“…It is widely used in swine, cattle, poultry and fish husbandry as feed additives and veterinary drugs for prophylactic, and therapeutic purposes throughout the world, because of its low cost and effective antimicrobial (Lu et al, 2015). However, the widespread use of it has led to much environmental issues and human health problems (Marx et al, 2015;Li et al, 2015;Burkina et al, 2015;Auerbach et al, 2007;Luis Martinez, 2009), such as the presence of OTC residues in animal foods and environmental pollution (Kim et al, 2014;Fritz et al, 2007;Sun et al, 2014). Most of OTC leaves human and animal body unmetabolized via feces and urine Kemper, 2008).Therefore OTC is extensively distributed in soil, groundwater, surface water, sea water, and sediment worldwide (Shibata et al, 2014;Chen et al, 2015;Kuemmerer, 2009).…”