Occurrence and Health Risk Assessment of Sulfonamide Antibiotics in Different Freshwater Fish in Northeast China

Abstract

This study aimed to investigate the levels of 12 sulfonamide antibiotics in freshwater fish species obtained from three cities in northeastern China (Harbin, Changchun, and Shenyang). The analysis was conducted using HPLC–MS/MS to accurately quantify the antibiotic concentrations in the fish samples. The results showed that the average levels of sulfonamide antibiotics in fish samples from Harbin, Changchun, and Shenyang were 1.83 ng/g ww, 0.98 ng/g ww, and 1.60 ng/g ww, respectively. Sulfamethoxazole displayed the highest levels and detection rates in all three cities, whereas sulphapyridine exhibited the lowest concentrations in all the fish samples. The levels of sulfonamide antibiotic residues in the different fish species varied widely among the cities, and the highest level of antibiotic residues was found in the muscle of carnivorous fish. The results from a health risk evaluation on the consumption of these fish indicated that the risk from long-term antibiotic exposure to local residents from the intake of the sampled fish was small and not sufficient to pose a significant health risk to consumers.

Preliminary investigation on the occurrence and health risk assessment of antibiotics in cultured tilapia retailed at a commercial outlet in Tema, Ghana

“…Additionally, a recent study conducted in Argentina on fish revealed that the estimated dietary exposure to multiantibiotic residues in commercial fish did not surpass the acceptable daily intake [ 16 ]. Unlike the present study, the acceptable daily intake of antibiotics for individuals consuming fish in Changchun and Shenyang was determined to be lower than the EDI value for Yellow Sea fish (0.065 μg/kg bw/day) [ 66 ]. The HQ values for antibiotics also varied between 2.30 × 10 −7 and 7.14 × 10 −4 .…”