Occupations associated with COPD risk in the large population-based UK Biobank cohort study

Matteis, Sara De; Jarvis, Déborah; Hutchings, Sally; Darnton, Andy; Fishwick, David; Sadhra, Steven; Rushton, Lesley; Cullinan, Paul

doi:10.1136/oemed-2015-103406

Cited by 70 publications

(64 citation statements)

References 23 publications

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“…[8][9][10][11] Biological dusts were included in other COPD JEMs, but this JEM evaluated biological dusts through organic dust and sensitisers. 8 The JEM approach is limited because it does not account for exposure variability within the same job across industries.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposures and chronic obstructive pulmonary disease (COPD): comparison of a COPD-specific job exposure matrix and expert-evaluated occupational exposures

2016

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Objectives To compare the occupational exposure levels assigned by our National Institute for Occupational Safety and Health chronic obstructive pulmonary disease-specific job exposure matrix (NIOSH COPD JEM) and by expert evaluation of detailed occupational information for various jobs held by members of an integrated health plan in the Northwest USA. Methods We analysed data from a prior study examining COPD and occupational exposures. Jobs were assigned exposure levels using 2 methods: (1) the COPD JEM and (2) expert evaluation. Agreement (Cohen’s κ coefficients), sensitivity and specificity were calculated to compare exposure levels assigned by the 2 methods for 8 exposure categories. Results κ indicated slight to moderate agreement (0.19–0.51) between the 2 methods and was highest for organic dust and overall exposure. Sensitivity of the matrix ranged from 33.9% to 68.5% and was highest for sensitisers, diesel exhaust and overall exposure. Specificity ranged from 74.7% to 97.1% and was highest for fumes, organic dust and mineral dust. Conclusions This COPD JEM was compared with exposures assigned by experts and offers a generalisable approach to assigning occupational exposure.

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Section: Discussionmentioning

confidence: 99%

Occupational exposures and chronic obstructive pulmonary disease (COPD): comparison of a COPD-specific job exposure matrix and expert-evaluated occupational exposures

2016

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“…In a set of sensitivity analyses, we further examined the sex difference in the effect of increasing number of pack-years among current smokers by: 1) adjusting for the top 14 jobs identified as those with moderate/high airflow obstruction increased risk (18); 2) excluding participants with self-reported doctor-diagnosed asthma; 3) excluding non-Caucasians; and 4) excluding Caucasians. In addition, we assessed whether the decline in the FEV1/FVC ratio (continuous) and FEV1 (continuous), as proxies for severity, associated with pack-years was different between women and men among current smokers with airflow obstruction.…”

Section: Discussionmentioning

confidence: 99%

Female Smokers Are at Greater Risk of Airflow Obstruction Than Male Smokers. UK Biobank

Amaral

Strachan

Burney

et al. 2017

Am J Respir Crit Care Med

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“…23 Some of the specific occupations that have been associated with the development of COPD include smelter workers, machine operators, cleaners, coalminers, cotton workers, construction workers and bus drivers. [24][25][26]…”

Section: Discussionmentioning

confidence: 99%

Occupational lung diseases in Australia

Hoy

Brims²

2017

Medical Journal of Australia

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Occupational exposures are an important determinant of respiratory health. International estimates note that about 15% of adult-onset asthma, 15% of chronic obstructive pulmonary disease and 10-30% of lung cancer may be attributable to hazardous occupational exposures. One-quarter of working asthmatics either have had their asthma caused by work or adversely affected by workplace conditions. Recently, cases of historical occupational lung diseases have been noted to occur with new exposures, such as cases of silicosis in workers fabricating kitchen benchtops from artificial stone products. Identification of an occupational cause of a lung disease can be difficult and requires maintaining a high index of suspicion. When an occupational lung disease is identified, this may facilitate a cure and help to protect coworkers. Currently, very little information is collected regarding actual cases of occupational lung diseases in Australia. Most assumptions about many occupational lung diseases are based on extrapolation from overseas data. This lack of information is a major impediment to development of targeted interventions and timely identification of new hazardous exposures. All employers, governments and health care providers in Australia have a responsibility to ensure that the highest possible standards are in place to protect workers' respiratory health.

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Occupations associated with COPD risk in the large population-based UK Biobank cohort study

Abstract: Selected occupations are associated with increased COPD risk in a large cross-sectional population-based UK study. Further analyses should confirm the extent to which these associations reflect exposures still of concern and where strengthened preventive action may be needed.

Cited by 70 publications

References 23 publications

Occupational exposures and chronic obstructive pulmonary disease (COPD): comparison of a COPD-specific job exposure matrix and expert-evaluated occupational exposures

Occupational exposures and chronic obstructive pulmonary disease (COPD): comparison of a COPD-specific job exposure matrix and expert-evaluated occupational exposures

Female Smokers Are at Greater Risk of Airflow Obstruction Than Male Smokers. UK Biobank

Occupational lung diseases in Australia

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