Occupational immediate‐type asthma and rhinitis due to rhodium salts

Merget, R.; Sander, I.; Kampen, V. van; Raulf‐Heimsoth, Monika; Ulmer, Hans-Martin; Kulzer, Rupprecht; Bruening, Thomas H.

doi:10.1002/ajim.20786

Cited by 36 publications

(15 citation statements)

References 19 publications

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“…Nevertheless, allergic contact dermatitis caused by rhodium salts has been recently demonstrated in subjects working in jewelry trade (Goossens et al 2011) and one case of immediate-type asthma and rhinitis due to rhodium salts has been demonstrated in a electroplating plant worker (Merget et al 2010). Iavicoli et al (2012) demonstrated in vitro cell cycle arrest and DNA damage on fibroblasts treated with rhodium and iridium salts, with an earlier effect in rhodium treated cells.…”

Section: Discussionmentioning

confidence: 98%

Permeation of platinum and rhodium nanoparticles through intact and damaged human skin

et al. 2015

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The aim of the study was to evaluate percutaneous penetration of platinum and rhodium nanoparticles (PtNPs: 5.8 ± 0.9 nm, RhNPs: 5.3 ± 1.9 nm) through human skin. Salts compounds of these metals are sensitizers and some also carcinogenic agents. In vitro permeation experiments were performed using Franz diffusion cells with intact and damaged skin. PtNPs and RhNPs, stabilized with polyvinylpyrrolidone, were synthesized by reduction of Na2PtCl6 and RhCl3·3H2O respectively. Suspensions with a concentration of 2.0 g/L of PtNPs and RhNPs were dispersed separately in synthetic sweat at pH 4.5 and applied as donor phases to the outer surface of the skin for 24 h. Measurements of the content of the metals in the receiving solution and in the skin were performed subsequently. Rhodium skin permeation was demonstrated through damaged skin, with a permeation flux of 0.04 ± 0.04 μg cm−2 h−1 and a lag time of 7.9 ± 1.1 h, while no traces of platinum were found in receiving solutions. Platinum and rhodium skin-analysis showed significantly higher concentrations of the metals in damaged skin. Rh and Pt applied as NPs can penetrate the skin barrier and Rh can be found in receiving solutions. These experiments pointed out the need for skin contamination prevention, since even a minor injury to the skin barrier can significantly increase penetration

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Section: Discussionmentioning

confidence: 98%

Permeation of platinum and rhodium nanoparticles through intact and damaged human skin

et al. 2015

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“…Since 2008 several case reports of occupational rhinitis caused by sensitizers, both high and low molecular weight (LMW) agents, seldom if ever described previously, have been published (Table 1) [20][21][22][23][24][25][26][27][28][29][30][31]. In the majority of cases occupational rhinitis was associated with occupational asthma and atopy [20,[22][23][24][25][26][27][28][29][30].…”

Section: 'New' Agents Causing Occupational Rhinitismentioning

confidence: 99%

“…In the majority of cases occupational rhinitis was associated with occupational asthma and atopy [20,[22][23][24][25][26][27][28][29][30]. The diagnosis was based on work-related rhinitis symptoms, specific skin prick test (SPT) and inhalation challenges.…”

Section: 'New' Agents Causing Occupational Rhinitismentioning

confidence: 99%

Occupational rhinitis: consensus on diagnosis and medicolegal implications

Moscato

Rolla

Siracusa

2011

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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“…Hairdressers and other beauty care professionals can develop occupational rhinitis after exposures to bleaching agents containing persulfate, oxidative hair dyes with paraphenylene diamine or toluene-2,5-diamine sulfate, and glues containing ethyl cyanoacrylate used to apply eyelash extensions [21][22][23]. In regards to metals, a 27-year-old male factory operator in an electroplating plant was reported to have developed occupational rhinitis secondary to his exposure to rhodium salts [24]. Finally, occupational rhinitis has been described in a nurse exposed to the hospital disinfectant chlorhexidine and separately in a pharmaceutical worker who was exposed to the medication sodium alendronate during packaging [25,26].…”

Section: Etiologic Agentsmentioning

confidence: 99%

Occupational Rhinitis: an Update

Stevens

Grammer

2014

Curr Allergy Asthma Rep

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Occupational rhinitis is characterized by nasal congestion, rhinorrhea, nasal itching, and/or sneezing that occur secondary to exposures in the workplace. This disease can be classified into allergic or nonallergic subgroups based upon the underlying disease pathogenesis as well as the type of causative agent. While the true prevalence of occupational rhinitis is unknown, there are certain professions and occupational exposures that place workers at a higher risk for developing the disease. Additionally, occupational rhinitis can be associated with occupational asthma and upper airway symptoms may precede those of the lower respiratory tract. Taken together, occupational rhinitis is an important disease for study given its medical as well as socioeconomic implications. This review will focus on the classification of occupational rhinitis as well the prevalence, diagnosis, and treatment strategies.

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Occupational immediate‐type asthma and rhinitis due to rhodium salts

Abstract: Rhodium salts should be considered as occupational immediate-type allergens.

Cited by 36 publications

References 19 publications

Permeation of platinum and rhodium nanoparticles through intact and damaged human skin

Permeation of platinum and rhodium nanoparticles through intact and damaged human skin

Occupational rhinitis: consensus on diagnosis and medicolegal implications

Occupational Rhinitis: an Update

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