Occupational risks for the development of brain tumors

Kaplan, Sara; Etlin, Shimon; Novikov, Ilya; Modan, Baruch

doi:10.1002/(sici)1097-0274(199701)31:1<15::aid-ajim3>3.0.co;2-w

Cited by 17 publications

(16 citation statements)

References 16 publications

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“…13,29 Only a few studies are available on occupational factors of brain cancer among women. Increased risk has been reported among women employed in textile industry 30,31 and among the males employed in the weaving and spinning departments in Poland. 13 It should be noted that the increased incidence of brain cancer was recorded among the women employed in the weaving and spinning departments in Alytus factory.…”

Section: Discussionmentioning

confidence: 99%

Cancer Incidence in the Workers Cohort of Textile Manufacturing Factory in Alytus, Lithuania

Kuzmickienė

Didžiapetris

Stukonis

2004

Journal of Occupational and Environmental Medicine

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Altogether 14,650 workers employed at least for 1 year a the textile factory in Alytus, Lithuania, were included in the cohort and followed during the period from 1978 to 1997. The standardized incidence ratio (SIR) for men was 1.28. The incidence of esophagus cancer was significant higher (SIR 3.42). It increased only slightly for lung (SIR 1.35). In the women cohort, SIR was 1.05. However, there was a significant increase of the incidence of gallbladder cancer (SIR 3.19). Among textile-processing (spinning and weaving departments) women workers, we found elevated total cancer incidence (SIR 1.35), incidence of breast cancer (SIR 1.49), and cervical cancer (SIR 1.82). In this cohort increased SIR values were observed for more than 10 years since first exposure for all cancer (SIR 1.70) and cervical cancer (SIR 2.44).

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Section: Discussionmentioning

confidence: 99%

Cancer Incidence in the Workers Cohort of Textile Manufacturing Factory in Alytus, Lithuania

Kuzmickienė

Didžiapetris

Stukonis

2004

Journal of Occupational and Environmental Medicine

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“…Vinyl chloride, polyurethane, polystyrene and polyethylene used as monomer and polymer substances in the plastic industry are also very important in the NSC etiology 6,27 . Several authors have shown that the carcinogenic agents such as: high molecular weight aliphatic hydrocarbons (gasoline, diesel oil), aromatic hydrocarbons, polycyclic aromatic hydrocarbons (PAH) and polychlorinated biphenyl, increase the risk of NSC in populational groups submitted to occupational exposure (drivers, heavy-vehicle operators) and environmental pollution 6,7,31,32 .…”

Section: Discussionmentioning

confidence: 99%

“…This fact has been attributed to the improvement in diagnostic techniques 6,10,28 and exposure to carcinogenic factors 6,7,29 . Among these, urbanization, industrialization, socioeconomic conditions, lifestyles and occupational exposure have been cited 11,25,37 .…”

Section: Discussionmentioning

confidence: 99%

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Nervous system cancer mortality in an industrialized area of Brazil 1980 - 1993

Medrado-Faria

Almeida

Zanetta

et al. 2000

Arq. Neuro-Psiquiatr.

