Occurrence and estrogenic activity of steroid hormones in Chinese streams: A nationwide study based on a combination of chemical and biological tools

Yao, Bo; Li, Rui; Yan, Shuwen; Chan, Shen-An; Song, Weihua

doi:10.1016/j.envint.2018.05.026

Cited by 65 publications

(21 citation statements)

References 53 publications

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“…This eastern coastal areas. 8,52 The spatial distribution pattern is similar with that described in this study. They measured four of the APIs modelled in this study, which exhibited 0-3 orders of magnitude lower median concentrations compared to Sc3 in this study, i.e.…”

Section: Dilution Factors Wastewater Discharge Flows and Wastewater supporting

confidence: 86%

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Spatially Explicit Large-Scale Environmental Risk Assessment of Pharmaceuticals in Surface Water in China

Zhu

Snape

Jones

et al. 2019

Environ. Sci. Technol.

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With improving health care and an aging population, the consumption of human pharmaceuticals in China has been increasing dramatically. Environmental risks posed by many active pharmaceutical ingredients (APIs) are still unknown. This study used a spatially-explicit dilution-factor methodology to model predicted environmental concentrations (PECs) of 11 human-use APIs in surface water for a preliminary environmental risk assessment (ERA). Median PECs in surface water across China range between 0.01-8.0×10 3 ng/L for the different APIs, under a moderate patient use scenario. Higher environmental risks of APIs in surface water are in regions with high water stress, e.g. northern China. Levonorgestrel, estradiol, ethinyl estradiol and abiraterone acetate were predicted to potentially pose a high or moderate environmental risk in China if consumption levels reach those in Europe. Relative risks of these four APIs have the potential to be amongst those chemicals with the highest impact on surface water in China when compared to the risks associated with other regulated chemicals, including triclosan and some standard water quality parameters including BOD5 (5-day biological oxygen demand), COD (chemical oxygen demand), Cu, Zn and Hg and linear alkylbenzene sulphonate. This method could support the regulation of this category of chemicals and risk mitigation strategies in China.

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Section: Dilution Factors Wastewater Discharge Flows and Wastewater supporting

confidence: 86%

“…E2 (median, 0.26 ng/L), MET (170 ng/L), DCF (3.1 ng/L) and IBPF (7.9 ng/L). 8,52 The most likely reason for this would be that expected higher future consumption levels were applied in this study.…”

Section: Dilution Factors Wastewater Discharge Flows and Wastewater mentioning

confidence: 99%

Spatially Explicit Large-Scale Environmental Risk Assessment of Pharmaceuticals in Surface Water in China

Zhu

Snape

Jones

et al. 2019

Environ. Sci. Technol.

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“…The rationale for using this selection process was that it would allow capturing the range of intersex within smallmouth bass populations based on the assumption that surface water estrogenicity was predictive of intersex prevalence and severity. The application of in vitro bioassay screening has led to an unprecedented attribution of biological potential ascribed to surface water samples during recent years [5,9,[39][40][41][42]. In the absence or in conjunction with analytical chemistry, such datasets have provided biological-proxy data without the need to sacrifice resident biota and have the potential to inform predictive modelling to guide biological sampling site selection [43].…”

Section: Discussionmentioning

confidence: 99%

Reconnaissance of Surface Water Estrogenicity and the Prevalence of Intersex in Smallmouth Bass (Micropterus Dolomieu) Inhabiting New Jersey

Iwanowicz

Smalling

Blazer

et al. 2020

IJERPH

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The observation of testicular oocytes in male fishes has been utilized as a biomarker of estrogenic endocrine disruption. A reconnaissance project led in the Northeastern United States (US) during the period of 2008-2010 identified a high prevalence of intersex smallmouth bass on or near US Fish & Wildlife Service National Wildlife Refuges that included the observation of 100% prevalence in smallmouth bass males collected from the Wallkill River, NJ, USA. To better assess the prevalence of intersex smallmouth bass across the state of New Jersey, a tiered reconnaissance approach was initiated during the fall of 2016. Surface water samples were collected from 101 (85 river, 16 lake/reservoir) sites across the state at base-flow conditions for estrogenicity bioassay screening. Detectable estrogenicity was observed at 90% of the sites and 64% were above the US Environmental Protection Agency trigger level of 1 ng/L. Median surface water estrogenicity was 1.8 ng/L and a maximum of 6.9 ng/L E2Eq BLYES was observed. Adult smallmouth bass were collected from nine sites, pre-spawn during the spring of 2017. Intersex was identified in fish at all sites, and the composite intersex prevalence was 93.8%. Prevalence across sites ranged from 70.6% to 100%. In addition to intersex, there was detectable plasma vitellogenin in males at all sites. Total estrogenicity in surface water was determined at these fish collection sites, and notable change over time was observed. Correlation analysis indicated significant positive correlations between land use (altered land; urban + agriculture) and surface water estrogenicity. There were no clear associations between land use and organismal metrics of estrogenic endocrine disruption (intersex or vitellogenin). This work establishes a baseline prevalence of intersex in male smallmouth bass in the state of New Jersey at a limited number of locations and identifies a number of waterbodies with estrogenic activity above an effects-based threshold.on results from discrete grab surface water samples (methods below), in combination with land-use gradients, spatial distributions and the availability of viable fish populations, we identified 9 sites for the collection of smallmouth bass. These locations included reservoirs, lakes and sites along the Delaware River. For more information on sampling locations, see [31]. Int. J. Environ. Res. Public Health 2020, 17, x 3 of 17 9 sites for the collection of smallmouth bass. These locations included reservoirs, lakes and sites along the Delaware River. For more information on sampling locations, see [31].

