Occupational Risk for Hepatitis A and Hepatitis E among Health Care Professionals?

Nübling, Matthias; Hofmann, Friedrich; Tiller, Friedrich-Wilhelm

doi:10.1007/s15010-002-2023-3

Cited by 20 publications

(8 citation statements)

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“…While Trautwein et al [33] determined an overall seroprevalence of anti-HEV-IgG of 2.05% in German immigrants from the former UDSSR in 1995, in 1997 Jänisch et al [34] found 5.2% of long-term expatriates to be positive to anti-HEV-IgG and Nübling et al [35] investigated a rate of seropositivity to anti-HEV-IgG of 3.9 in 2002; our rate of seropositivity to anti-HEV-IgG exceeds this value nearly three times over. Whether the rising incidence is based on heightened clinical awareness and more frequent testing of possible cases or is caused by a real increase in the number of infections remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis E: are psychiatric patients on special risk?

Reinheimer

Allwinn

Berger

2011

Med Microbiol Immunol

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Hepatitis E virus (HEV) is largely confined to travelers returning from endemic areas, but the number of autochthonous cases of acute HEV infections in developed countries is increasing. Reservoirs for HEV are surface water, wild boar meat, and raw or undercooked pork meat. Usually, hepatitis E is a self-limiting disease presenting with acute hepatitis as a major clinical symptom. The seroprevalence of anti-HEV-IgG was investigated in 833 serum samples routinely collected from patients admitted to the university hospital in Frankfurt a. M., Germany (FFM) between 01.06.2008 and 31.12.2010. After determination of overall seroprevalence, we tested serum samples from patients diagnosed with acute elevation of liver enzymes (AELE), psychiatric (PSYCH), infectiological patients and serum samples from the red-cross blood donor service in FFM for anti-HEV-IgG using an ELISA. Between 01.06.2008 and 31.12.2010, 833 serum samples were analyzed for anti-HEV-IgG using an ELISA. We observed an overall seroprevalence of anti-HEV-IgG of 11.2% (95%CI: 9.6-13.2). Significantly higher rate of seropositivity was found in the group of PSYCH (26.0%; 95%CI: 14.63-40.34) and AELE (30.0%; 95%CI: 17.86-44.61). Overall seroprevalence of anti-HEV-IgG in FFM is higher than in Germany on average. The group of AELE and PSYCH shows significantly more often marker of HEV infections than other groups in our collective.

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Section: Discussionmentioning

confidence: 99%

Hepatitis E: are psychiatric patients on special risk?

Reinheimer

Allwinn

Berger

2011

Med Microbiol Immunol

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“…However, haemodialysis patients in four different studies [57,[96][97][98], those who had undergone minor surgery and abdominal surgery in Spain [4], healthcare workers in emergency admission and surgery in Germany [99] and male prisoners and drug treatment patients in Denmark [56] were found to have a higher anti-HEV IgG prevalence than the reference group.…”

Section: Potential For Parenteral Transmissionmentioning

confidence: 99%

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

2009

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SUMMARYIncreasing numbers of non-travel-associated hepatitis E virus (HEV) infections have been reported in Europe in recent years. Our objective was to review the evidence on risk factors and transmission routes of autochthonous HEV infection and hepatitis E in Europe in order to develop recommendations for future research, prevention and control. A systematic literature review was performed to identify all primary reports and studies published during 1998-2008 on hepatitis E in humans and animals in Europe by searching Pubmed, reference lists of major articles and international conference proceedings. Each of the 106 included studies was categorized into one of three evidence levels (EL) based on study design and diagnostic methodology. The evidence was generally weak (73 were assigned to EL1, two to both EL1 and EL2, and 30 to EL2), further compounded by the use of poorly validated serological assays in some studies. Only one casecontrol study was assigned to EL3. Persons with autochthonous hepatitis E infection were on average older than the general population and predominantly male. There was no evidence for one main transmission route of HEV infection or risk factor for hepatitis E. However, zoonotic transmission seemed likely and person-to-person transmission too inefficient to cause clinical disease. Multiple routes of transmission probably exist and should be further investigated through analytical studies and reliable diagnostic kits. Based on current evidence that points to zoonotic transmission from pigs, thorough cooking of all porcine products, prevention of crosscontamination in the kitchen and improved education for occupationally exposed people (e.g. pig farmers, veterinarians and sewage workers) may help prevent HEV infection. Although evidence for parenteral transmission is limited, it is recommended that a risk assessment is undertaken.

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“…Seroprevalence of hepatitis A virus antibody among healthcare workers[32][33][34][35][36][37][38][39][40][41][42][43][44][45][47][48][49][50] …”

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confidence: 99%

The risk of hepatitis A infection among healthcare workers: a review of reported outbreaks and sero-epidemiologic studies

Chodick

Ashkenazi

Lerman

2006

Journal of Hospital Infection

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Occupational Risk for Hepatitis A and Hepatitis E among Health Care Professionals?

Abstract: Specific departments of health care show higher prevalence of anti-HAV or anti-HEV. In the case of HEV further studies in the exposed working field are needed. Since no connection between the two serological results was found, transmission mechanisms might be (partly) different.

Cited by 20 publications

References 20 publications

Hepatitis E: are psychiatric patients on special risk?

Hepatitis E: are psychiatric patients on special risk?

Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review

The risk of hepatitis A infection among healthcare workers: a review of reported outbreaks and sero-epidemiologic studies

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