Occupational exposures to metals, solvents and pesticides: recent evidence on male reproductive effects and biological markers

Figà–Talamanca, Irene; Traina, M.E.; Urbani, Elisabetta

doi:10.1093/occmed/51.3.174

Cited by 98 publications

(44 citation statements)

References 65 publications

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“…Although the sitting position may cause increase of scrotal temperature, this increase seems not strong enough to disrupt spermatogenesis that may recover during other parts of the day [13,14]. Research during past 25 years has identified a large number of chemicals and occupational exposures that may impair male fertility (Table 1) [15][16][17][18][19][20][21][22][23][24][25][26]. It should, however, be acknowledged that epidemiological studies of male fertility and semen quality are beset with a number of pitfalls and methodological limitations crude exposure assessment, low participation rates, inadequate study size and lacking quality assurance of the semen analysis [27,28].…”

Section: Occupational Hazardsmentioning

confidence: 99%

“…In 1995 the US Institute of Medicine Committee stated that "the prevailing view is that exposure of the human male to chemicals and ionizing radiation is generally unrelated to the occurrence of developmental endpoints such as miscarriage, birth defects, growth retardation and Table 1. Chemical and physical exposures that have been associated with reduced semen quality or impaired male fertility (for systematic reviews, see [15][16][17][18][19][20][21][22][23][24][25][26] npg cancer" [56]. The question is, however, whether lack of convincing examples of male mediated developmental toxicity in humans is due to the non-existence of this phenomenon due to huge methodological challenges in demonstrating effects.…”

Section: Male Mediated Development Toxicitymentioning

confidence: 99%

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Male reproductive organs are at risk from environmental hazards

Bonde¹

2009

Asian J Androl

108

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Male reproductive disorders that are of interest from an environmental point of view include sexual dysfunction, infertility, cryptorchidism, hypospadias and testicular cancer. Several reports suggest declining sperm counts and increase of these reproductive disorders in some areas during some time periods past 50 years. Except for testicular cancer this evidence is circumstantial and needs cautious interpretation. However, the male germ line is one of the most sensitive tissues to the damaging effects of ionizing radiation, radiant heat and a number of known toxicants. So far occupational hazards are the best documented risk factors for impaired male reproductive function and include physical exposures (radiant heat, ionizing radiation, high frequency electromagnetic radiation), chemical exposures (some solvents as carbon disulfide and ethylene glycol ethers, some pesticides as dibromochloropropane, ethylendibromide and DDT/DDE, some heavy metals as inorganic lead and mercury) and work processes such as metal welding. Improved working conditions in affluent countries have dramatically decreased known hazardous workplace exposures, but millions of workers in less affluent countries are at risk from reproductive toxicants. New data show that environmental low-level exposure to biopersistent pollutants in the diet may pose a risk to people in all parts of the world. For other toxicants the evidence is only suggestive and further evaluation is needed before conclusions can be drawn. Whether compounds as phthalates, bisphenol A and boron that are present in a large number of industrial and consumer products entails a risk remains to be established. The same applies to psychosocial stressors and use of mobile phones. Finally, there are data indicating a particular vulnerability of the fetal testis to toxicants-for instance maternal tobacco smoking. Time has come where male reproductive toxicity should be addressed form entirely new angles including exposures very early in life.

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Section: Occupational Hazardsmentioning

confidence: 99%

Section: Male Mediated Development Toxicitymentioning

confidence: 99%

Male reproductive organs are at risk from environmental hazards

Bonde¹

2009

Asian J Androl

108

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“…Occupational activities involving exposure to specific chemicals or expositions to toxicants may impair male reproductive health and cause infertility in humans [27,37,[42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58].…”

Section: Introductionmentioning

confidence: 99%

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Ten¹,

Mendiola²,

Torres-Cantero³

et al. 2008

TORSJ

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Human semen quality may be declining due to environmental pollutants, occupational exposures or changes in lifestyle. Nonetheless, we still know little about the impact of those factors on male fertility. Some heavy metals, volatile organic compounds or xenoestrogens may compromise reproductive male function. This process could take place along the human life cycle and not only in certain stages of development. We review the main factors that affect human male fertility and their possible influence in current human reproduction.

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“…Obesity and smoking are thought to be some of the most critical among these factors [4][5][6][7][8][9][10][11][12][13][14][15][16]. It has also been established that some drugs, heavy metals and solvents, may affect fertility [17][18][19]. However, there is relatively little data regarding IVF success depending on the type of area inhabited by the patient [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Demographic characteristics and AMH levels in rural and urban women participating in an IVF programme

Kunicki¹,

Łukaszuk²,

Liss³

et al. 2018

Ann Agric Environ Med.

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Objective. The primary aim of this preliminary study was to compare the IVF results of couples living in rural and urban areas. Additionally, the ovarian reserve parameters, such as AMH concentrations, were compared for the same groups. Materials and method. The database of 1,265 women undergoing in vitro fertilization at the Invicta Fertility Center between May 2011-July 2012 were retrospectively analyzed. Women undergoing their first assisted reproductive technology cycle with ICSI, stimulated according to the long protocol, and whose AMH levels were measured using the same DSL kit, were selected. Ultimately, 651 women were included in the study. All participants were categorized based on the area where they live: rural areas, small towns (<100,000 inhabitants) and large cities (>100,000) Results. The mean age of the patients living in large cities was significantly higher in comparison to those from rural areas and small towns. A significantly higher pregnancy body mass index (BMI) was found in women from rural areas in comparison to the women living in small and large towns. Serum AMH and inhibin B concentrations, number of ampules of gonadotropins, and antral follicle count (AFC), did not differ significantly among the groups. The study showed no significant differences among the groups in terms of clinical pregnancy rate, both per started cycle and per embryo transfer. Conclusions. No significant differences were found in IVF outcomes among the groups inhabiting rural areas, small and large cities.

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Occupational exposures to metals, solvents and pesticides: recent evidence on male reproductive effects and biological markers

Cited by 98 publications

References 65 publications

Male reproductive organs are at risk from environmental hazards

Male reproductive organs are at risk from environmental hazards

Occupational and Lifestyle Exposures on Male Infertility: A Mini Review

Demographic characteristics and AMH levels in rural and urban women participating in an IVF programme

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