Occurrence and removal of frequently prescribed pharmaceuticals and corresponding metabolites in wastewater of a sewage treatment plant

Gurke, Robert; Rößler, Martin; Marx, Christiane; Diamond, Sam; Schubert, Sara; Oertel, Reinhard; Fauler, Joachim

doi:10.1016/j.scitotenv.2015.06.067

Cited by 169 publications

(67 citation statements)

References 36 publications

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“…The presence of pharmaceuticals in municipal sewage during waste water treatment can lead to reduced overall performance due to the toxicity of drugs to the microbial community of the STP [21]. Due to insufficient removal potentially harmful active components can be often detected in various concentrations in STP effluents, greatly endangering the organisms in the recipient waters [21,22]. Chemical evaluation of complex waste water samples did not always correspond to ecotoxicity, so it is essential to complement chemical evaluation of municipal waste waters with ecotoxicological testing on different trophic levels [23].…”

Section: Discussionmentioning

confidence: 99%

Geno and cytotoxicologic assessment of wastewater effluents with mussel micronucleus assay and with flow cytometric sperm toxicity assay a comparison

Kakasi¹,

Horváth²,

Kováts³

et al. 2015

Third International Conference on Advances in Bio-Informatics and Environmental Engineering - ICABEE 2015

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Several pharmaceutical drugs have potential harmful effect on wildlife such as aquatic toxicity, genotoxicity, or endocrine disruption effect. Removal rates of pharmaceuticals from municipal sewage during waste water treatment is questionable, several studied drugs are insufficiently or not removed while passing through the sewage treatment plants (STP).The analytical monitoring of potentially harmful drugs and especially drug residues in influent and effluent of STP are rather costly and not always possible on a day to day basis. Toxicity bioassays, on the other hand, are relatively cost-effective short-term tests, estimating the aggregate genotoxicity of the samples on different taxonomic levels. In our study the cyto-and genotoxicity of the pre-treated potentially pharmaceutical containing influent and the effluent sample of a Hungarian STP were estimated with mussel (Unio pictorum) micronucleus (MN) assay and flow cytometric boar spermatozoa assay. The influent induced in the flow cytometric assay significant changes in mitochondrial transmembrane potential, oxidative DNA lesions and DNA fragmentation, but no significant genotoxic effect was detected by the MN assay. These results point to deficiencies of present wastewater treatment systems and remind us to choose carefully among available toxicity assays.

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Section: Discussionmentioning

confidence: 99%

Geno and cytotoxicologic assessment of wastewater effluents with mussel micronucleus assay and with flow cytometric sperm toxicity assay a comparison

Kakasi¹,

Horváth²,

Kováts³

et al. 2015

Third International Conference on Advances in Bio-Informatics and Environmental Engineering - ICABEE 2015

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“…The discharged pharmaceuticals and personal care products (PPCPs) or human or veterinary pharmaceuticals (or their metabolites) increased in the environment due to inadequate sewage treatment of wastewater in wastewater treatment plants (WWTPs) [150][151][152]. Owing to the negative effects of these contaminants on the aquatic environment and further affection on food safety, considerable interest has been driven at present on their detection and measurement.…”

Section: Pharmaceuticalsmentioning

confidence: 99%

Recent Progress on Luminescent Metal-Organic Framework-Involved Hybrid Materials for Rapid Determination of Contaminants in Environment and Food

et al. 2020

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The high speed of contaminants growth needs the burgeoning of new analytical techniques to keep up with the continuous demand for monitoring and legislation on food safety and environmental pollution control. Metal-organic frameworks (MOFs) are a kind of advanced crystal porous materials with controllable apertures, which are self-assembled by organic ligands and inorganic metal nodes. They have the merits of large specific surface areas, high porosity and the diversity of structures and functions. Latterly, the utilization of metal-organic frameworks has attracted much attention in environmental protection and the food industry. MOFs have exhibited great value as sensing materials for many targets. Among many sensing methods, fluorometric sensing is one of the widely studied methods in the detection of harmful substances in food and environmental samples. Fluorometric detection based on MOFs and its functional materials is currently one of the most key research subjects in the food and environmental fields. It has gradually become a hot research direction to construct the highly sensitive rapid sensors to detect harmful substances in the food matrix based on metal-organic frameworks. In this paper, we introduced the synthesis and detection application characteristics (absorption, fluorescence, etc.) of metal-organic frameworks. We summarized their applications in the MOFs-based fluorometric detection of harmful substances in food and water over the past few years. The harmful substances mainly include heavy metals, organic pollutants and other small molecules, etc. On this basis, the future development and possible application of the MOFs have prospected in this review paper.

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“…Therefore, the aim of multi-residue environmental analysis is to perform a targeted screening, which can be used to quantify as many pollutants as possible. Different methods have already been developed for the analysis of pharmaceuticals in environmental water or sludge samples [136,[161][162][163]. Because the concentration of some drugs is extremely low, very high sensitivities are pursued.…”

Section: Applicationsmentioning

confidence: 99%

Quantitative mass spectrometry methods for pharmaceutical analysis

Loos¹,

Schepdael²,

Cabooter³

2016

Phil. Trans. R. Soc. A.

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Quantitative pharmaceutical analysis is nowadays frequently executed using mass spectrometry. Electrospray ionization coupled to a (hybrid) triple quadrupole mass spectrometer is generally used in combination with solid-phase extraction and liquid chromatography. Furthermore, isotopically labelled standards are often used to correct for ion suppression. The challenges in producing sensitive but reliable quantitative data depend on the instrumentation, sample preparation and hyphenated techniques. In this contribution, different approaches to enhance the ionization efficiencies using modified source geometries and improved ion guidance are provided. Furthermore, possibilities to minimize, assess and correct for matrix interferences caused by co-eluting substances are described. With the focus on pharmaceuticals in the environment and bioanalysis, different separation techniques, trends in liquid chromatography and sample preparation methods to minimize matrix effects and increase sensitivity are discussed. Although highly sensitive methods are generally aimed for to provide automated multi-residue analysis, (less sensitive) miniaturized set-ups have a great potential due to their ability for in-field usage. This article is part of the themed issue ‘Quantitative mass spectrometry’.

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Occurrence and removal of frequently prescribed pharmaceuticals and corresponding metabolites in wastewater of a sewage treatment plant

Cited by 169 publications

References 36 publications

Geno and cytotoxicologic assessment of wastewater effluents with mussel micronucleus assay and with flow cytometric sperm toxicity assay a comparison

Geno and cytotoxicologic assessment of wastewater effluents with mussel micronucleus assay and with flow cytometric sperm toxicity assay a comparison

Recent Progress on Luminescent Metal-Organic Framework-Involved Hybrid Materials for Rapid Determination of Contaminants in Environment and Food

Quantitative mass spectrometry methods for pharmaceutical analysis

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