Occurrence and ecotoxicological assessment of pharmaceuticals: Is there a risk for the Mediterranean aquatic environment?

Desbiolles, Fanny; Malleret, Laure; Tiliacos, Christophe; Wong-Wah-Chung, Pascal; Laffont-Schwob, Isabelle

doi:10.1016/j.scitotenv.2018.04.351

Cited by 240 publications

(87 citation statements)

References 86 publications

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“…Ecological risks of PPCPs in surface waters were assessed by use of a methodology developed within the NORMAN Association [33] and previous studies [8,[33][34][35][36]. Chronic, sublethal, risk quotients (RQ) were calculated by dividing measured concentration of individual chemicals in waters by the predicted no effect concentration (PNEC; Equation 1).…”

Section: Assessment Of Risksmentioning

confidence: 99%

“…Furthermore, to identify PPCPs of greatest concern in the two lakes a prioritization index (PI; Equation 2) was calculated, as the result of RQ max , calculated for the maximum concentration, multiplied by the frequency of PNEC exceedance (Equation 3). This index allows to smooth out the impact of compounds with high RQ but rarely detected [34]. (see…”

Section: Assessment Of Risksmentioning

confidence: 99%

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Occurrence and multiple-level ecological risk assessment of pharmaceuticals and personal care products (PPCPs) in two shallow lakes of China

Liu

Jin

Zheng

et al. 2020

Preprint

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Background: Management of pharmaceuticals and personal care products (PPCPs) in the environment has become a social issue. In the present study, concentrations of 140 PPCPs at 20 sites in Baiyangdian Lake and Tai Lake from 2016 to 2017 were analyzed by Ultra Performance Liquid Chromatography Mass Spectrometer (UPLC-MS). Risk quotients (RQ) were calculated for each detected chemical at all sites and prioritization indices (PI), based on maximum RQ, were calculated. To assess the risk of chemicals that identified high priority (PI>1), a more accurate method of joint probability curves (JPCs) was applied. Results: A total of 42 PPCPs were identified and quantified detected in the two lakes, with maximum concentrations ranged from 0.04 to 889 ng/L. Among these, seven PPCPs were identified as high or moderate risk pollutants for at least one site, 3 in Tai Lake and 5 in Baiyangdian Lake. Carbamazepine posed significant ecological risk at all 20 sites, such that more attention should be paid to that drug. Based on results of the JPCs, sulfamethoxazole, caffeine, diethyltoluamide, and carbamazepine were categorized as high or intermediate risks. Conclusion: Occurrences and distributions of PPCPs were different in the two lakes. Multiple-level risk assessment from simple to more complex was appropriate in chemical risk management.

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Section: Assessment Of Risksmentioning

confidence: 99%

Section: Assessment Of Risksmentioning

confidence: 99%

Occurrence and multiple-level ecological risk assessment of pharmaceuticals and personal care products (PPCPs) in two shallow lakes of China

Liu

Jin

Zheng

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Ecological risks caused by PPCPs in surface waters were assessed by use of a methodology developed within the NORMAN Association [33] and previous studies [8,[33][34][35][36]. Chronic, sublethal, risk quotients (RQ) were calculated by dividing measured concentration of individual chemicals in waters by the predicted no effect concentration (PNEC; Equation 1).…”

Section: Assessment Of Risksmentioning

confidence: 99%

Occurrence and multiple-level ecological risk assessment of pharmaceuticals and personal care products (PPCPs) in two lakes of China

Liu

Jin

Zheng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Management of pharmaceuticals and personal care products (PPCPs) in the environment has become a social problem. In the present study, concentrations of 140 PPCPs at 20 sites in Baiyangdian Lake and Tai Lake from 2016 to 2017 were analyzed by Ultra Performance Liquid Chromatography Mass Spectrometer (HPLC-MS). Risk quotients (RQ) were calculated for each detected chemical at all sites and a prioritization index (PI) based on maximum RQ was calculated. To assess the risk of chemicals that identified high priority (PI>1), a more accurate method of joint probability curves (JPCs) was applied. Results: A total of 41 PPCPs were quantitatively detected in the two lakes, with maximum concentrations ranging from 0.04 to 889 ng/L. Among these, seven PPCPs were identified as high or moderate risk pollutants for at least one site, 3 in Tai Lake and 5 in Baiyangdian Lake. Carbamazepine posed ecological risk at all 20 sites, to which more attention should be paid in the future. Based on results of the JPCs, sulfamethoxazole, caffeine, diethyltoluamide, and carbamazepine were categorized as high or intermediate risk. Conclusion: Occurrences and distributions of PPCPs were different in the two lakes. Multiple-level risk assessment from simple to more complex was appropriate in chemical risk management.

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“…Although the OMPs are typically found in low concentrations, these pollutants are continuously released into the aquatic environment with particular physicochemical properties, often recognized by undesirable properties in which they can exert harmful effects on the ecosystem and on human health . Some products are characterized as being pharmacologically active, resistant to degradation, and highly persistent in aqueous mediums posing a potential risk of toxicity when in the environment . The estrogenic chemicals can significantly interfere in the function of the endocrine system in wildlife and humans, associated with developmental and reproductive functions, particularly in aquatic organisms .…”

Section: Introductionmentioning

confidence: 99%

Predictive Computational Tools for Assessment of Ecotoxicological Activity of Organic Micropollutants in Various Water Sources in Brazil

Silva

Lorenzo

Lopes

et al. 2019

Molecular Informatics

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This paper is dedicated to Prof. Paola Gramatica on the occasion of her retirement.Abstract: The increase of chemical pollutants detected in different aquatic environments over the past few years has been in the focus of several studies related to their occurrence, transport, fate, and hazards, or risks to human and environmental health. In Brazil, recent studies have been conducted on the occurrence of a series of organic micropollutants (OMPs) in aquatic environments. Nevertheless, the toxicological information and environmental behavior for most of these pollutants are still difficult to evaluate. We obtained consensus models using a combina-tion of VolSurf and Dragon descriptors and Random Forest approach to predict the toxicity against Daphnia magna and Pimephales promelas for compounds identified in different sources of water in Brazil. The models showed satisfactory performance when compared with other approaches, such as Toxicity Estimation Software Tool (T.E.S.T.), etc. Both models can be used as complementary tools to aid in the prediction of organic compounds against both organisms.

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Occurrence and ecotoxicological assessment of pharmaceuticals: Is there a risk for the Mediterranean aquatic environment?

Cited by 240 publications

References 86 publications

Occurrence and multiple-level ecological risk assessment of pharmaceuticals and personal care products (PPCPs) in two shallow lakes of China

Occurrence and multiple-level ecological risk assessment of pharmaceuticals and personal care products (PPCPs) in two shallow lakes of China

Occurrence and multiple-level ecological risk assessment of pharmaceuticals and personal care products (PPCPs) in two lakes of China

Predictive Computational Tools for Assessment of Ecotoxicological Activity of Organic Micropollutants in Various Water Sources in Brazil

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