Occupational variation in incidence of oropharyngeal cancer in the Nordic countries

Mroueh, Rayan; Mäkitie, Antti; Carpén, Timo; Hansen, Johnni; Heikkinen, Sanna; Lynge, Elsebeth; Selander, Jenny; Mehlum, Ingrid Sivesind; Torfadóttir, Jóhanna E.; Salo, Tuula; Pukkala, Eero

doi:10.1007/s00405-023-08168-6

Cited by 2 publications

(3 citation statements)

References 44 publications

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“…Notwithstanding the absence of clearly defined associations between occupational exposures and OPC, there are indications suggesting an increased risk in a few professional groups, such as waiters, cooks and stewards, artistic workers, poultry, meat, and soup manufacturing workers, mechanics, construction industry workers, and WTC responders exposed to dust after the September 11 attacks [5,27,[29][30][31]34]. The increased incidence of OPC in waiters may be due to exposure to environmental tobacco smoking, i.e., passive smoking, which in conjunction with their own smoking habits and alcohol consumption might explain the six-fold risk of OPC in this occupational group [14,51]. Exposure to cooking fumes may also have contributed to the excess risk of OPC observed, not only in male cooks and stewards but also in waiters and waitresses.…”

Section: Discussionmentioning

confidence: 99%

“…The study by Nikkilä et al [14] revealed a high excess risk of OPC among Nordic male artistic workers (SIR = 2.97, 95% CI: 2.31-3.76), seamen (SIR = 2.30, 95% CI: 1.91-2.77), and journalists (SIR = 2.09, 95% CI: 1.33-3.14). Among Nordic women, a statistically significant excess risk of OPC was observed in packers, loaders, and warehouse workers (SIR = 1.73, 95% CI: 1.07-2.64).…”

Section: Other Occupational Categoriesmentioning

confidence: 98%

“…The study by Nikkilä et al [14] conveyed an elevated incidence of OPC for male waiters (standardized incidence ratio (SIR) = 6.28, 95% CI: 4.68-8.26) and cooks and stewards (SIR 2.64, 95% CI: 1.83-3.69) when compared to the respective country-, age-, sex-, and calendar-period-specific incidence rates in the general population. A statistically significant excess risk of OPC was also observed in female waiters (SIR = 2.02, 95% CI: 1.41-2.81).…”

Section: Hospitality Industrymentioning

confidence: 99%

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Occupational Etiology of Oropharyngeal Cancer: A Literature Review

Nikkilä,

Tolonen,

Salo

et al. 2023

IJERPH

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While abundant evidence exists linking alcohol, tobacco, and HPV infection to a carcinogenic impact on the oropharynx, the contribution of inhalational workplace hazards remains ill-defined. We aim to determine whether the literature reveals occupational environments at a higher-than-average risk of developing oropharyngeal cancer (OPC) and summarize the available data. To identify studies assessing the relationship between occupational exposure and risk of OPC, a search of the literature through the PubMed-NCBI database was carried out and, ultimately, 15 original articles meeting eligibility criteria were selected. Only original articles in English focusing on the association between occupational exposure and risk or death of specifically OPC were included. The available data are supportive of a potentially increased risk of OPC in waiters, cooks and stewards, artistic workers, poultry and meat workers, mechanics, and World Trade Center responders exposed to dust. However, the available literature on occupation-related OPC is limited. To identify occupational categories at risk, large cohorts with long follow-ups are needed. Identification of causal associations with occupation-related factors would require dose–response analyses adequately adjusted for confounders.

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Section: Discussionmentioning

confidence: 99%

Section: Other Occupational Categoriesmentioning

confidence: 98%

Section: Hospitality Industrymentioning

confidence: 99%

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Occupational Etiology of Oropharyngeal Cancer: A Literature Review

Nikkilä,

Tolonen,

Salo

et al. 2023

IJERPH

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Second primary cancers in patients with a pharyngeal index tumour: a register-based cohort study

Nikkilä,

Hirvonen,

Haapaniemi

et al. 2024

BMC Cancer

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Background While prior research on the SPC (second primary cancer) risk among pharyngeal carcinoma (PC) patients has been conducted in other regions, the European perspective is underrepresented. Our register-based cohort study aims to assess the subsite-specific risk of SPC among individuals initially diagnosed with a pharyngeal index tumour. Methods Standardized incidence ratios (SIR) of SPC were calculated relative to the general population for all patients diagnosed with a primary oropharyngeal, nasopharyngeal, and hypopharyngeal carcinoma (OPC, NPC, and HPC) in Finland during 1953–2021. Results A total of 4701 PC patients – 3320 men (71%) and 1381 women (29%) – were identified. The average and median follow-up times were 5.7 and 2.8 years, respectively. A SPC was diagnosed in 561 patients (11.9%): in 12.3% of men (n = 410) and 10.9% of women (n = 151). For male PC patients, the overall SIR for an SPC at any primary site was 1.83 (95% CI: 1.65–2.01). For female patients, the corresponding SIR was 1.89 (95% CI: 1.60–2.22). OPC and HPC showed increased risks for SPCs of the mouth/pharynx (SIR 4.41 and 6.91, respectively) and respiratory organs (SIR 3.51 and 4.80). OPC patients also had an increased risk in digestive organs (SIR 1.83). Male NPC patients exhibited increased risks for oral/pharyngeal, brain, and haematolymphoid SPCs (SIRs 5.14, 6.60, and 3.05, respectively). Conclusion PC patients face an 80% higher SPC risk, which persists decades after treatment. Healthcare professionals must be aware of this, providing counselling and encouraging a healthy lifestyle, including smoking cessation, while monitoring symptoms.

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Occupational variation in incidence of oropharyngeal cancer in the Nordic countries

Cited by 2 publications

References 44 publications

Occupational Etiology of Oropharyngeal Cancer: A Literature Review

Occupational Etiology of Oropharyngeal Cancer: A Literature Review

Second primary cancers in patients with a pharyngeal index tumour: a register-based cohort study

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