Occupational respiratory diseases in British Columbia, Canada in 1991.

Contreras, Gustavo R; Rousseau, Roxanne; Chan‐Yeung, Moira

doi:10.1136/oem.51.10.710

Cited by 80 publications

(38 citation statements)

References 6 publications

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“…Asthma is one of the most commonly diagnosed occupational lung disorders [Sallie et al, 1994;Contreras et al, 1994]. Cases of work-related asthma are preventable and identification of workplaces or job titles that have an increased risk of asthma could lead to a decrease in the rate of the disease if appropriate control strategies were put in place.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of physician-diagnosed asthma by occupational groupings in Manitoba, Canada

Kraut¹,

Walld²,

Mustard³

1997

Am. J. Ind. Med.

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Section: Introductionmentioning

confidence: 99%

Prevalence of physician-diagnosed asthma by occupational groupings in Manitoba, Canada

Kraut¹,

Walld²,

Mustard³

1997

Am. J. Ind. Med.

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“…The aim of SENSOR is not to measure disease frequency; the incidence figure is therefore not comparable to the other reporting schemes. Similar sentinel programmes have been run elsewhere [62].…”

Section: Sentinel Programmesmentioning

confidence: 99%

Controversies in epidemiology of occupational asthma

Gautrin¹,

Aj²,

Nordman³

et al. 2003

Eur Respir J

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high-risk workplaces, medicolegal statistics and sentinel programmes indicate that y10% of adult-onset asthma is attributable to the workplace. The strategy to identify cases through questionnaires and tools that address functional, immunological and physiopathological issues needs to be improved.Although few in number and limited to a handful of workplaces, cohort studies found that the risk of developing occupational asthma is determined less by individual susceptibility (e.g. atopy, tobacco smoking, human leukocyte antigen phenotype) and more by the level of exposure to its causes; in general, the higher the exposure, the greater the risk, and, by implication, lowering the level of exposure reduces the incidence of disease.Occupational asthma can be used as a satisfactory model for the development of adult-onset asthma. There is a great need to develop intervention strategies through adequate surveillance programmes in high-risk workplaces. Eur Respir J 2003; 22: 551-559. Epidemiology of occupational asthma: general considerations on various study designs and methodological approachesEpidemiology is the study of the distribution, determinants and outcome of disease. In this article, the authors will describe recently acquired knowledge of the epidemiology of occupational asthma, as well as current areas of controversy.BECKLAKE et al.[1] have discussed the features, strengths and weaknesses of several designs used in epidemiological studies. These designs include the randomised control trial, the prospective cohort, the case-referent study, the crosssectional (prevalence) study and the case series. Which design to use in any particular situation is a matter of judgment, determined by a number of factors that may include resources, cost, collaboration of employers and employees, and the question under study. So far, primarily for practical convenience, most epidemiological studies of occupational asthma have been cross-sectional in type. As discussed in several reviews [1,2], this type of study, primarily in the case of occupational asthma (OA), suffers from survivor bias, whose magnitude can be difficult to quantify. Randomised control trials are usually not feasible and are probably unethical in workplace studies, but quasi-experimental studies can provide results of high internal and external validity. Prospective cohort studies are more expensive than cross-sectional studies but are more powerful and less likely to be affected by selection or survivor biases; in particular, it is often possible to track the participants who leave the cohort and determine the possible effect of attrition on the estimates of both the frequency of OA and exposure/effect relationships [3]. This type of study has recently been successfully applied in cohorts of young apprentices [4][5][6][7][8][9][10]. Some case-referent studies have been carried out in the field of OA [11,12]. These studies are valuable in identifying and quantifying risk factors. Finally, there are many case series that mainly describe clinical cases (often si...

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“…OA is becoming the principal cause of work-related respiratory ailment in industrialized countries, accounting for 26-50% of new cases of occupational lung disease [67][68][69][70]. Estimates of the annual incidence of OA range 20-140 per million workers [70].…”

Section: Clinical Purposesmentioning

confidence: 99%

Inhalation challenges with agents causing occupational asthma

Vandenplas¹,

Jl²

1997

Eur Respir J

124

103

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Occupational asthma (OA) is steadily emerging as the principal cause of respiratory disease due to the workplace environment. One of the key means to ascertain diagnosis of OA is specific inhalation challenge (SIC) with occupational agents. This review: 1) describes the methodology of SIC, with a special emphasis on procedures aimed at increasing the safety and validity of these tests; and 2) outlines the roles of SIC in the diagnosis of OA in clinical and medicolegal assessment, epidemiological studies, surveillance programmes and the investigation of the pathophysiological mechanisms of asthma and OA. We discuss areas of future development, including the development of apparatus which allows exposure of subjects to low and stable concentrations of the occupational agent and the assessment of preventive procedures.

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Occupational respiratory diseases in British Columbia, Canada in 1991.

Cited by 80 publications

References 6 publications

Prevalence of physician-diagnosed asthma by occupational groupings in Manitoba, Canada

Prevalence of physician-diagnosed asthma by occupational groupings in Manitoba, Canada

Controversies in epidemiology of occupational asthma

Inhalation challenges with agents causing occupational asthma

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