Occupational Lead Exposure and Blood Pressure

Wu, Trong-Neng; Shen, Chen‐Yang; Ko, Kque-Nu; Guu, Chiam-Fang; Gau, Huey-Jiuan; Lai, Jin-Shin; Chen, Chen-Jen; Chang, Po-Ya

doi:10.1093/ije/25.4.791

Cited by 40 publications

(26 citation statements)

References 2 publications

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“…In a study of Boston police officers with levels somewhat higher than the current general population, there was a statistically significant association between a high (>30 µg/dl) blood lead level and subsequent elevation in systolic pressure after 5 yr. Two meta-analyses that examined the studies of blood lead and blood pressure are in agreement that there is a correlation between the two parameters, though the magnitude and clinical significance is debatable 2) . In addition, other studies 3,4) did not indicate any relationship between exposure to lead and blood pressure.…”

Section: Introductionmentioning

confidence: 81%

Relationship of Blood Lead Levels to Blood Pressure in Exhaust Battery Storage Workers

et al. 2006

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Several researches has focused the hypothesis that low blood lead levels could be associated with an increased risk of hypertension. To assess the relation between occupational lead exposure and elevated blood pressure a group of 27 workers, age range from 27 to 62 years, mean (SD) 36.52 ( 8.16) yr; length of employment mean (DS) 2.97 ( 1.67) yr, were recruited as study subjects. The following variables were measured: blood lead concentration (BPb), δ-Aminolevulinic Acid Dehydratase (ALAD) activity, Zinc Protoporphirin (ZPP), creatinine, hematocrit, Body Mass Index (BMI) and Systolic Blood Pressure (SBP) and Diastolic Blood (DBP) Pressure. The results showed that long term occupational exposure was related to a slight increase of systolic and diastolic blood pressure among workers who had been exposed to higher level of lead with respect to workers exposed to lower level of lead. Furthermore, blood lead concentration (BPb) and ZPP resulted higher among workers exposed to higher level of ambient lead, while in the same group of workers ALAD activity resulted more inhibited. The authors concluded long term cumulative lead exposure can significantly increase blood pressure in low level Pb exposed workers.

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Section: Introductionmentioning

confidence: 81%

Relationship of Blood Lead Levels to Blood Pressure in Exhaust Battery Storage Workers

et al. 2006

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“…Blood lead determinations were performed at the Faculty of Science and Central Laboratories Unit, UAE University with a Philips PU 9100X (Byunikan) atomic absorption spectrophotometer (AAS) equipped with graphite furnace and Zeeman background correction system. The analytical method used followed that described by Wu et al (1996). All specimens were analyzed three times and the average was taken when the relative standard deviation was less than 5%.…”

Section: Analysis Of Blood Lead Concentrationsmentioning

confidence: 99%

“…In addition, signi®cant correlations between blood lead and a variety of risk factors for cardiovascular disease (CVD) such as hypertension (Wu et al 1996;Schwartz 1988;Weiss et al 1986), and diabetes mellitus (DM) have been well-established Hayashi et al 1999);Schwartz 1995;DeFronzo 1997;Bener et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Association between blood levels of lead, blood pressure and risk of diabetes and heart disease in workers

Bener¹,

Obineche

Gillett

et al. 2001

International Archives of Occupational and Environmental Health

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“…M ost, [1][2][3][4][5][6][7][8][9][10] but not all, [11][12][13][14][15][16] studies have indicated that environmental exposure to lead is associated with an increased risk of hypertension and renal disease. A strong association between blood lead level and prevalence of hypertension was noted in the Second National Health and Nutrition Examination Survey (NHANES II).…”

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confidence: 99%

Blood Lead Level Is Associated With Elevated Blood Pressure in Blacks

et al. 2003

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Abstract-Chronic lead exposure has been associated with elevated blood pressure in epidemiological studies. It is not known whether the previously observed relation between blood lead and hypertension persists after significant reductions have been made in environmental lead contamination. We examined the relation between blood lead levels and blood pressure in a representative sample of 14 952 whites and blacks aged 18 years or older who participated in the Third National Health and Nutrition Examination Survey. Blood lead was measured by atomic absorption spectrophotometry and blood pressure by standard sphygmomanometry. Mean blood lead levels were significantly higher for black men and women (5.4 and 3.4 g/dL, respectively) compared with white men and women (4.4 and 3.0 g/dL, respectively). Key Words: blood pressure Ⅲ ethnic groups Ⅲ blood lead Ⅲ blacks Ⅲ epidemiology M ost, 1-10 but not all, 11-16 studies have indicated that environmental exposure to lead is associated with an increased risk of hypertension and renal disease. A strong association between blood lead level and prevalence of hypertension was noted in the Second National Health and Nutrition Examination Survey (NHANES II). 4,17,18 The NHANES II was conducted during 1976 and 1980, when many of the current environmental measures, such as reduction in use of leaded gasoline, had not been adopted or had not been in place long enough to have a measurable effect on lead pollution. [17][18][19] In recent years, a strong secular trend toward decreasing blood lead concentrations has been noted in the general population. For example, among the US population aged 1 to 74 years, mean blood lead concentrations dropped by 78%, from 12.8 g/dL to 2.8 g/dL between 1976 to 1980 (NHANES II) and 1988 to 1991 (the first phase of the Third National Health and Nutrition Examination Survey [NHANES III]). 8,19 -21 Whether the relation between blood lead level and blood pressure (BP) is still present after this marked decline in environmental lead exposure is unknown. The present study examined the relation between blood lead level and BP in a large representative sample of blacks and whites who participated in NHANES III. Methods Study ParticipantsThe NHANES III was conducted by the National Center for Health Statistics between 1988 and 1994. Details of the NHANES III study participants and methods have been published elsewhere. 22 In brief, a stratified multistage probability design was used to obtain a representative sample of the civilian noninstitutionalized US general population. To improve the precision of estimates in certain subgroups, the design included oversampling of the very young, the elderly, blacks, and Mexican-Americans. A total of 19 618 participants 18 years of age and older were included in NHANES III. Participants were excluded from the current analysis when their self-reported race was not white or black (nϭ635) or when data on blood lead (nϭ3936) or BP (nϭ95) were missing. A total of 10 548 whites and 4404 blacks were included in the main analysi...

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Occupational Lead Exposure and Blood Pressure

Cited by 40 publications

References 2 publications

Relationship of Blood Lead Levels to Blood Pressure in Exhaust Battery Storage Workers

Relationship of Blood Lead Levels to Blood Pressure in Exhaust Battery Storage Workers

Association between blood levels of lead, blood pressure and risk of diabetes and heart disease in workers

Blood Lead Level Is Associated With Elevated Blood Pressure in Blacks

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