The purpose of the study was to obtain new data on the causes, development, prevalence and nature of occupational multimorbidity in the nickel industry workers. We extracted data from the register of occupational disease and intoxication cases in the population of the Murmansk region and the Krasnoyarsk Territory in 2007–2021. In 2007–2021, 24.6% of nickel industry workers with newly diagnosed occupational diseases developed a multimorbid pathology. Its prevalence rose from 0% in 2007 to 83.3% in 2021, and the number of occupational diseases increased by 3.17 times. Two diagnoses were found in 66 (14.9%), three in 22 (5.0%), four in fifteen (3.4%), five in eleven (2.5%), and six in three (0.7%) employees. Respiratory and musculoskeletal diseases were the most prevalent disorders, accounting for 31.5% and 23.0% of cases, respectively. Occupational multimorbidity resulted from the increased combined exposure to occupational hazards, outdated technological processes, and the working conditions in the finished product cleaners and crane operators. Multimorbid diseases can be better prevented with improvement in working conditions and better quality of periodic medical examinations.