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-Objectives:The industrialization process and nervous system cancer (NSC) mortality in a urban region of Brazil. Method: From registries of the State System of Data Analysis Foundation (SEADE), 103 males deaths by NSC (ICD-9) in Baixada Santista (BS), from 1980 to 1993 were selected. Mortality ratios were calculated comparing the standardized mortality rate for ages over 10 years old (G1) and for the age group from 35 to 64 years old, in the industrialized and non-industrialized areas in three periods : 1980-1993, 1980-86, 1987-93. Results: A statiscally significant high mortality was observed in the industrialized area, for ages over 10 in all periods and only from 1980 to 1993 for ages from 34 to 64. The highest mortality ratio occurred from 1980-86 for ages over 10 -4.12 (CI 1.79-9.42). Conclusion: High mortality was probably related to the environmental and occupational exposure to many organic and inorganic chemical substances, considered carcinogenics, such as aliphatic and aromatic hydrocarbons, organochlorinated, formaldehyde, nitrogenated compounds and heavy metals, found in the port and industrial complex. We discuss the importance of case-control studies in characterizing the association of these and other risk factors in the determination of NSC.KEY WORDS: occupational cancer, cancer mortality, cancer epidemiology, nervous system cancer; brain cancer. Mortalidade por câncer do sistema nervoso em uma área industrializada do Brasil 1980-1993RESUMO -Objetivo: Estudar o processo de industrialização e a mortalidade por câncer do sistema nervoso (CSN) em uma região urbana do Brasil. Método: Foram selecionados dos registros das Fundação Sistema Estadual de Análise de Dados Estatísticos (SEADE), 103 óbitos por CSN (ICD-9) ocorridos na Baixada Santista, no sexo masculino acima dos 10 anos, de 1980 a 1993. Calcularam-se as razões de mortalidade, padronizadas por idade, comparando as áreas industrializada e não industrializada, nos períodos de 1980-93, 1980-96 e 1987-93. Resultados: Observou-se excesso significante de mortalidade na área industrializada para a população acima de 10 anos, em todos os períodos -3.11 ) e 2.63 . Para o grupo de 35-64 anos o excesso ocorreu apenas no período de 1980-93 -2.46 (CI 1.20-5.11). Conclusão: Supõe-se que esse excesso relaciona-se à exposição ocupacional e ambiental a carcinogênicos presentes no complexo industrialportuário como: hidrocarbonetos aromáticos, órgano-clorados, compostos nitrogenados e metais. Estudos casocontrole são necessários para o estudo desses e de outros fatores de risco na determinação do CSN. PALAVRAS-CHAVE: câncer ocupacional, mortalidade por câncer, epidemiologia do câncer, câncer do sistema nervoso.

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“…With the exception of familial cancer syndromes (Li-Fraumeni) involving the nervous system and irradiation, the etiology of brain tumors is still largely unknown (Kleihues and Cavenee, 2000). Epidemiological studies have shown that increased risk of brain tumor development is associated with certain occupations, such as farming, dentistry, fire fighting, metal works, and the rubber industry, but specific exposures or causative environmental agents have not been identified (Thomas et al, 1986;Kaplan et al, 1997). Malignant glioma is the most common primary malignant brain tumor in adults, while neuroblastoma, a tumor of the postganglionic sympathetic nervous system, is the most common extracranial solid tumor of children (DeAngelis, 2001).…”

Section: Introductionmentioning

confidence: 99%

Genetic Alterations in Brain Tumors Following 1,3-Butadiene Exposure in B6C3F1 Mice

Kim

Hong

Lachat³

et al. 2005

Toxicol Pathol

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The nervous system of the B6C3F1 mouse has rarely been a target for chemical carcinogenesis in the National Toxicology Program (NTP) bioassays. However, 6 malignant gliomas and 2 neuroblastomas were observed in B6C3F1 mice exposed to 625 ppm 1,3-butadiene (NTP technical reports 288 and 434). These mouse brain tumors were evaluated with regard to the profile of genetic alterations that are observed in human brain tumors. Alterations in the p53 tumor suppressor gene were common. Missense mutations were observed in 3/6 malignant gliomas and 2/2 neuroblastomas and were associated with loss of heterozygosity. Most of the mutations occurred in exons 5-8 of the p53 gene and were G → A transitions, and did not involve CpG sites. Loss of heterozygosity at the Ink4a/Arf gene locus was observed in 5/5 malignant gliomas and 1/1 neuroblastoma, while the PTEN (phosphatase and tensin homologue) gene locus was unaffected by deletions. One of 2 neuroblastomas had a mutation in codon 61 of H-ras, while H-ras mutations were not observed in the malignant gliomas examined. Only 1 brain tumor has been reported from control mice of over 500 NTP studies. This malignant glioma showed no evidence of alterations in the p53 gene or K -and H-ras mutations. It is likely that the specific genetic alterations observed were induced or selected for by 1,3-butadiene treatment that contributed to the development of mouse brain tumors. The observed findings are similar in part to the genetic alterations reported in human brain tumors.

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Occupational risks for the development of brain tumors

Cited by 17 publications

References 16 publications

Cancer Incidence in the Workers Cohort of Textile Manufacturing Factory in Alytus, Lithuania

Cancer Incidence in the Workers Cohort of Textile Manufacturing Factory in Alytus, Lithuania

Nervous system cancer mortality in an industrialized area of Brazil 1980 - 1993

Genetic Alterations in Brain Tumors Following 1,3-Butadiene Exposure in B6C3F1 Mice

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