Occurrence and Significance of Riboflavin Deficiency in Preterm Infants

Lucas, Alan; Bates, Chris

doi:10.1159/000242747

Cited by 10 publications

(8 citation statements)

References 15 publications

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“…Their requirements may be greater than those of term infants because they have lower stores (because of the interruption of fetal accumulation), higher protein requirements, lower absorption, and a greater frequency of destruction by phototherapy for hyperbilirubinemia (American Academy of Pediatrics. Committee on Nutrition, 1998;Lucas & Bates, 1987).…”

Section: Review Of the Literaturementioning

confidence: 99%

Nutrient Requirements For Preterm Infant Formulas

Klein

2002

The Journal of Nutrition

328

231

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Achieving appropriate growth and nutrient accretion of preterm and low birth weight (LBW) infants is often difficult during hospitalization because of metabolic and gastrointestinal immaturity and other complicating medical conditions. Advances in the care of preterm-LBW infants, including improved nutrition, have reduced mortality rates for these infants from 9.6 to 6.2% from 1983 to 1997. The Food and Drug Administration (FDA) has responsibility for ensuring the safety and nutritional quality of infant formulas based on current scientific knowledge. Consequently, under FDA contract, an ad hoc Expert Panel was convened by the Life Sciences Research Office of the American Society for Nutritional Sciences to make recommendations for the nutrient content of formulas for preterm-LBW infants based on current scientific knowledge and expert opinion. Recommendations were developed from different criteria than that used for recommendations for term infant formula. To ensure nutrient adequacy, the Panel considered intrauterine accretion rate, organ development, factorial estimates of requirements, nutrient interactions and supplemental feeding studies. Consideration was also given to long-term developmental outcome. Some recommendations were based on current use in domestic preterm formula. Included were recommendations for nutrients not required in formula for term infants such as lactose and arginine. Recommendations, examples, and sample calculations were based on a 1000 g preterm infant consuming 120 kcal/kg and 150 mL/d of an 810 kcal/L formula. A summary of recommendations for energy and 45 nutrient components of enteral formulas for preterm-LBW infants are presented. Recommendations for five nutrient:nutrient ratios are also presented. In addition, critical areas for future research on the nutritional requirements specific for preterm-LBW infants are identified.

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Section: Review Of the Literaturementioning

confidence: 99%

Nutrient Requirements For Preterm Infant Formulas

Klein

2002

The Journal of Nutrition

328

231

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“…It is currently accepted that the mechanisms of transfer of riboflavin in utero favour the fetus [7,9]. In fact, our findings suggest riboflavin deficiency in the mothers, and indicate that the differences in maturity and of growth in the three groups did not affect riboflavin transport via the placenta.…”

Section: Discussionmentioning

confidence: 41%

“…1.20, according to COOPERMAN et al [6], 1.25 according to BAMJI [1] or 1.30 as accepted by LUCAS and BATES [9]. These data suggest mild deficiency of riboflavin in all groups.…”

Section: Discussionmentioning

confidence: 70%

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Vitamin dependent erythrocyte enzymes in newborns in relation to gestational age and birth weight

Ramos¹,

Barretto²,

Nonoyama³

1996

Jpme

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In order to search for any difference in riboflavin and pyridoxine nutrition between term appropriate for gestational age (TAGA), term small for gestational age (TSGA) and preterm appropriate for gestational age (PTAGA) newborns, cord blood from 23, 19 and 20 infants, respectively, were studied, and red cell glutathione reductase (riboflavin-dependent) and glutamic oxaloacetic transaminase (pyridoxine-dependent) activities were measured, as well as their respective activity coefficients (GRase AC and GOT AC). Red cell enzymes were assayed according to BEUTLER [4] in a Gilford recording spectrophotometer model 2451 at 37 degrees C. Values of 1.42, 1.39 and 1.32 of GRase AC and values of 1.17, 1.02 and 1.08 GOT AC, respectively were obtained. These data indicate that there is no significant difference between the three categories of newborns with regard to riboflavin and pyridoxine nutrition, and suggest that neither maturity nor adequacy of intrauterine growth were related to differences in the availability of these vitamins. All groups demonstrate a uniform mild deficiency of riboflavin and an adequate level of pyridoxine, probably the effect of maternal diet.

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“…A riboflavina é essencial para os processos de multiplicação celular, importante, portanto, nos processos de cicatrização e no crescimento do lactente. A causa mais frequente de deficiência de riboflavina no lactente é a fototerapia utilizada no tratamento da hiperbilirrubinemia (LUCAS;BATES, 1987 Fonte: Arruda (2009) A piridoxina (PN), piridoxal (PL) e piridoxamina (PM) são relativamente estáveis ao calor em meio ácido, mas termolábeis em meio alcalino (LEKLEM, 1991). As soluções ácidas de cloridrato de piridoxina podem ser aquecidas por 30 minutos a 120ºC sem apresentar decomposição (MERCK, 1989).…”

Section: Composição Do Arrozunclassified

Adubação e biofortificação: caraterização química e física do arroz (Oryza sativa L.)

Boliani¹

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Occurrence and Significance of Riboflavin Deficiency in Preterm Infants

Cited by 10 publications

References 15 publications

Nutrient Requirements For Preterm Infant Formulas

Nutrient Requirements For Preterm Infant Formulas

Vitamin dependent erythrocyte enzymes in newborns in relation to gestational age and birth weight

Adubação e biofortificação: caraterização química e física do arroz (Oryza sativa L.)

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