risk for central nervous system disease: an update of a Danish cohort study among utility workers

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