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“…11 Residues of these estrogens are often found in aquatic matrices worldwide, such as surface water, groundwater and even potable water. 1,4,12,13 In Brazil, these compounds have already been found in concentrations above 1000 ng L −1 , 3,14,15 ranging from 0.09-11 130 ng L −1 in different aqueous matrices. 12 Despite the risk posed by these substances, there is still no legislation to limit their release into the environment.…”

Section: Introductionmentioning

confidence: 98%

“…So-called contaminants of emerging concern have been detected in environmental matrices in different parts of the world in concentrations of ng L −1 to μg L −1 , causing harmful effects to the environment, biota and humans. [1][2][3][4][5] Some of these substances are referred to as endocrine disruptors since they have the capacity to alter the function of the endocrine system, interfering with the metabolism and causing reproductive disorders and increased breast cancer potential in different organisms. 6,7 The natural estrogens estrone (E1) and 17 -estradiol (E2) and the synthetic estrogen 17 -ethynylestradiol (EE2) are contaminants that may trigger a number of effects when in the environment, such as the feminization of fish, 8,9 early menopause in women 2 and increase in the incidence of cancer, 10 imposing a great risk to humans, soils, plants and water resources.…”

Section: Introductionmentioning

confidence: 99%

Application of a stable Ag/TiO₂ film in the simultaneous photodegradation of hormones

Lima

Emídio

Nogueira

et al. 2019

J of Chemical Tech & Biotech

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BACKGROUND The natural hormones estrone (E1) and 17β‐estradiol (E2) and the synthetic hormone 17α‐ethynylestradiol (EE2) are excreted daily by humans and may reach water and wastewater treatment plants, which do not efficiently remove these estrogens. The aim of the present study was to evaluate the efficiency and reusability of Ag/TiO2 films as catalysts for simultaneous degradation of the hormones E1, E2 and EE2 in aqueous medium by heterogeneous photocatalysis and the contribution of reactive oxygenated species. The influence of aeration on the system and the effects of estrogen concentration and Ag/TiO2 film area were also evaluated in the photodegradation process. RESULTS The photocatalytic degradation assays showed efficiency higher than 97% for E2 and EE2 (10 μg L−1) after approximately 3.5 h and above 95% for E1 (100 μg L−1) after 4.5 h. It was observed that hydroxyl radical is the main reactive oxidant species in the photodegradation process, responsible for 87, 86 and 79% degradation of E1, E2 and EE2 respectively. CONCLUSION The treatment process applied using the Ag/TiO2 films proved to be very stable and efficient for the simultaneous degradation of the studied hormones up to 305 h of reaction period, obtaining a percentage of degradation above 90%. © 2019 Society of Chemical Industry

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Occurrence and estrogenic activity of steroid hormones in Chinese streams: A nationwide study based on a combination of chemical and biological tools

Cited by 65 publications

References 53 publications

Spatially Explicit Large-Scale Environmental Risk Assessment of Pharmaceuticals in Surface Water in China

Spatially Explicit Large-Scale Environmental Risk Assessment of Pharmaceuticals in Surface Water in China

Reconnaissance of Surface Water Estrogenicity and the Prevalence of Intersex in Smallmouth Bass (Micropterus Dolomieu) Inhabiting New Jersey

Application of a stable Ag/TiO₂ film in the simultaneous photodegradation of hormones

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Occurrence and estrogenic activity of steroid hormones in Chinese streams: A nationwide study based on a combination of chemical and biological tools

Cited by 65 publications

References 53 publications

Spatially Explicit Large-Scale Environmental Risk Assessment of Pharmaceuticals in Surface Water in China

Spatially Explicit Large-Scale Environmental Risk Assessment of Pharmaceuticals in Surface Water in China

Reconnaissance of Surface Water Estrogenicity and the Prevalence of Intersex in Smallmouth Bass (Micropterus Dolomieu) Inhabiting New Jersey

Application of a stable Ag/TiO2 film in the simultaneous photodegradation of hormones

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Product

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Application of a stable Ag/TiO₂ film in the simultaneous photodegradation of hormones