Background: Driving buses exposes the drivers to many stressors that can increase their cardiovascular risk factors. Aims: The objective of this study was to measure the prevalence of workplace stress and its association with cardiovascular risk factors among bus drivers in Egypt. Methods: A cross-sectional study was conducted on 234 bus drivers in Cairo, Egypt. Data were collected over a period of 6 months from August 2016 to January 2017. For all drivers, blood pressure, body weight and height and random blood sugar were measured. Professional driving duration/age ratio was calculated. Comparison between cardiovascular risk factors and workplace stress score was made. Unadjusted and adjusted odds ratios and 95% confidence intervals were calculated using logistic regression models. Results: A high prevalence of workplace stress (83.3%) was observed among bus drivers. Moreover, a high prevalence of cardiovascular risk factors, particularly tobacco smoking (65.0%), physical inactivity (93.6%) and hypertension (33.3%), was noted. After adjustment for age and other confounding factors, the risk factors associated with workplace stress were overweight/obesity and hypertension. Conclusions: There is a positive association between workplace stress and some cardiovascular risk factors, such as hypertension and overweight/obesity, among bus drivers in Egypt.