Introduction: Occupational balance is a fundamental concept that plays an influential role in enhancing health and well-being. Method: The Persian Occupational Balance Questionnaire-11 was administered to 157 healthy individuals in the test phase and 80 healthy individuals in the retest phase. Floor or ceiling effects, construct validity, discriminant validity, internal consistency reliability, test–retest reliability, standard error of the measurement and smallest detectable change were examined. Results: The Persian Occupational Balance Questionnaire-11 showed no missing responses. There were no floor or ceiling effects for the total score. The independent t-test did not show a statistically significant difference between groups (based on age category, marital status and job status) that didn’t support discriminant validity. Factor analysis demonstrated a three-factor solution for the Persian Occupational Balance Questionnaire-11 which jointly accounted for 57.62% of the total variance. There was high internal consistency for test (α = 0.813) and retest (α = 0.853). The test–retest reliability for Persian Occupational Balance Questionnaire-11 with a 1-week interval was excellent (ICCagreement = 0.880). The standard error of the measurement and smallest detectable change were 2.02 and 5.60, respectively. Conclusion: Persian Occupational Balance Questionnaire-11 is a valid and reliable instrument for assessing occupational balance in healthy Persian-speaking participants.