Occupational risk and chronic kidney disease: a population-based study in the United States adult population

Rubinstein, Sofia; Wang, Chengwei; Qu, Wenchun

doi:10.2147/ijnrd.s39522

Cited by 13 publications

(13 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In humans, long-term misalignment of intrinsic circadian rhythms with geophysical time (e.g., shift work) is increasingly recognized as a risk factor for the development of hypertension and progression of CKD. 10,11 In genetic studies, Woon et al 12 have identified several polymorphisms in the promoter region of the human Bmal1 gene that are associated with hypertension. However, to what extent the pathogenesis of these disorders is caused by a defect in the master clock and/or the local circadian clocks in different peripheral tissues remains unknown.…”

mentioning

confidence: 99%

Local Renal Circadian Clocks Control Fluid–Electrolyte Homeostasis and BP

Tokonami¹,

Mordasini²,

Pradervand

et al. 2014

Journal of the American Society of Nephrology

107

101

View full text Add to dashboard Cite

The circadian timing system is critically involved in the maintenance of fluid and electrolyte balance and BP control. However, the role of peripheral circadian clocks in these homeostatic mechanisms remains unknown. We addressed this question in a mouse model carrying a conditional allele of the circadian clock gene Bmal1 and expressing Cre recombinase under the endogenous Renin promoter (Bmal1 Cre mice exhibited multiple abnormalities, including increased urine volume, changes in the circadian rhythm of urinary sodium excretion, increased GFR, and significantly reduced plasma aldosterone levels. These changes were accompanied by a reduction in BP. These results show that local renal circadian clocks control body fluid and BP homeostasis. Circadian rhythmicity is a feature of a wide variety of physiologic functions. Many of the functional rhythms are driven by the circadian timing system, a complex mechanism that coordinates all major cellular processes with geophysical time. It is thought that this coordination allows for the anticipatory adaptation of cells and tissues to the circadian changes in functional requirements. The circadian timing system is organized in a hierarchical manner. The master clock of the system is located in the suprachiasmatic nucleus of the hypothalamus and synchronized to the daily light/dark cycle through the retinohypothalamic tract. The peripheral circadian clocks, which are present in virtually all peripheral tissues, are synchronized to geophysical time through a wide range of master clock-dependent stimuli, many of which remain unknown (reviewed in ref. 1 ). It is important to note, however, that, despite the hierarchical structure of the circadian timing system and its continuous resetting by environmental time cues, the intrinsic activity of both central and peripheral circadian clocks is largely self-sustained. On the molecular level, the master clock and peripheral clocks share similar machinery based on transcriptional/translational feedback loops involving transcriptional activators BMAL1, CLOCK, and NPAS2 and their own repressors PER1 and PER2 as well as CRY1 and CRY2 (reviewed in ref. 2 ).The circadian timing system is critically involved in the maintenance of fluid and electrolyte balance

show abstract

mentioning

confidence: 99%

Local Renal Circadian Clocks Control Fluid–Electrolyte Homeostasis and BP

Tokonami¹,

Mordasini²,

Pradervand

et al. 2014

Journal of the American Society of Nephrology

107

101

View full text Add to dashboard Cite

show abstract

“…Penelitian pada pekerja pabrik semen di Irak dan Arab Saudi menunjukkan peningkatan signifikan ureum dan kreatinin yang merupakan efek nefrotoksik akibat paparan debu silika dan logam berat. 8,9 Berdasarkan hal tersebut peneliti tertarik untuk mengetahui perbedaan fungsi ginjal melalui pemeriksaan kadar ureum dan kreatinin serum pada masyarakat di daerah terpapar dengan yang tidak terpapar emisi pabrik PT. Semen Padang.…”

Section: Pendahuluanunclassified

“…Penelitian ini sesuai dengan penelitian lainnya yang mendapatkan peningkatan kreatinin yang bermakna dibandingkan kontrol. 8,9 Penelitian lainnya memperlihatkan hasil yang berbeda yaitu terdapat peningkatan bermakna ureum dan kreatinin yang menggunakan subjek pekerja pabrik semen dengan intensitas paparan 8 jam dengan nilai ambang PM >25µg/m 3 per hari. Perbedaan ini disebabkan karena perbedaan lamanya paparan emisi pabrik semen dan kadar paparan PM dalam 24 jam pada subjek penelitian ini.…”

Section: Metodeunclassified

Perbandingan Kadar Ureum dan Kreatinin Serum Masyarakat Terpapar dengan Tidak Terpapar Emisi Pabrik PT. Semen Padang

