Occurrence and ecological risk of pharmaceuticals in river surface water of Bangladesh

Hossain, Anwar; Nakamichi, Shihori; Habibullah-Al-Mamun, Md.; Tani, Keiichiro; Masunaga, Shigeki; Matsuda, Hiroyuki

doi:10.1016/j.envres.2018.04.030

Cited by 136 publications

(58 citation statements)

References 43 publications

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“…In many poorly studied parts of the world, APIs are openly available without a prescription and prone to miss-/over-use so concentrations might be expected to be greater than those reported so far [6]. Similarly, API disposal practices and inefficient wastewater connectivity and treatment may further exacerbate high API concentrations in some regions [1,6]. Underpinning such research are the complex analytical methods employed for specific quantification of APIs in water, namely High-Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS/MS).…”

Section: Introductionmentioning

confidence: 93%

“…For example, a complete or significant lack of knowledge exists for many parts of the world (e.g., Africa and South America) as such research disproportionally targets wealthy regions including North America, Western Europe and China [4,5]. In many poorly studied parts of the world, APIs are openly available without a prescription and prone to miss-/over-use so concentrations might be expected to be greater than those reported so far [6]. Similarly, API disposal practices and inefficient wastewater connectivity and treatment may further exacerbate high API concentrations in some regions [1,6].…”

Section: Introductionmentioning

confidence: 99%

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A Novel Method to Characterise Levels of Pharmaceutical Pollution in Large-Scale Aquatic Monitoring Campaigns

2019

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Much of the current understanding of pharmaceutical pollution in the aquatic environment is based on research conducted in Europe, North America and other select high-income nations. One reason for this geographic disparity of data globally is the high cost and analytical intensity of the research, limiting accessibility to necessary equipment. To reduce the impact of such disparities, we present a novel method to support large-scale monitoring campaigns of pharmaceuticals at different geographical scales. The approach employs the use of a miniaturised sampling and shipping approach with a high throughput and fully validated direct-injection High-Performance Liquid Chromatography-Tandem Mass Spectrometry method for the quantification of 61 active pharmaceutical ingredients (APIs) and their metabolites in tap, surface, wastewater treatment plant (WWTP) influent and WWTP effluent water collected globally. A 7-day simulated shipping and sample stability assessment was undertaken demonstrating no significant degradation over the 1–3 days which is typical for global express shipping. Linearity (r2) was consistently ≥0.93 (median = 0.99 ± 0.02), relative standard deviation of intra- and inter-day repeatability and precision was <20% for 75% and 68% of the determinations made at three concentrations, respectively, and recovery from Liquid Chromatography Mass Spectrometry grade water, tap water, surface water and WWTP effluent were within an acceptable range of 60–130% for 87%, 76%, 77% and 63% of determination made at three concentrations respectively. Limits of detection and quantification were determined in all validated matrices and were consistently in the ng/L level needed for environmentally relevant API research. Independent validation of method results was obtained via an interlaboratory comparison of three surface-water samples and one WWTP effluent sample collected in North Liberty, Iowa (USA). Samples used for the interlaboratory validation were analysed at the University of York Centre of Excellence in Mass Spectrometry (York, UK) and the U.S. Geological Survey National Water Quality Laboratory in Denver (Colorado, USA). These results document the robustness of using this method on a global scale. Such application of this method would essentially eliminate the interlaboratory analytical variability typical of such large-scale datasets where multiple methods were used.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

A Novel Method to Characterise Levels of Pharmaceutical Pollution in Large-Scale Aquatic Monitoring Campaigns

2019

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“…The hospital and clinic waste treatment process in Bangladesh is very limited and most cases absent in rural area and consequently accumulated in surface and ground water. In Bangladesh formulated feeds and in some cases poultry droppings are used for aquaculture and those are enriched with pharmaceuticals [181] and accumulating in the water bodies. Huerta-Fontela [182] and coauthors found 55 commonly prescribed pharmaceuticals and hormones in raw water used for drinking water supply and 5 of them were unable to remove up to a reasonable limit via standard water treatment procedures.…”

Section: Pharmaceuticals Pollutionmentioning

confidence: 99%

“…A group reported that approximate 13 % of consumed carbamazepine is discharged from the body through excreta and urine without any substantial structural modification [183]. There are only few articles have been reported the pharmaceuticals (Table 7) in surface water in Bangladesh [181,184].…”

Section: Pharmaceuticals Pollutionmentioning

confidence: 99%

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Surface and Ground Water Pollution in Bangladesh: A Review

Sarkar

Rahman

Samad

et al. 2019

Asian Review of Environmental and Earth Sciences

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Environmental analysis does not become properly meaningful unless follow the standard procedure in sampling, preserving and also in analysis. This study investigates different studies on surface and groundwater pollution and discusses their findings along with impacts on environment, human health and aquatic ecosystem demolition. Fresh water is a vital need for drinking, household, agricultural and industrial use. Fresh water availability is shrinking worldwide due to imprudent use. Abound availability of fresh water in Bangladesh is now polluting due to unwise dumping of industrial, household, agricultural and municipal wastes. Water body in urban arena is severely polluted rather than rural part. The over concentration of DO, BOD, COD, EC, TDS, Cr, Cd, Pb was observed in Dhaka region. The highest arsenic concentration was found in the ground water of Lakshimpur. The main sources of pollution in industrial cities are anthropogenic sources like untreated industrial effluent and municipal wastes whereas in rural part the main sources of pollution are agricultural and naturogenic. Transboundary impact also intensifies some river water pollution. Government approved the policies, ordinance, acts and laws however, due to lack of proper implementation and monitoring water pollution problem increasing day by day.

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