Purwinanty¹,

Yaswir²,

Efrida³

2018

JKA

View full text Add to dashboard Cite

AbstrakEmisi pabrik semen tidak hanya berisiko pada pekerja di pabrik semen, tetapi berdampak pada penduduk yang tinggal di daerah sekitarnya. Penelitian epidemiologi menunjukkan bahwa konsentrasi PM (particulate matter) di udara memiliki korelasi dengan tingkat mortalitas dan morbiditas. Emisi pabrik semen terutama particulate matter bersifat nefrotoksik. Penelitian ini bertujuan mengetahui perbandingan kadar ureum dan kreatinin masyarakat yang terpapar dengan tidak terpapar emisi pabrik semen. Penelitian ini merupakan penelitian analitik dengan rancangan potong lintang terhadap 152 subjek terpapar dan 169 subjek tidak terpapar dari bulan Juni 2015-September 2016. Parameter yang diperiksa adalah ureum menggunakan metode enzimatik (glutamat dehidrogenase) dan pemeriksaan kreatinin menggunakan metode kolorimetri (Jaffe). Hasil pemeriksaan dianalisis menggunakan uji t, bermakna bila p <0,05. Subjek penelitian daerah terpapar terdiri dari laki-laki 33 orang (21,7%) dan perempuan 119 orang (78,3%) dengan rentang umur 19-75 tahun sedangkan daerah tidak terpapar terdiri dari laki-laki 18 orang (10,7%) dan perempuan 151 orang (89,3%) dengan rentang umur 20-80 tahun. Kadar rerata ureum daerah terpapar 17,53(6,7) mg/dL dan kadar rerata ureum daerah tidak terpapar 17,22(5,1) mg/dL, hasil statistik tidak menunjukkan perbedaan bermakna (p<0,05). Kadar rerata kreatinin daerah terpapar 0,85(0,3) mg/dL dan kadar rerata kreatinin daerah tidak terpapar 0,79(0,2) mg/dL, hasil statistik menunjukkan perbedaan bermakna (p <0,05). Kadar kreatinin pada masyarakat terpapar emisi pabrik PT. Semen Padang lebih tinggi tetapi masih dalam batas normal sedangkan kadar ureum tidak menunjukkan perbedaan. Penelitian kohort prospektif diperlukan untuk mendapatkan gambaran perjalanan penyakit berdasarkan lama paparan. Kata kunci: Emisi pabrik semen, kreatinin, ureumAbstract Cement factory emission not only affect the factory workers but also affected people who live around the cement factory. Epidemiologycal studies showed the correlation of morbidity and mortality with the concentration of particulate matter (PM) in the air. Cement factory emission, especially particulate matter is nefrotoxic. The aim of this study is to compare ureum and creatinine level in people exposed and unexposed to cement factory emission. This was an analytical study with cross-sectional design of one hundred fifty two exposed subject and one hundred sixty nine unexposed subject from June 2015 until September 2016. This study investigated ureum and creatinin level, which was enzymatic (glutamate dehydrogenase) for ureum level and colorimetric method (Jaffe) for creatinine level. Test result were analyzed using t-test, significant if p <0,05. Subject in exposed area are thirty three males (21,7%) and one hundred nineteen females (78,3%), age was nineteen until seventy five years old, in unexposed area are 18 males (10,7%) and 151 females (89,3%) with age 20-80 years old. The mean level of ureum in exposed people 17,53(6,7) mg/dL, and in unexposed people was 17,22(5,1) ...

show abstract

“…Several risk factors have been proposed for CKD, including diabetes mellitus (DM), hypertension (HTN), hyperlipidemia, hyperuricemia, anemia, coronary artery disease (CAD), smoking, drugs, infections, family history, and urinary tract obstruction [5,6,7]. Risk factors for subsequent ESRD are higher levels of proteinuria, higher serum creatinine and uric acid levels, obesity, nonwhite race, lower education status, HTN, and DM [5].…”

Section: Introductionmentioning

confidence: 99%

“…A study on the difference of dialysis use and survival between diabetic physicians and the diabetic general population suggested that an above-average medical knowledge of one’s own physical situation and more professional resources affect the outcome [12]. High work stress and night shifts are associated with increased sympathetic activity [6,13,14], which is a risk factor for renal disease [6,15,16,17,18]. A population-based study in the United States reported that health care practitioners had a higher risk for CKD, which may be related to their high work stress and night shifts [6].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Risk for End-Stage Renal Disease Between Physicians and the General Population: A Nationwide Population-Based Cohort Study

Yen

Tan

Feng

et al. 2019

IJERPH

View full text Add to dashboard Cite

Physicians experience high stress and have much responsibility during a night shift, which contributes to increased sympathetic activity, the risk factor for renal disease. The risk for end-stage renal disease (ESRD) in physicians is still unclear. Therefore, we conducted a nationwide population-based cohort study to clarify this issue. Using Taiwan’s National Health Insurance Research Database, we identified 30,268 physicians and 60,536 individuals from the general population matched with a ratio of 1:2 by age and sex. All participants who had ESRD before 2006 and residents were excluded. ESRD risk between physicians and the general population and among physician subgroups was compared by following up their medical histories until 2012. We also compared the treatments between both cohorts with ESRD. Physicians had a lower ESRD risk than the general population (adjusted odds ratio (AOR): 0.5; 95% confidence interval (CI): 0.4–0.7), particularly in the middle-age subgroup (35–64 years) (AOR: 0.4; 95% CI: 0.3–0.7); however, there was no difference in the older age subgroup (≥65 years) (AOR: 1.0; 95% CI: 0.6–1.7). More physicians received peritoneal dialysis (63.0% vs. 11.1%) and renal transplantation (5.6% vs. 1.7%) than the general population after being diagnosed with ESRD. Compared with the general population, physicians had a lower ESRD risk and higher treatment selection for peritoneal dialysis and renal transplantation after being diagnosed with ESRD. Better medical knowledge, a greater awareness of diseases and their risk factors, more rigorous implementation of preventive measures, and easy access to medical care may play a role in this aspect. Further studies are warranted for elucidating the associated mechanisms.

show abstract

Occupational risk and chronic kidney disease: a population-based study in the United States adult population

Cited by 13 publications

References 24 publications

Local Renal Circadian Clocks Control Fluid–Electrolyte Homeostasis and BP

Local Renal Circadian Clocks Control Fluid–Electrolyte Homeostasis and BP

Perbandingan Kadar Ureum dan Kreatinin Serum Masyarakat Terpapar dengan Tidak Terpapar Emisi Pabrik PT. Semen Padang

Comparison of Risk for End-Stage Renal Disease Between Physicians and the General Population: A Nationwide Population-Based Cohort Study

Contact Info

Product

Resources

About